Dnhd1 dynein heavy chain domain 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dnhd1provided by MGI
Official Full Name: dynein heavy chain domain 1provided by MGI
Primary source: MGI:MGI:1924755
See related: Ensembl:ENSMUSG00000030882 AllianceGenome:MGI:1924755
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 8030491N06Rik
Summary: Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Involved in sperm flagellum assembly. Located in sperm flagellum. Is expressed in cartilage; central nervous system; genitourinary system; stomach; and trachea. Human ortholog(s) of this gene implicated in spermatogenic failure 65. Orthologous to human DNHD1 (dynein heavy chain domain 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 13.6), limb E14.5 (RPKM 1.2) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E3; 7 55.93 cM

Exon count:: 44

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (105299983..105371007)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (105650776..105721800)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Bi-allelic variants in DNHD1 cause flagellar axoneme defects and asthenoteratozoospermia in humans and mice.
Title: Bi-allelic variants in DNHD1 cause flagellar axoneme defects and asthenoteratozoospermia in humans and mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables dynein intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein intermediate chain binding	IEA Inferred from Electronic Annotation more info
enables dynein light intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein light intermediate chain binding	IEA Inferred from Electronic Annotation more info
enables minus-end-directed microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables minus-end-directed microtubule motor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in flagellated sperm motility	IBA Inferred from Biological aspect of Ancestor more info
involved_in flagellated sperm motility	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in flagellated sperm motility	ISO Inferred from Sequence Orthology more info
involved_in sperm flagellum assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sperm flagellum assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of dynein complex	IEA Inferred from Electronic Annotation more info
part_of inner dynein arm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in sperm flagellum	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm flagellum	IDA Inferred from Direct Assay more info	PubMed
located_in sperm flagellum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dynein heavy chain domain-containing protein 1

Names: coiled-coil domain-containing protein 35; dynein heavy chain domain 1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001370803.1 → NP_001357732.1 dynein heavy chain domain-containing protein 1

Status: VALIDATED

Source sequence(s)

AC121823, AC125227

UniProtKB/Swiss-Prot

D3Z2X2, F6YTV1, Q9CX41

UniProtKB/TrEMBL

A0A8Z1SZM7

Related

ENSMUSP00000121261.3, ENSMUST00000145988.9

Conserved Domains (8) summary

pfam12777
Location:3198 → 3468

MT; Microtubule-binding stalk of dynein motor

pfam03028
Location:4103 → 4222

Dynein_heavy; Dynein heavy chain and region D6 of dynein motor

pfam08393
Location:1021 → 1469

DHC_N2; Dynein heavy chain, N-terminal region 2

pfam12774
Location:1652 → 2005

AAA_6; Hydrolytic ATP binding site of dynein motor region D1

pfam12781
Location:3663 → 3801

AAA_9; ATP-binding dynein motor region D5

pfam17852
Location:2187 → 2347

Dynein_AAA_lid; Dynein heavy chain AAA lid domain

pfam18199
Location:4519 → 4744

Dynein_C; Dynein heavy chain C-terminal domain

cl38985
Location:2366 → 2533

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases