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Arfgap2 ARF GTPase activating protein 2 [ Mus musculus (house mouse) ]

Gene ID: 77038, updated on 27-Nov-2024

Summary

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Official Symbol
Arfgap2provided by MGI
Official Full Name
ARF GTPase activating protein 2provided by MGI
Primary source
MGI:MGI:1924288
See related
Ensembl:ENSMUSG00000027255 AllianceGenome:MGI:1924288
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zfp289; 2310032E02Rik
Summary
This gene encodes a zinc-finger-containing GTPase-activating protein for ADP ribosylation factor 1 (ARF1), a small GTPase that plays a role in coatomer-mediated vesicular trafficking. This gene product stimulates the hydrolysis of ARF1-bound GTP, which may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. It may regulate the retrograde transport from the Golgi complex to the endoplasmic reticulum. Expression of this gene has been shown to be controlled by inhibitor of DNA binding 1 (Id1). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene was identified on chromosome 6. [provided by RefSeq, Oct 2009]
Expression
Ubiquitous expression in thymus adult (RPKM 21.9), liver adult (RPKM 21.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Arfgap2 in Genome Data Viewer
Location:
2 E1; 2 50.62 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (91095460..91107716)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (91265115..91277371)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 31054 Neighboring gene STARR-positive B cell enhancer ABC_E3385 Neighboring gene protein kinase C and casein kinase substrate in neurons 3 Neighboring gene centriolar satellite-associated tubulin polyglutamylase complex regulator 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:91148974-91149175 Neighboring gene STARR-seq mESC enhancer starr_05115 Neighboring gene predicted gene 13787 Neighboring gene STARR-positive B cell enhancer ABC_E9518 Neighboring gene low density lipoprotein receptor-related protein 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular cloning and characterization of a zinc finger protein involved in Id-1-stimulated mammary epithelial cell growth. Singh J, et al. J Biol Chem, 2001 Apr 13. PMID 11278321
  2. Characterization of gene expression in mouse blastocyst using single-pass sequencing of 3995 clones. Sasaki N, et al. Genomics, 1998 Apr 15. PMID 9598303
  3. Lack of periostin leads to suppression of Notch1 signaling and calcific aortic valve disease. Tkatchenko TV, et al. Physiol Genomics, 2009 Nov 6. PMID 19723774, Free PMC Article
  4. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019
  5. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in COPI coating of Golgi vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ADP-ribosylation factor GTPase-activating protein 2
Names
ADP-ribosylation factor GTPase activating protein 2
ARF GAP 2
GTPase-activating protein ZNF289
zinc finger protein 289

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166024.1 → NP_001159496.1  ADP-ribosylation factor GTPase-activating protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001159496.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK009565, AK141749, AK169144, AL732478, BY648993
    Consensus CDS
    CCDS50639.1
    UniProtKB/Swiss-Prot
    Q99K28
    UniProtKB/TrEMBL
    Q3UR67
    Related
    ENSMUSP00000028691.7, ENSMUST00000028691.7
    Conserved Domains (2) summary
    PLN03114
    Location:3 → 484
    PLN03114; ADP-ribosylation factor GTPase-activating protein AGD10; Provisional
    pfam01412
    Location:11 → 117
    ArfGap; Putative GTPase activating protein for Arf

  2. NM_023854.2 → NP_076343.2  ADP-ribosylation factor GTPase-activating protein 2 isoform 2

    See identical proteins and their annotated locations for NP_076343.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AK141749, AK169144, AL732478, BY648993
    Consensus CDS
    CCDS16430.1
    UniProtKB/Swiss-Prot
    Q99K28, Q9D758, Q9JIH1
    Related
    ENSMUSP00000078920.7, ENSMUST00000080008.13
    Conserved Domains (2) summary
    PLN03114
    Location:3 → 470
    PLN03114; ADP-ribosylation factor GTPase-activating protein AGD10; Provisional
    pfam01412
    Location:11 → 117
    ArfGap; Putative GTPase activating protein for Arf

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    91095460..91107716
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99K28.1 GenPept UniProtKB/Swiss-Prot:Q99K28

Gene LinkOut

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