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Ralyl RALY RNA binding protein-like [ Mus musculus (house mouse) ]

Gene ID: 76897, updated on 4-Jan-2025

Summary

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Official Symbol
Ralylprovided by MGI
Official Full Name
RALY RNA binding protein-likeprovided by MGI
Primary source
MGI:MGI:1924147
See related
Ensembl:ENSMUSG00000039717 AllianceGenome:MGI:1924147
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0710005M24Rik
Summary
Predicted to enable RNA binding activity and identical protein binding activity. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in brain; cortical plate; spinal cord; and trigeminal ganglion. Orthologous to human RALYL (RALY RNA binding protein like). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in CNS E18 (RPKM 5.5), cerebellum adult (RPKM 4.8) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Ralyl in Genome Data Viewer
Location:
3 A1; 3 3.01 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (13535942..14247347)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (13471655..14182287)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_06983 Neighboring gene STARR-seq mESC enhancer starr_06984 Neighboring gene death effector domain-containing pseudogene Neighboring gene predicted gene, 54190 Neighboring gene STARR-seq mESC enhancer starr_06985 Neighboring gene STARR-seq mESC enhancer starr_06986 Neighboring gene RIKEN cDNA 4930539N22 gene Neighboring gene predicted gene 2464 Neighboring gene STARR-seq mESC enhancer starr_06988 Neighboring gene high mobility group protein B1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_06989 Neighboring gene solute carrier family 25, member 37 pseudogene Neighboring gene ganglioside-induced differentiation-associated-protein 2 pseudogene Neighboring gene predicted gene, 41998 Neighboring gene STARR-seq mESC enhancer starr_06990 Neighboring gene predicted gene, 18661 Neighboring gene STARR-seq mESC enhancer starr_06991 Neighboring gene STARR-seq mESC enhancer starr_06992 Neighboring gene STARR-seq mESC enhancer starr_06993 Neighboring gene transforming, acidic coiled-coil containing protein 3 pseudogene Neighboring gene predicted gene, 18659 Neighboring gene STARR-seq mESC enhancer starr_06995 Neighboring gene STARR-seq mESC enhancer starr_06996 Neighboring gene predicted gene, 23112 Neighboring gene solute carrier family 7 (cationic amino acid transporter, y+ system), member pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-β2. Wang X, et al. Nat Commun, 2021 Mar 9. PMID 33750796, Free PMC Article
  2. RALY RNA binding protein-like reduced expression is associated with poor prognosis in clear cell renal cell carcinoma. Cui ZW, et al. Asian Pac J Cancer Prev, 2012. PMID 22994768
  3. Systems genetic analysis of hippocampal neuroanatomy and spatial learning in mice. Delprato A, et al. Genes Brain Behav, 2015 Nov. PMID 26449520, Free PMC Article
  4. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
  5. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-beta2.
    Title: RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-β2.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RNA-binding Raly-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163328.1 → NP_001156800.1  RNA-binding Raly-like protein isoform a

    See identical proteins and their annotated locations for NP_001156800.1

    Status: VALIDATED

    Source sequence(s)
    AK032086, AK079659, CJ045018
    Consensus CDS
    CCDS84609.1
    UniProtKB/Swiss-Prot
    Q8BTF8, Q8BTF9, Q8BTG1
    Conserved Domains (2) summary
    cd12605
    Location:20 → 88
    RRM_RALYL; RNA recognition motif in vertebrate RNA-binding Raly-like protein (RALYL)
    pfam10779
    Location:201 → 246
    XhlA; Haemolysin XhlA

  2. NM_001163329.2 → NP_001156801.1  RNA-binding Raly-like protein isoform b

    See identical proteins and their annotated locations for NP_001156801.1

    Status: VALIDATED

    Source sequence(s)
    AC192090, AK032086, AK038465, BY252332
    Consensus CDS
    CCDS50863.1
    UniProtKB/Swiss-Prot
    Q8BTF8
    Related
    ENSMUSP00000104009.3, ENSMUST00000108372.4
    Conserved Domains (1) summary
    pfam10779
    Location:128 → 173
    XhlA; Haemolysin XhlA

  3. NM_001163330.2 → NP_001156802.1  RNA-binding Raly-like protein isoform c

    Status: VALIDATED

    Source sequence(s)
    AC192090, AK032086, AK038465, BY252332
    Consensus CDS
    CCDS50864.1
    UniProtKB/TrEMBL
    A0A0A6YXQ8, E9Q5X7
    Related
    ENSMUSP00000142094.2, ENSMUST00000192209.6

  4. NM_001357033.1 → NP_001343962.1  RNA-binding Raly-like protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC121588, AC161601, AK079659
    Consensus CDS
    CCDS84609.1
    UniProtKB/Swiss-Prot
    Q8BTF8, Q8BTF9, Q8BTG1
    Related
    ENSMUSP00000148795.2, ENSMUST00000193117.3
    Conserved Domains (2) summary
    cd12605
    Location:20 → 88
    RRM_RALYL; RNA recognition motif in vertebrate RNA-binding Raly-like protein (RALYL)
    pfam10779
    Location:201 → 246
    XhlA; Haemolysin XhlA

  5. NM_001357034.1 → NP_001343963.1  RNA-binding Raly-like protein isoform d

    Status: VALIDATED

    Source sequence(s)
    AC121588, AC147237, AC161601, AC192090
    Conserved Domains (1) summary
    cl17169
    Location:29 → 111
    RRM_SF; RNA recognition motif (RRM) superfamily

  6. NM_001357035.1 → NP_001343964.1  RNA-binding Raly-like protein isoform e

    Status: VALIDATED

    Source sequence(s)
    AC121588, AC147237, AC161601, AC192090
    Conserved Domains (1) summary
    cl17169
    Location:15 → 97
    RRM_SF; RNA recognition motif (RRM) superfamily

  7. NM_001357036.1 → NP_001343965.1  RNA-binding Raly-like protein isoform f

    Status: VALIDATED

    Source sequence(s)
    AC121588, AC147237, AC161601, AC192090
    Conserved Domains (2) summary
    pfam10779
    Location:215 → 260
    XhlA; Haemolysin XhlA
    cl17169
    Location:29 → 111
    RRM_SF; RNA recognition motif (RRM) superfamily

  8. NM_178631.4 → NP_848746.1  RNA-binding Raly-like protein isoform a

    See identical proteins and their annotated locations for NP_848746.1

    Status: VALIDATED

    Source sequence(s)
    AK032086, AK079659, CJ045018
    Consensus CDS
    CCDS84609.1
    UniProtKB/Swiss-Prot
    Q8BTF8, Q8BTF9, Q8BTG1
    Conserved Domains (2) summary
    cd12605
    Location:20 → 88
    RRM_RALYL; RNA recognition motif in vertebrate RNA-binding Raly-like protein (RALYL)
    pfam10779
    Location:201 → 246
    XhlA; Haemolysin XhlA

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    13535942..14247347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163401.1 → XP_036019294.1  RNA-binding Raly-like protein isoform X9

    Conserved Domains (1) summary
    cl17169
    Location:15 → 97
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. XM_036163397.1 → XP_036019290.1  RNA-binding Raly-like protein isoform X6

    Conserved Domains (1) summary
    cl17169
    Location:15 → 97
    RRM_SF; RNA recognition motif (RRM) superfamily

  3. XM_036163396.1 → XP_036019289.1  RNA-binding Raly-like protein isoform X6

    Conserved Domains (1) summary
    cl17169
    Location:15 → 97
    RRM_SF; RNA recognition motif (RRM) superfamily

  4. XM_036163400.1 → XP_036019293.1  RNA-binding Raly-like protein isoform X9

    Conserved Domains (1) summary
    cl17169
    Location:15 → 97
    RRM_SF; RNA recognition motif (RRM) superfamily

  5. XM_036163395.1 → XP_036019288.1  RNA-binding Raly-like protein isoform X4

    Conserved Domains (2) summary
    pfam10779
    Location:190 → 235
    XhlA; Haemolysin XhlA
    cl17169
    Location:15 → 97
    RRM_SF; RNA recognition motif (RRM) superfamily

  6. XM_036163402.1 → XP_036019295.1  RNA-binding Raly-like protein isoform X10

    Conserved Domains (1) summary
    cl17169
    Location:15 → 97
    RRM_SF; RNA recognition motif (RRM) superfamily

  7. XM_036163394.1 → XP_036019287.1  RNA-binding Raly-like protein isoform X1

    Conserved Domains (2) summary
    pfam10779
    Location:215 → 260
    XhlA; Haemolysin XhlA
    cl17169
    Location:29 → 111
    RRM_SF; RNA recognition motif (RRM) superfamily

  8. XM_036163398.1 → XP_036019291.1  RNA-binding Raly-like protein isoform X7

    Conserved Domains (1) summary
    cl17169
    Location:29 → 111
    RRM_SF; RNA recognition motif (RRM) superfamily

  9. XM_006530102.3 → XP_006530165.1  RNA-binding Raly-like protein isoform X5

    Conserved Domains (1) summary
    cd12605
    Location:34 → 102
    RRM_RALYL; RNA recognition motif in vertebrate RNA-binding Raly-like protein (RALYL)

  10. XM_006530101.3 → XP_006530164.1  RNA-binding Raly-like protein isoform X2

    Conserved Domains (2) summary
    cd12605
    Location:34 → 102
    RRM_RALYL; RNA recognition motif in vertebrate RNA-binding Raly-like protein (RALYL)
    pfam10779
    Location:204 → 249
    XhlA; Haemolysin XhlA

  11. XM_036163399.1 → XP_036019292.1  RNA-binding Raly-like protein isoform X8

    Conserved Domains (1) summary
    cl17169
    Location:29 → 111
    RRM_SF; RNA recognition motif (RRM) superfamily

  12. XM_011248150.3 → XP_011246452.1  RNA-binding Raly-like protein isoform X3

    See identical proteins and their annotated locations for XP_011246452.1

    UniProtKB/Swiss-Prot
    Q8BTF8, Q8BTF9, Q8BTG1
    Conserved Domains (2) summary
    cd12605
    Location:20 → 88
    RRM_RALYL; RNA recognition motif in vertebrate RNA-binding Raly-like protein (RALYL)
    pfam10779
    Location:201 → 246
    XhlA; Haemolysin XhlA

  13. XM_030252881.2 → XP_030108741.1  RNA-binding Raly-like protein isoform X13

    UniProtKB/TrEMBL
    E9Q5X7

  14. XM_030252880.2 → XP_030108740.1  RNA-binding Raly-like protein isoform X12

  15. XM_030252879.2 → XP_030108739.1  RNA-binding Raly-like protein isoform X11

    Conserved Domains (1) summary
    pfam10779
    Location:117 → 162
    XhlA; Haemolysin XhlA
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BTF8.1 GenPept UniProtKB/Swiss-Prot:Q8BTF8

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