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myh7l myosin heavy chain 7-like [ Danio rerio (zebrafish) ]

Gene ID: 768300, updated on 9-Dec-2024

Summary

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Official Symbol
myh7lprovided by ZNC
Official Full Name
myosin heavy chain 7-likeprovided by ZNC
Primary source
ZFIN:ZDB-GENE-061027-393
See related
Ensembl:ENSDARG00000079782 AllianceGenome:ZFIN:ZDB-GENE-061027-393
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
Myh1; vmhcl; zgc:113832; zgc:152732
Summary
Predicted to enable actin filament binding activity and microfilament motor activity. Acts upstream of or within cardiac ventricle development and regulation of cardiac muscle hypertrophy. Predicted to be located in sarcomere. Predicted to be part of myosin II complex. Predicted to be active in cytoplasm and myosin filament. Is expressed in adaxial cell; cardiovascular system; and myotome. Human ortholog(s) of this gene implicated in cardiomyopathy (multiple); congenital heart disease (multiple); distal myopathy 1; and hyaline body myopathy (multiple). Orthologous to human MYH7 (myosin heavy chain 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See myh7l in Genome Data Viewer
Location:
chromosome: 2
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (24274324..24289641, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (24618673..24633990, complement)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene microtubule associated protein 4 like Neighboring gene microRNA 736 Neighboring gene myosin heavy chain 7 Neighboring gene fat storage inducing transmembrane protein 1, like Neighboring gene tRNA selenocysteine 1 associated protein 1b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A Novel Missense Variant in Actin Binding Domain of MYH7 Is Associated With Left Ventricular Noncompaction. Hesaraki M, et al. Front Cardiovasc Med, 2022. PMID 35463789, Free PMC Article
  2. Obscurin Maintains Myofiber Identity in Extraocular Muscles. Kahsay A, et al. Invest Ophthalmol Vis Sci, 2024 Feb 1. PMID 38334702, Free PMC Article
  3. Fam40b is required for lineage commitment of murine embryonic stem cells. Wagh V, et al. Cell Death Dis, 2014 Jul 10. PMID 25010986, Free PMC Article
  4. Phenotyping an adult zebrafish lamp2 cardiomyopathy model identifies mTOR inhibition as a candidate therapy. Dvornikov AV, et al. J Mol Cell Cardiol, 2019 Aug. PMID 31228518, Free PMC Article
  5. A Heterozygous Mutation in Cardiac Troponin T Promotes Ca(2+) Dysregulation and Adult Cardiomyopathy in Zebrafish. Kamel SM, et al. J Cardiovasc Dev Dis, 2021 Apr 20. PMID 33924051, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC113832, MGC152732

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cardiac ventricle development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of cardiac muscle hypertrophy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  
located_in sarcomere IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
myosin heavy chain 7-like
Names
ventricular myosin heavy chain-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077464.2 → NP_001070932.2  myosin heavy chain 7-like

    Status: PROVISIONAL

    Source sequence(s)
    BC096949, BC150349, EB884317, EB887670, EB889739, EB890977, EB896917
    UniProtKB/TrEMBL
    A0A8M1NBP6
    Related
    ENSDARP00000110789.2, ENSDART00000128784.4
    Conserved Domains (9) summary
    cd01377
    Location:99 → 766
    MYSc_class_II; class II myosins, motor domain
    pfam00063
    Location:87 → 766
    Myosin_head; Myosin head (motor domain)
    pfam01576
    Location:846 → 1923
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:35 → 72
    Myosin_N; Myosin N-terminal SH3-like domain
    cl00459
    Location:1295 → 1407
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    cl00817
    Location:1132 → 1293
    MM_CoA_mutase; Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of ...
    cl19764
    Location:1372 → 1505
    COG6; Conserved oligomeric complex COG6
    cl21478
    Location:1500 → 1608
    ATP-synt_B; ATP synthase B/B' CF(0)
    cl23720
    Location:961 → 1094
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    24274324..24289641 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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