ube2t ubiquitin-conjugating enzyme E2T (putative) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ube2tprovided by ZNC
Official Full Name: ubiquitin-conjugating enzyme E2T (putative)provided by ZNC
Primary source: ZFIN:ZDB-GENE-061013-547
See related: Ensembl:ENSDARG00000063285 AllianceGenome:ZFIN:ZDB-GENE-061013-547
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fanct; wu:fj86h11; zgc:153687
Summary: Predicted to enable chromatin binding activity and ubiquitin conjugating enzyme activity. Predicted to be involved in DNA repair and protein ubiquitination. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group T. Orthologous to human UBE2T (ubiquitin conjugating enzyme E2 T). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 23

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (5104743..5108059)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (5185318..5188634, complement)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin conjugating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin conjugating enzyme activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein autoubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein monoubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ubiquitin-conjugating enzyme E2 T

Names: E2 ubiquitin-conjugating enzyme T; ubiquitin carrier protein T; ubiquitin-protein ligase T

NP_001070763.1

EC 2.3.2.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077295.2 → NP_001070763.1 ubiquitin-conjugating enzyme E2 T

See identical proteins and their annotated locations for NP_001070763.1

Status: PROVISIONAL

Source sequence(s)

BC124718

UniProtKB/Swiss-Prot

F1R970, Q08BH7

Related

ENSDARP00000107045.2, ENSDART00000123191.3

Conserved Domains (1) summary

cd00195
Location:4 → 147

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...