dclre1b DNA cross-link repair 1B [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dclre1bprovided by ZNC
Official Full Name: DNA cross-link repair 1Bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-061013-328
See related: Ensembl:ENSDARG00000068833 AllianceGenome:ZFIN:ZDB-GENE-061013-328
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:6894074; zgc:154089
Summary: Predicted to enable 5'-3' DNA exonuclease activity; beta-lactamase activity; and damaged DNA binding activity. Predicted to be involved in DNA metabolic process. Predicted to act upstream of or within DNA repair. Predicted to be located in centrosome and chromosome, telomeric region. Human ortholog(s) of this gene implicated in dyskeratosis congenita. Orthologous to human DCLRE1B (DNA cross-link repair 1B). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (24108459..24113492, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (24087220..24092253, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 5'-3' DNA exonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables 5'-3' exonuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables beta-lactamase activity	IEA Inferred from Electronic Annotation more info
enables beta-lactamase activity	ISS Inferred from Sequence or Structural Similarity more info
enables damaged DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables exonuclease activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on ester bonds	IEA Inferred from Electronic Annotation more info
enables nuclease activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via nonhomologous end joining	IBA Inferred from Biological aspect of Ancestor more info
involved_in interstrand cross-link repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in protection from non-homologous end joining at telomere	ISS Inferred from Sequence or Structural Similarity more info
involved_in telomere maintenance	IBA Inferred from Biological aspect of Ancestor more info
involved_in telomere maintenance	ISS Inferred from Sequence or Structural Similarity more info
involved_in telomeric 3' overhang formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in telomeric loop formation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in chromosome, telomeric region	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 5' exonuclease Apollo

Names: DNA cross-link repair 1B protein; SNM1 homolog B; beta-lactamase MBLAC2

NP_001070751.1

EC 3.5.2.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077283.1 → NP_001070751.1 5' exonuclease Apollo

See identical proteins and their annotated locations for NP_001070751.1

Status: PROVISIONAL

Source sequence(s)

BC124809

UniProtKB/Swiss-Prot

B0V2S2, Q08BA3

Related

ENSDARP00000090466.3, ENSDART00000099692.4

Conserved Domains (2) summary

pfam07522
Location:217 → 302

DRMBL; DNA repair metallo-beta-lactamase

cd16273
Location:4 → 152

SNM1A-1C-like_MBL-fold; SNM1A , artemis/SNM1C, yeast Pso2p, and related proteins; MBL-fold metallo-hydrolase domain