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Zfp998 zinc finger protein 998 [ Mus musculus (house mouse) ]

Gene ID: 76803, updated on 27-Nov-2024

Summary

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Official Symbol
Zfp998provided by MGI
Official Full Name
zinc finger protein 998provided by MGI
Primary source
MGI:MGI:1924053
See related
Ensembl:ENSMUSG00000074832 AllianceGenome:MGI:1924053
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Snerv1; Ayu21-35; 2410141K09Rik; 4930482J15Rik; Gt(pU21)35Imeg
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Orthologous to several human genes including ZNF117 (zinc finger protein 117); ZNF490 (zinc finger protein 490); and ZNF708 (zinc finger protein 708). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
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Genomic context

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See Zfp998 in Genome Data Viewer
Location:
13 B3; 13 34.52 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (66566173..66589190, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (66418114..66441118, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26715 Neighboring gene predicted gene, 33043 Neighboring gene STARR-seq mESC enhancer starr_34869 Neighboring gene upstream binding transcription factor, RNA polymerase I pseudogene Neighboring gene STARR-seq mESC enhancer starr_34870 Neighboring gene STARR-seq mESC enhancer starr_34871 Neighboring gene STARR-seq mESC enhancer starr_34873 Neighboring gene vomeronasal 2, receptor, pseudogene 105 Neighboring gene predicted gene, 46428

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Gv1, a Zinc Finger Gene Controlling Endogenous MLV Expression. Young GR, et al. Mol Biol Evol, 2021 May 19. PMID 33560369, Free PMC Article
  2. The Lupus Susceptibility Locus Sgp3 Encodes the Suppressor of Endogenous Retrovirus Expression SNERV. Treger RS, et al. Immunity, 2019 Feb 19. PMID 30709743, Free PMC Article
  3. Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes. Ostapcuk V, et al. Nature, 2018 May. PMID 29795351
  4. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
  5. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1)  1 citation
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein-like
Names
Gt(Ayu21)35Imeg

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290196.2 → NP_001277125.1  zinc finger protein-like isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer variant and encodes the longer isoform (a).
    Source sequence(s)
    AC164297, AK010804
    Consensus CDS
    CCDS84031.1
    UniProtKB/TrEMBL
    K7N769
    Related
    ENSMUSP00000134352.3, ENSMUST00000172579.4
    Conserved Domains (5) summary
    smart00349
    Location:4 → 46
    KRAB; krueppel associated box
    COG5048
    Location:72 → 452
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:77 → 97
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 43
    KRAB; KRAB box
    pfam13465
    Location:117 → 142
    zf-H2C2_2; Zinc-finger double domain

  2. NM_183119.3 → NP_898942.1  zinc finger protein-like isoform b

    See identical proteins and their annotated locations for NP_898942.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains alternate 3' exon structure, and it thus differs in its 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC164297, AK010804
    Consensus CDS
    CCDS70474.1
    UniProtKB/TrEMBL
    Q8C1L2
    Related
    ENSMUSP00000134048.2, ENSMUST00000173583.8
    Conserved Domains (2) summary
    smart00349
    Location:4 → 46
    KRAB; krueppel associated box
    pfam01352
    Location:4 → 43
    KRAB; KRAB box

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    66566173..66589190 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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