f13a1a.1 coagulation factor XIII, A1 polypeptide a, tandem duplicate 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: f13a1a.1provided by ZNC
Official Full Name: coagulation factor XIII, A1 polypeptide a, tandem duplicate 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-060929-1250
See related: Ensembl:ENSDARG00000045453 AllianceGenome:ZFIN:ZDB-GENE-060929-1250
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:152982
Summary: Predicted to enable protein-glutamine gamma-glutamyltransferase activity. Predicted to be involved in blood coagulation, fibrin clot formation. Predicted to act upstream of or within peptide cross-linking. Human ortholog(s) of this gene implicated in artery disease (multiple); factor XIII deficiency; priapism; and thrombophilia (multiple). Orthologous to human F13A1 (coagulation factor XIII A chain). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 24

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (2495197..2515620)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (2499153..2519579)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein-glutamine gamma-glutamyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-glutamine gamma-glutamyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in blood coagulation, fibrin clot formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within peptide cross-linking	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: coagulation factor XIII, A1 polypeptide a, tandem duplicate 1

Names: FXIIIa-42; f13a1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001076711.2 → NP_001070179.2 coagulation factor XIII, A1 polypeptide a, tandem duplicate 1

Status: VALIDATED

Source sequence(s)

CR376727, CR392025

UniProtKB/TrEMBL

A0A8M3AP15, F1QC84

Related

ENSDARP00000120334.1, ENSDART00000146887.2

Conserved Domains (3) summary

smart00460
Location:310 → 401

TGc; Transglutaminase/protease-like homologues

pfam00868
Location:49 → 159

Transglut_N; Transglutaminase family

pfam00927
Location:629 → 726

Transglut_C; Transglutaminase family, C-terminal ig like domain