Ctrc chymotrypsin C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ctrcprovided by MGI
Official Full Name: chymotrypsin Cprovided by MGI
Primary source: MGI:MGI:1923951
See related: Ensembl:ENSMUSG00000062478 AllianceGenome:MGI:1923951
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: caldecrin; 1810044E12Rik
Summary: Enables serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within intracellular calcium ion homeostasis. Orthologous to human CTRC (chymotrypsin C). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Expression: Biased expression in small intestine adult (RPKM 1775.4), spleen adult (RPKM 409.6) and 1 other tissue See more
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Genomic context

Location:: 4 D3; 4 74.75 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (141565550..141573598, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (141838239..141846287, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Caldecrin inhibits lipopolysaccharide-induced pro-inflammatory cytokines and M1 macrophage polarization through the immunoreceptor triggering receptor expressed in myeloid cells-2.
Title: Caldecrin inhibits lipopolysaccharide-induced pro-inflammatory cytokines and M1 macrophage polarization through the immunoreceptor triggering receptor expressed in myeloid cells-2.
Natural single-nucleotide deletion in chymotrypsinogen C gene increases severity of secretagogue-induced pancreatitis in C57BL/6 mice.
Title: Natural single-nucleotide deletion in chymotrypsinogen C gene increases severity of secretagogue-induced pancreatitis in C57BL/6 mice.
autoactivation of mouse trypsinogens is under the control of mouse Ctrc.
Title: Autoactivation of mouse trypsinogens is regulated by chymotrypsin C via cleavage of the autolysis loop.
Data show that ectopic expression of the caldecrin gene in the muscle of dy/dy mice reduced the level of blood urea nitrogen and improved the dystrophic progression similarly to that of caldecrin-injected mice.
Title: Serum calcium-decreasing factor, caldecrin, ameliorates muscular dystrophy in dy/dy mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1) 1 citation
Targeted (3)

General gene information

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Markers

D4Mit65 (e-PCR), detects polymorphism
- UniSTS:130182

NoName (e-PCR)
- UniSTS:488949

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables peptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: chymotrypsin-C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033875.2 → NP_001029047.1 chymotrypsin-C precursor

See identical proteins and their annotated locations for NP_001029047.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the functional non-reference strain allele and encodes the full-length protein.

Source sequence(s)

BC103715, BC115516

UniProtKB/Swiss-Prot

Q3SYP2

Conserved Domains (2) summary

smart00020
Location:29 → 262

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:30 → 265

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RNA

NR_160701.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (1, non-coding) includes a premature stop codon and represents the non-functional allele, as in the C57BL/6 reference genome.

Source sequence(s)

AL645731, AL928577

Related

ENSMUST00000153282.2