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Pcnp PEST proteolytic signal containing nuclear protein [ Mus musculus (house mouse) ]

Gene ID: 76302, updated on 27-Nov-2024

Summary

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Official Symbol
Pcnpprovided by MGI
Official Full Name
PEST proteolytic signal containing nuclear proteinprovided by MGI
Primary source
MGI:MGI:1923552
See related
Ensembl:ENSMUSG00000071533 AllianceGenome:MGI:1923552
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110018D06Rik
Summary
Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to be located in nuclear body. Predicted to be active in nucleus. Is expressed in embryo. Orthologous to human PCNP (PEST proteolytic signal containing nuclear protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E11.5 (RPKM 33.7), CNS E14 (RPKM 24.4) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Pcnp in Genome Data Viewer
Location:
16 C1.1; 16 33.77 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (55835870..55851590, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (56015507..56029727, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2466 Neighboring gene STARR-positive B cell enhancer ABC_E4180 Neighboring gene zinc finger and BTB domain containing 11, opposite strand 1 Neighboring gene ribosomal protein L24 Neighboring gene STARR-seq mESC enhancer starr_41052 Neighboring gene zinc finger and BTB domain containing 11 Neighboring gene STARR-positive B cell enhancer ABC_E10912 Neighboring gene STARR-positive B cell enhancer ABC_E5549 Neighboring gene tRNA methyltransferase 10C, mitochondrial RNase P subunit Neighboring gene predicted gene, 22422 Neighboring gene predicted gene, 57818 Neighboring gene SUMO1/sentrin specific peptidase 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Caspase-3 regulates catalytic activity and scaffolding functions of the protein tyrosine phosphatase PEST, a novel modulator of the apoptotic response. Hallé M, et al. Mol Cell Biol, 2007 Feb. PMID 17130234, Free PMC Article
  2. Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. Tamplin OJ, et al. BMC Genomics, 2008 Oct 30. PMID 18973680, Free PMC Article
  3. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
  4. Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells. Zhang S, et al. Sci Data, 2018 Nov 20. PMID 30457570, Free PMC Article
  5. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
PEST proteolytic signal-containing nuclear protein
Names
PEST-containing nuclear protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024622.2 → NP_001019793.1  PEST proteolytic signal-containing nuclear protein isoform 4

    See identical proteins and their annotated locations for NP_001019793.1

    Status: VALIDATED

    Source sequence(s)
    BC061235, BC106192, BY287179
    Consensus CDS
    CCDS37357.1
    UniProtKB/Swiss-Prot
    Q6P8I4
    UniProtKB/TrEMBL
    Q3UCC5
    Related
    ENSMUSP00000110087.3, ENSMUST00000114444.9
    Conserved Domains (1) summary
    pfam15473
    Location:23 → 171
    PCNP; PEST, proteolytic signal-containing nuclear protein family

  2. NM_001356448.1 → NP_001343377.1  PEST proteolytic signal-containing nuclear protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC171202
    Conserved Domains (1) summary
    pfam15473
    Location:20 → 151
    PCNP; PEST, proteolytic signal-containing nuclear protein family

  3. NM_001356449.1 → NP_001343378.1  PEST proteolytic signal-containing nuclear protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC171202
    Consensus CDS
    CCDS88942.1
    UniProtKB/TrEMBL
    F8WI88
    Related
    ENSMUSP00000093720.4, ENSMUST00000096021.10
    Conserved Domains (1) summary
    pfam15473
    Location:34 → 182
    PCNP; PEST, proteolytic signal-containing nuclear protein family

  4. NM_001356450.1 → NP_001343379.1  PEST proteolytic signal-containing nuclear protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC171202
    Related
    ENSMUSP00000112565.2, ENSMUST00000119981.8
    Conserved Domains (1) summary
    pfam15473
    Location:1 → 103
    PCNP; PEST, proteolytic signal-containing nuclear protein family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    55835870..55851590 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522697.5 → XP_006522760.1  PEST proteolytic signal-containing nuclear protein isoform X2

    See identical proteins and their annotated locations for XP_006522760.1

    Conserved Domains (1) summary
    pfam15473
    Location:23 → 170
    PCNP; PEST, proteolytic signal-containing nuclear protein family

  2. XM_036160175.1 → XP_036016068.1  PEST proteolytic signal-containing nuclear protein isoform X1

    Conserved Domains (1) summary
    pfam15473
    Location:75 → 212
    PCNP; PEST, proteolytic signal-containing nuclear protein family

  3. XM_030249326.1 → XP_030105186.1  PEST proteolytic signal-containing nuclear protein isoform X3

    Conserved Domains (1) summary
    pfam15473
    Location:20 → 150
    PCNP; PEST, proteolytic signal-containing nuclear protein family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P8I4.1 GenPept UniProtKB/Swiss-Prot:Q6P8I4

Gene LinkOut

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