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ZSCAN20 zinc finger and SCAN domain containing 20 [ Homo sapiens (human) ]

Gene ID: 7579, updated on 27-Nov-2024

Summary

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Official Symbol
ZSCAN20provided by HGNC
Official Full Name
zinc finger and SCAN domain containing 20provided by HGNC
Primary source
HGNC:HGNC:13093
See related
Ensembl:ENSG00000121903 MIM:611315; AllianceGenome:HGNC:13093
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KOX29; ZNF31; ZFP-31; ZNF360
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

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See ZSCAN20 in Genome Data Viewer
Location:
1p35.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (33472645..33501643)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (33334198..33363244)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (33938246..33967243)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene NANOG hESC enhancer GRCh37_chr1:33821846-33822366 Neighboring gene VISTA enhancer hs1388 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33832336-33833239 Neighboring gene PHC2 antisense RNA 1 Neighboring gene polyhomeotic homolog 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 624 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33920469-33920968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 708 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 709 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 625 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33933768-33934294 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33934295-33934819 Neighboring gene Sharpr-MPRA regulatory region 11456 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:33975098-33976006 Neighboring gene proteasome 20S subunit alpha 3 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33985189-33985725 Neighboring gene toll like receptor 12, pseudogene Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_7293 Neighboring gene CUB and Sushi multiple domains 2 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:34070585-34071784 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:34073062-34073562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:34073563-34074063 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:34099135-34099641 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr1:34100609-34101540 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr1:34101541-34102471 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:34102434-34102604 Neighboring gene uncharacterized LOC124903976

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy. Jordanova A, et al. Nat Genet, 2006 Feb. PMID 16429158
  2. PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation. Choi SW, et al. Mol Cell, 2018 Jun 7. PMID 29883609
  3. Multiple genes encoding zinc finger domains are expressed in human T cells. Thiesen HJ. New Biol, 1990 Apr. PMID 2288909
  4. Identification of proteins that interact with alpha A-crystallin using a human proteome microarray. Fan Q, et al. Mol Vis, 2014. PMID 24453475, Free PMC Article
  5. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. Chen Y, et al. Mol Cell Proteomics, 2013 Oct. PMID 23824909, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger and SCAN domain-containing protein 20
Names
zinc finger protein 31
zinc finger protein 360
zinc finger protein KOX29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001377376.1 → NP_001364305.1  zinc finger and SCAN domain-containing protein 20 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC115285, AL138837
    Consensus CDS
    CCDS41300.1
    UniProtKB/Swiss-Prot
    A8K2D0, B1ALI4, B1ALI5, B1ALI6, P17040, Q6ZN23, Q96FA9, Q96H84
    Related
    ENSP00000507139.1, ENST00000684572.1
    Conserved Domains (4) summary
    COG5048
    Location:699 → 1029
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:740 → 760
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:47 → 132
    SCAN; SCAN domain
    pfam13837
    Location:323 → 404
    Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain

  2. NM_001377377.1 → NP_001364306.1  zinc finger and SCAN domain-containing protein 20 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC115285, AL138837
    Conserved Domains (4) summary
    COG5048
    Location:698 → 1028
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:739 → 759
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:47 → 132
    SCAN; SCAN domain
    pfam13837
    Location:323 → 404
    Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain

  3. NM_001377378.1 → NP_001364307.1  zinc finger and SCAN domain-containing protein 20 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC115285, AL138837
    Conserved Domains (4) summary
    COG5048
    Location:645 → 975
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:686 → 706
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:47 → 132
    SCAN; SCAN domain
    pfam13837
    Location:269 → 350
    Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain

  4. NM_001377379.1 → NP_001364308.1  zinc finger and SCAN domain-containing protein 20 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC115285, AL138837
    Conserved Domains (3) summary
    COG5048
    Location:381 → 711
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:422 → 442
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13837
    Location:5 → 86
    Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain

  5. NM_145238.6 → NP_660281.3  zinc finger and SCAN domain-containing protein 20 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC115285, AL138837
    Consensus CDS
    CCDS41300.1
    UniProtKB/Swiss-Prot
    A8K2D0, B1ALI4, B1ALI5, B1ALI6, P17040, Q6ZN23, Q96FA9, Q96H84
    Related
    ENSP00000355053.3, ENST00000361328.7
    Conserved Domains (4) summary
    COG5048
    Location:699 → 1029
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:740 → 760
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:47 → 132
    SCAN; SCAN domain
    pfam13837
    Location:323 → 404
    Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    33472645..33501643
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047429973.1 → XP_047285929.1  zinc finger and SCAN domain-containing protein 20 isoform X4

  2. XM_047429974.1 → XP_047285930.1  zinc finger and SCAN domain-containing protein 20 isoform X5

  3. XM_017002238.2 → XP_016857727.1  zinc finger and SCAN domain-containing protein 20 isoform X2

    UniProtKB/Swiss-Prot
    P17040
    Conserved Domains (4) summary
    COG5048
    Location:698 → 1028
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:739 → 759
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:47 → 132
    SCAN; SCAN domain
    pfam13837
    Location:323 → 404
    Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain

  4. XM_047429971.1 → XP_047285927.1  zinc finger and SCAN domain-containing protein 20 isoform X3

  5. XM_017002237.2 → XP_016857726.1  zinc finger and SCAN domain-containing protein 20 isoform X1

    UniProtKB/Swiss-Prot
    A8K2D0, B1ALI4, B1ALI5, B1ALI6, P17040, Q6ZN23, Q96FA9, Q96H84
    Conserved Domains (4) summary
    COG5048
    Location:699 → 1029
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:740 → 760
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:47 → 132
    SCAN; SCAN domain
    pfam13837
    Location:323 → 404
    Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain

  6. XM_047429970.1 → XP_047285926.1  zinc finger and SCAN domain-containing protein 20 isoform X2

  7. XM_047429972.1 → XP_047285928.1  zinc finger and SCAN domain-containing protein 20 isoform X3

  8. XM_017002241.2 → XP_016857730.1  zinc finger and SCAN domain-containing protein 20 isoform X6

    Conserved Domains (3) summary
    COG5048
    Location:381 → 711
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:422 → 442
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13837
    Location:5 → 86
    Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain

  9. XM_047429975.1 → XP_047285931.1  zinc finger and SCAN domain-containing protein 20 isoform X6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    33334198..33363244
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054338614.1 → XP_054194589.1  zinc finger and SCAN domain-containing protein 20 isoform X1

  2. XM_054338616.1 → XP_054194591.1  zinc finger and SCAN domain-containing protein 20 isoform X2

  3. XM_054338618.1 → XP_054194593.1  zinc finger and SCAN domain-containing protein 20 isoform X3

  4. XM_054338619.1 → XP_054194594.1  zinc finger and SCAN domain-containing protein 20 isoform X4

  5. XM_054338620.1 → XP_054194595.1  zinc finger and SCAN domain-containing protein 20 isoform X5

  6. XM_054338615.1 → XP_054194590.1  zinc finger and SCAN domain-containing protein 20 isoform X2

  7. XM_054338617.1 → XP_054194592.1  zinc finger and SCAN domain-containing protein 20 isoform X3

  8. XM_054338621.1 → XP_054194596.1  zinc finger and SCAN domain-containing protein 20 isoform X6

  9. XM_054338622.1 → XP_054194597.1  zinc finger and SCAN domain-containing protein 20 isoform X6

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17040.3 GenPept UniProtKB/Swiss-Prot:P17040

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