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Rab11fip1 RAB11 family interacting protein 1 (class I) [ Mus musculus (house mouse) ]

Gene ID: 75767, updated on 27-Nov-2024

Summary

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Official Symbol
Rab11fip1provided by MGI
Official Full Name
RAB11 family interacting protein 1 (class I)provided by MGI
Primary source
MGI:MGI:1923017
See related
Ensembl:ENSMUSG00000031488 AllianceGenome:MGI:1923017
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rcp; 2010200K21Rik; 4833414G05Rik
Summary
Predicted to enable small GTPase binding activity. Predicted to be involved in negative regulation of adiponectin secretion and regulated exocytosis. Predicted to be located in cytosol. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to human RAB11FIP1 (RAB11 family interacting protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in lung adult (RPKM 12.6), colon adult (RPKM 11.6) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Rab11fip1 in Genome Data Viewer
Location:
8 A2; 8 15.91 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (27628801..27664707, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (27138773..27174646, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39151 Neighboring gene adhesion G protein-coupled receptor A2 Neighboring gene VISTA enhancer mm136 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:28239113-28239296 Neighboring gene BRF2, RNA polymerase III transcription initiation factor 50kDa subunit Neighboring gene RIKEN cDNA 4933416M07 gene Neighboring gene glutamic-oxaloacetic transaminase 1-like 1 Neighboring gene STARR-seq mESC enhancer starr_21022 Neighboring gene adrenergic receptor, beta 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Rab11FIP1-deficient mice develop spontaneous inflammation and show increased susceptibility to colon damage. Rathan-Kumar S, et al. Am J Physiol Gastrointest Liver Physiol, 2022 Sep 1. PMID 35819177, Free PMC Article
  2. Mutant p53 Drives Cancer Metastasis via RCP-Mediated Hsp90α Secretion. Zhang S, et al. Cell Rep, 2020 Jul 7. PMID 32640214
  3. Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion. Gundry C, et al. Nat Commun, 2017 Mar 15. PMID 28294115, Free PMC Article
  4. Degradation of NLRP3 by p62-dependent-autophagy improves cognitive function in Alzheimer's disease by maintaining the phagocytic function of microglia. Zhang D, et al. CNS Neurosci Ther, 2023 Oct. PMID 37072933, Free PMC Article
  5. Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Apr 30. PMID 15449545

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rab11FIP1-deficient mice develop spontaneous inflammation and show increased susceptibility to colon damage.
    Title: Rab11FIP1-deficient mice develop spontaneous inflammation and show increased susceptibility to colon damage.
  2. Mutant p53 Drives Cancer Metastasis via RCP-Mediated Hsp90alpha Secretion.
    Title: Mutant p53 Drives Cancer Metastasis via RCP-Mediated Hsp90α Secretion.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC159103

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of adiponectin secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulated exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in phagocytic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in recycling endosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
rab11 family-interacting protein 1
Names
Rab coupling protein
rab-coupling protein
rab11-FIP1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080813.2 → NP_001074282.1  rab11 family-interacting protein 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC119917
    Consensus CDS
    CCDS40311.1
    UniProtKB/TrEMBL
    A0A1B0GRJ0, E9Q8L9
    Related
    ENSMUSP00000058042.7, ENSMUST00000054212.7
    Conserved Domains (2) summary
    cd08682
    Location:20 → 149
    C2_Rab11-FIP_classI; C2 domain found in Rab11-family interacting proteins (FIP) class I
    pfam09457
    Location:1109 → 1156
    RBD-FIP; FIP domain

  2. NM_029423.2 → NP_083699.2  rab11 family-interacting protein 1 isoform 2

    See identical proteins and their annotated locations for NP_083699.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AC119917, BB619642, BC132094
    Consensus CDS
    CCDS52534.1
    UniProtKB/Swiss-Prot
    Q05A58, Q3UBC2, Q8BN24, Q9D620
    Related
    ENSMUSP00000033878.7, ENSMUST00000033878.14
    Conserved Domains (2) summary
    cd08682
    Location:20 → 149
    C2_Rab11-FIP_classI; C2 domain found in Rab11-family interacting proteins (FIP) class I
    pfam09457
    Location:588 → 635
    RBD-FIP; FIP domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    27628801..27664707 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154355.1 → XP_036010248.1  rab11 family-interacting protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A1B0GRJ0
    Conserved Domains (1) summary
    PHA03247
    Location:339 → 501
    PHA03247; large tegument protein UL36; Provisional

  2. XM_036154353.1 → XP_036010246.1  rab11 family-interacting protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A1B0GRJ0
    Related
    ENSMUSP00000147543.2, ENSMUST00000209377.2
    Conserved Domains (2) summary
    cd08682
    Location:20 → 149
    C2_Rab11-FIP_classI; C2 domain found in Rab11-family interacting proteins (FIP) class I
    PHA03247
    Location:489 → 651
    PHA03247; large tegument protein UL36; Provisional

  3. XM_036154356.1 → XP_036010249.1  rab11 family-interacting protein 1 isoform X3

    Conserved Domains (1) summary
    cd08682
    Location:20 → 149
    C2_Rab11-FIP_classI; C2 domain found in Rab11-family interacting proteins (FIP) class I
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D620.2 GenPept UniProtKB/Swiss-Prot:Q9D620

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