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ZNF182 zinc finger protein 182 [ Homo sapiens (human) ]

Gene ID: 7569, updated on 27-Nov-2024

Summary

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Official Symbol
ZNF182provided by HGNC
Official Full Name
zinc finger protein 182provided by HGNC
Primary source
HGNC:HGNC:13001
See related
Ensembl:ENSG00000147118 MIM:314993; AllianceGenome:HGNC:13001
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KOX14; ZNF21; HHZ150; Zfp182
Summary
Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This gene encodes a zinc finger protein, and belongs to the krueppel C2H2-type zinc-finger protein family. It may be involved in transcriptional regulation. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, May 2010]
Expression
Ubiquitous expression in thyroid (RPKM 3.7), lymph node (RPKM 3.6) and 25 other tissues See more
Orthologs
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Genomic context

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See ZNF182 in Genome Data Viewer
Location:
Xp11.23
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (47974851..48003989, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (47385028..47414166, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (47834250..47863388, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:47665811-47666441 Neighboring gene MED14-independent group 3 enhancer GRCh37_chrX:47675037-47676236 Neighboring gene WASP family member 4, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29598 Neighboring gene ribosomal protein L7 pseudogene 57 Neighboring gene zinc finger protein 81 Neighboring gene CRISPRi-FlowFISH-validated HDAC6 regulatory element 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29599 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29600 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20813 Neighboring gene sperm acrosome associated 5 Neighboring gene ZNF630 antisense RNA 1 Neighboring gene zinc finger protein 630

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Localization of a novel zinc finger gene to the human chromosome 7p11.2-p12 by fluorescence in situ hybridization. Wang R, et al. Somat Cell Mol Genet, 1996 May. PMID 8914609
  2. Clustered organization of Krüppel zinc-finger genes at Xp11.23, flanking a translocation breakpoint at OATL1: a physical map with locus assignments for ZNF21, ZNF41, ZNF81, and ELK1. Knight JC, et al. Genomics, 1994 May 1. PMID 8088786
  3. Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering. Huebner K, et al. Am J Hum Genet, 1991 Apr. PMID 2014798, Free PMC Article
  4. Liganded ERα Stimulates the E3 Ubiquitin Ligase Activity of UBE3C to Facilitate Cell Proliferation. Okada M, et al. Mol Endocrinol, 2015 Nov. PMID 26389696, Free PMC Article
  5. Multiple genes encoding zinc finger domains are expressed in human T cells. Thiesen HJ. New Biol, 1990 Apr. PMID 2288909

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of zinc finger protein 182 (ZNF182) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ98691, MGC125383, MGC131713

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 182
Names
zinc finger protein 21 (KOX 14)
zinc finger protein KOX14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021254.2 RefSeqGene

    Range
    5000..34138
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001007088.2 → NP_001007089.1  zinc finger protein 182 isoform 2

    See identical proteins and their annotated locations for NP_001007089.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal exon in the 5' region, resulting in an upstream AUG start codon, as compared to variant 1. The encoded isoform 2 is shorter and has an alternate N-terminus, as compared to isoform 1.
    Source sequence(s)
    AC244636, AK122874, AW291763, BX648401, CN311292
    Consensus CDS
    CCDS35235.1
    UniProtKB/Swiss-Prot
    P17025
    Related
    ENSP00000366142.4, ENST00000376943.8
    Conserved Domains (3) summary
    smart00349
    Location:8 → 66
    KRAB; krueppel associated box
    COG5048
    Location:213 → 601
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:525 → 545
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001178099.2 → NP_001171570.1  zinc finger protein 182 isoform 1

    See identical proteins and their annotated locations for NP_001171570.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an additional segment in the 5' UTR, as compared to variant 1. This variant and variant 1 encode the same isoform (1).
    Source sequence(s)
    AK122874, BC114216, DC377274
    Consensus CDS
    CCDS35236.1
    UniProtKB/Swiss-Prot
    A2IDD7, P17025, Q3KP67, Q96QH7
    Related
    ENSP00000380165.1, ENST00000396965.5
    Conserved Domains (6) summary
    smart00349
    Location:27 → 85
    KRAB; krueppel associated box
    COG5048
    Location:147 → 553
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:544 → 564
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:374 → 396
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:27 → 66
    KRAB; KRAB box
    pfam13465
    Location:587 → 609
    zf-H2C2_2; Zinc-finger double domain

  3. NM_006962.2 → NP_008893.1  zinc finger protein 182 isoform 1

    See identical proteins and their annotated locations for NP_008893.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC244636, AK122874, AW291763, BX648401, CD642892
    Consensus CDS
    CCDS35236.1
    UniProtKB/Swiss-Prot
    A2IDD7, P17025, Q3KP67, Q96QH7
    Conserved Domains (6) summary
    smart00349
    Location:27 → 85
    KRAB; krueppel associated box
    COG5048
    Location:147 → 553
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:544 → 564
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:374 → 396
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:27 → 66
    KRAB; KRAB box
    pfam13465
    Location:587 → 609
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    47974851..48003989 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    47385028..47414166 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17025.2 GenPept UniProtKB/Swiss-Prot:P17025

Gene LinkOut

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