Prl7b1 prolactin family 7, subfamily b, member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prl7b1provided by MGI
Official Full Name: prolactin family 7, subfamily b, member 1provided by MGI
Primary source: MGI:MGI:1922846
See related: Ensembl:ENSMUSG00000021347 AllianceGenome:MGI:1922846
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ghd17; PLP-N; Prlpn; 1600014J19Rik
Summary: Predicted to enable hormone activity and prolactin receptor binding activity. Predicted to be involved in several processes, including female pregnancy; positive regulation of lactation; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in extraembryonic component and reproductive system. [provided by Alliance of Genome Resources, Jan 2025]
Expression: Restricted expression toward placenta adult (RPKM 58.6) See more
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Genomic context

Location:: 13 A3.1; 13 12.55 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (27785795..27794565, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (27601812..27610582, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PRL7B1 is viewed as a part of a pathway regulating placental adaptations to physiological stressors.
Title: A Prolactin Family Paralog Regulates Placental Adaptations to a Physiological Stressor.
Invading mouse trophoblast cells possess endocrine activities, including the expression of PLP-N.
Title: Gestation stage-dependent intrauterine trophoblast cell invasion in the rat and mouse: novel endocrine phenotype and regulation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables prolactin receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in female pregnancy	IBA Inferred from Biological aspect of Ancestor more info
involved_in mammary gland development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of lactation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to nutrient levels	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: prolactin-7B1

Names: PRL-like protein N; growth hormone d17; placental prolactin-like protein N; prolactin-like protein N

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029355.2 → NP_083631.1 prolactin-7B1 precursor

See identical proteins and their annotated locations for NP_083631.1

Status: PROVISIONAL

Source sequence(s)

AK005458

Consensus CDS

CCDS26402.1

UniProtKB/Swiss-Prot

Q14AN3, Q8CGZ9, Q9DAX1

UniProtKB/TrEMBL

A0A0M6L0K6

Related

ENSMUSP00000079431.3, ENSMUST00000080595.3

Conserved Domains (1) summary

cd10288
Location:30 → 241

prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

27785795..27794565 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011244357.2 → XP_011242659.1 prolactin-7B1 isoform X1

Conserved Domains (1) summary

cd10288
Location:1 → 164

prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones