Cmtm2b CKLF-like MARVEL transmembrane domain containing 2B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cmtm2bprovided by MGI
Official Full Name: CKLF-like MARVEL transmembrane domain containing 2Bprovided by MGI
Primary source: MGI:MGI:2447311
See related: Ensembl:ENSMUSG00000035785 AllianceGenome:MGI:2447311
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cklfsf22; Cklfsf2b; 1700013O04Rik
Summary: Predicted to enable cytokine activity. Predicted to be involved in chemotaxis and signal transduction. Predicted to be located in extracellular space. Predicted to be active in membrane. Orthologous to human CMTM2 (CKLF like MARVEL transmembrane domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward testis adult (RPKM 279.9) See more
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Genomic context

Location:: 8 D3; 8 53.04 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (105048838..105057396)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (104322206..104330764)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

co-expression of sperm membrane proteins CMTM2A and CMTM2B is required for male fertility and affects the localization of the sperm membrane protein ADAM3 in regulating sperm fertilizing ability.
Title: Co-expression of sperm membrane proteins CMTM2A and CMTM2B is essential for ADAM3 localization and male fertility in mice.
These findings suggest that CKLFSF2B might be involved in the development and function of Leydig cells and regulate testicular testosterone production by fine-tuning the expression of steroidogenic genes
Title: The expression of CKLFSF2B is regulated by GATA1 and CREB in the Leydig cells, which modulates testicular steroidogenesis.
Data show that mouse Cklfsf2a and Cklfsf2b are two homologues of human CKLFSF2.
Title: Molecular cloning and identification of mouse Cklfsf2a and Cklfsf2b, two homologues of human CKLFSF2.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: CKLF-like MARVEL transmembrane domain-containing protein 2B

Names: chemokine-like factor super family 2B; chemokine-like factor superfamily member 2B; chemokine-like factor superfamily protein 2-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028524.3 → NP_082800.1 CKLF-like MARVEL transmembrane domain-containing protein 2B

See identical proteins and their annotated locations for NP_082800.1

Status: VALIDATED

Source sequence(s)

AC121952, AK005970, BC050983

Consensus CDS

CCDS22576.1

UniProtKB/Swiss-Prot

Q9DAC0

Related

ENSMUSP00000043127.6, ENSMUST00000041973.7

Conserved Domains (1) summary

pfam01284
Location:35 → 120

MARVEL; Membrane-associating domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

105048838..105057396

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006531455.4 → XP_006531518.1 CKLF-like MARVEL transmembrane domain-containing protein 2B isoform X1

Conserved Domains (1) summary

cl04571
Location:35 → 120

MARVEL; Membrane-associating domain