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Atf7ip2 activating transcription factor 7 interacting protein 2 [ Mus musculus (house mouse) ]

Gene ID: 75329, updated on 27-Nov-2024

Summary

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Official Symbol
Atf7ip2provided by MGI
Official Full Name
activating transcription factor 7 interacting protein 2provided by MGI
Primary source
MGI:MGI:1922579
See related
Ensembl:ENSMUSG00000039200 AllianceGenome:MGI:1922579
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PSM2; Get-1; 4930558K11Rik
Summary
Predicted to enable transcription coregulator activity. Predicted to be involved in positive regulation of DNA methylation-dependent heterochromatin formation and regulation of DNA-templated transcription. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including genitourinary system; gut; heart; liver; and lung. Orthologous to human ATF7IP2 (activating transcription factor 7 interacting protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 1.2), placenta adult (RPKM 0.6) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Atf7ip2 in Genome Data Viewer
Location:
16 A1; 16 5.5 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (10010513..10068595)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (10192649..10250731)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_40070 Neighboring gene STARR-seq mESC enhancer starr_40071 Neighboring gene STARR-seq mESC enhancer starr_40072 Neighboring gene STARR-seq mESC enhancer starr_40073 Neighboring gene ribosomal protein L39-like Neighboring gene STARR-seq mESC enhancer starr_40074 Neighboring gene STARR-seq mESC enhancer starr_40076 Neighboring gene predicted gene, 24667 Neighboring gene epithelial membrane protein 2 Neighboring gene STARR-seq mESC enhancer starr_40077 Neighboring gene predicted gene 1600

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ATF7IP2, a meiosis-specific partner of SETDB1, is required for proper chromosome remodeling and crossover formation during spermatogenesis. Shao Q, et al. Cell Rep, 2023 Aug 29. PMID 37542719
  2. PSM2, a novel protein similar to MCAF2, is involved in the mouse embryonic and adult male gonad development. Cai H, et al. Mol Biol Rep, 2006 Sep. PMID 16850184
  3. Global gene expression analysis in fetal mouse ovaries with and without meiosis and comparison of selected genes with meiosis in the testis. Olesen C, et al. Cell Tissue Res, 2007 Apr. PMID 17431699
  4. Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation. Barnes CE, et al. Mol Omics, 2022 Jan 17. PMID 34709266, Free PMC Article
  5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC6783

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
activating transcription factor 7-interacting protein 2
Names
MBD1-containing chromatin-associated factor 2
protein similar to MCAF2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029253.1 → NP_083529.1  activating transcription factor 7-interacting protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses different segments for its 3' coding region and 3' UTR, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus when it is compared to isoform 1.
    Source sequence(s)
    AK016180, AK145634
    Consensus CDS
    CCDS49759.1
    UniProtKB/Swiss-Prot
    Q3UL97
    Related
    ENSMUSP00000113480.2, ENSMUST00000119023.8
    Conserved Domains (1) summary
    pfam16788
    Location:59 → 260
    ATF7IP_BD; ATF-interacting protein binding domain

  2. NM_153123.2 → NP_694763.2  activating transcription factor 7-interacting protein 2 isoform 1

    See identical proteins and their annotated locations for NP_694763.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AC154311, AK145634, BY715784
    Consensus CDS
    CCDS49758.1
    UniProtKB/Swiss-Prot
    Q3UL97, Q3UT16, Q4VIF3, Q8BPC5, Q9D4T8
    Related
    ENSMUSP00000036731.8, ENSMUST00000044005.14
    Conserved Domains (2) summary
    pfam16788
    Location:59 → 260
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:345 → 443
    fn3_4; Fibronectin-III type domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    10010513..10068595
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246039.3 → XP_011244341.1  activating transcription factor 7-interacting protein 2 isoform X2

    Conserved Domains (1) summary
    pfam16788
    Location:59 → 264
    ATF7IP_BD; ATF-interacting protein binding domain

  2. XM_006522684.4 → XP_006522747.1  activating transcription factor 7-interacting protein 2 isoform X3

    Conserved Domains (1) summary
    pfam16788
    Location:59 → 264
    ATF7IP_BD; ATF-interacting protein binding domain

  3. XM_006522682.3 → XP_006522745.1  activating transcription factor 7-interacting protein 2 isoform X1

    Conserved Domains (2) summary
    pfam16788
    Location:59 → 223
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:304 → 402
    fn3_4; Fibronectin-III type domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UL97.1 GenPept UniProtKB/Swiss-Prot:Q3UL97

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