NFKB1 nuclear factor kappa B subunit 1 [Sus scrofa (pig)] - Gene

Summary

Official Symbol: NFKB1provided by VGNC
Official Full Name: nuclear factor kappa B subunit 1provided by VGNC
Primary source: VGNC:VGNC:90719
See related: Ensembl:ENSSSCG00000030957
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression: Ubiquitous expression in spleen (RPKM 32.5), lung (RPKM 23.6) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	8	NC_010450.4 (118391010..118478927, complement)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	8	NC_010450.3 (127365561..127368964)

Chromosome 8 - NC_010450.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Suppressor of cytokine signaling 1 (SOCS1) inhibits antiviral responses to facilitate Senecavirus A infection by regulating the NF-kappaB signaling pathway.
Title: Suppressor of cytokine signaling 1 (SOCS1) inhibits antiviral responses to facilitate Senecavirus A infection by regulating the NF-κB signaling pathway.
endotracheal tube presence was characterized by neutrophil activation, necrosis, and release of proinflammatory cytokines mediated by TLR9/NF-kappaB induction.
Title: Endotracheal intubation results in acute tracheal damage induced by mtDNA/TLR9/NF-κB activity.
Actinobacillus pleuropneumoniae induces alveolar Macrophages to produce proinflammatory cytokines via upregulation of TLR4 and NF-kappaB.
Title: Activation of Porcine Alveolar Macrophages by Actinobacillus pleuropneumoniae Lipopolysaccharide via the Toll-Like Receptor 4/NF-κB-Mediated Pathway.
Here, heat shock protein 27 (Hsp27) has been identified as a novel binding partner of NS5A, a protein functioning in classical swine fever virus genome replication. Further findings clearly demonstrate that the inhibition of viral replication by Hsp27 is mediated via the NF-kappaB signaling pathway.
Title: Cellular Hsp27 interacts with classical swine fever virus NS5A protein and negatively regulates viral replication by the NF-κB signaling pathway.
Porcine parvovirus virus infection significantly induced IL-6 expression and this induction depended on NF-kappaB activation and TLR9 signaling pathways in PK-15 cell.
Title: Porcine parvovirus infection activates inflammatory cytokine production through Toll-like receptor 9 and NF-κB signaling pathways in porcine kidney cells.
This study showed that porcine epidemic diarrhea virus inhibited NF-kappaB activity and nsp1 was a potent NF-kappaB antagonist for suppression of both interferon and early production of pro-inflammatory cytokines.
Title: Inhibition of NF-κB activity by the porcine epidemic diarrhea virus nonstructural protein 1 for innate immune evasion.
inhibition of NF-kappaB increases autophagy via JNK signaling, and promotes steroidogenesis in porcine granulosa cells
Title: Inhibition of NF-κB promotes autophagy via JNK signaling pathway in porcine granulosa cells.
SIRT1, p53 and NF-kappaB are involved in the control of both the proliferation and the apoptosis of ovarian cells.
Title: Interrelationships between sirtuin 1 and transcription factors p53 and NF-κB (p50/p65) in the control of ovarian cell apoptosis and proliferation.
porcine CD74 significantly enhanced the inflammatory response by regulating the NF-kappaB signalling pathway during PCV2 infection, which suggests that porcine CD74 may be implicated in the pathogenesis of PCV2 infection.
Title: Porcine CD74 is involved in the inflammatory response activated by nuclear factor kappa B during porcine circovirus type 2 (PCV-2) infection.
These results suggest that trans-10, cis-12-conjugated linoleic acid can modulate TNF-alpha production and NF-kappa B expression by a PPARgamma-dependent pathway in porcine peripheral blood mononuclear cells.
Title: Trans-10, cis-12-conjugated linoleic acid modulates NF-κB activation and TNF-α production in porcine peripheral blood mononuclear cells via a PPARγ-dependent pathway.

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General gene information

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Markers

MARC_3148-3149:996679038:1 (e-PCR)
- UniSTS:269181

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to stress	IEA Inferred from Electronic Annotation more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in non-canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to cytokine	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: nuclear factor NF-kappa-B p105 subunit

Names: RHD of nuclear factor NF-kappa-B p105 subunit; nuclear factor NF-kappa-B p50 subunit; nuclear factor kappa-B 1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001048232.1 → NP_001041697.1 nuclear factor NF-kappa-B p105 subunit

See identical proteins and their annotated locations for NP_001041697.1

Status: PROVISIONAL

Source sequence(s)

DQ834921

UniProtKB/TrEMBL

A0A480I433, Q0PHA8

Related

ENSSSCP00000048015.2, ENSSSCT00000038683.3

Conserved Domains (8) summary

cd07935
Location:29 → 230

RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)

cd00204
Location:560 → 689

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd01177
Location:237 → 338

IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...

cd08797
Location:800 → 874

Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105

pfam12796
Location:570 → 664

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:527 → 586

Ank_4; Ankyrin repeats (many copies)

pfam13857
Location:656 → 710

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:526 → 563

ANK; ANK repeat [structural motif]