gck glucokinase (hexokinase 4) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gckprovided by ZNC
Official Full Name: glucokinase (hexokinase 4)provided by ZNC
Primary source: ZFIN:ZDB-GENE-060825-204
See related: Ensembl:ENSDARG00000068006 AllianceGenome:ZFIN:ZDB-GENE-060825-204
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: glk; hex4; fb57f10; wu:fb57f10; zgc:153643
Summary: Predicted to enable fructokinase activity; glucokinase activity; and mannokinase activity. Acts upstream of or within glucose homeostasis; pancreas regeneration; and type B pancreatic cell development. Predicted to be active in cytosol and mitochondrion. Is expressed in several structures, including digestive system; female organism; heart; male organism; and muscle. Human ortholog(s) of this gene implicated in artery disease (multiple) and glucose metabolism disease (multiple). Orthologous to human GCK (glucokinase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (40477264..40490579)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (40437679..40450994)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb57f10.x1 (e-PCR)
- UniSTS:190790

fb57f10 (e-PCR), detects polymorphism
- UniSTS:187235

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables D-glucose binding	IEA Inferred from Electronic Annotation more info
enables fructokinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucokinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hexokinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables mannokinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phosphotransferase activity, alcohol group as acceptor	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endocrine pancreas development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose 6-phosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycolytic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glycolytic process	IEA Inferred from Electronic Annotation more info
involved_in glycolytic process	IEA Inferred from Electronic Annotation more info
involved_in intracellular glucose homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intracellular glucose homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pancreas regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of insulin secretion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within type B pancreatic cell development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: hexokinase-4

Names: glucokinase (hexokinase 4, maturity onset diabetes of the young 2)

NP_001038850.2

EC 2.7.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045385.2 → NP_001038850.2 hexokinase-4

Status: VALIDATED

Source sequence(s)

BX248505, FO904822

UniProtKB/TrEMBL

A0A8M1NAW0, F1RC38

Related

ENSDARP00000112428.2, ENSDART00000129772.3

Conserved Domains (3) summary

COG5026
Location:26 → 468

COG5026; Hexokinase [Carbohydrate transport and metabolism]

pfam00349
Location:26 → 225

Hexokinase_1; Hexokinase

pfam03727
Location:231 → 465

Hexokinase_2; Hexokinase