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kmt5aa lysine methyltransferase 5Aa [ Danio rerio (zebrafish) ]

Gene ID: 751629, updated on 9-Dec-2024

Summary

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Official Symbol
kmt5aaprovided by ZNC
Official Full Name
lysine methyltransferase 5Aaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060825-37
See related
Ensembl:ENSDARG00000105231 AllianceGenome:ZFIN:ZDB-GENE-060825-37
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
set8a; setd8a; wu:fj33f02; zgc:153719
Summary
Predicted to enable histone H4K20 methyltransferase activity. Acts upstream of or within dorsal/ventral pattern formation and positive regulation of gene expression. Predicted to be located in chromosome. Predicted to be active in nucleus and polytene chromosome. Is expressed in blastoderm; blastodisc; brain; and intermediate cell mass of mesoderm. Orthologous to human KMT5A (lysine methyltransferase 5A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See kmt5aa in Genome Data Viewer
Location:
chromosome: 10
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (44363180..44372381)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (44446488..44455689)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene zinc finger, SWIM-type containing 6 Neighboring gene cyclin dependent kinase 2 associated protein 1 Neighboring gene strawberry notch homolog 1 (Drosophila) Neighboring gene small nuclear ribonucleoprotein 35 (U11/U12) Neighboring gene CAP-GLY domain containing linker protein 1b Neighboring gene density-regulated protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Histone H4 Lys 20 monomethylation by histone methylase SET8 mediates Wnt target gene activation. Li Z, et al. Proc Natl Acad Sci U S A, 2011 Feb 22. PMID 21282610, Free PMC Article
  2. Genome-wide survey and developmental expression mapping of zebrafish SET domain-containing genes. Sun XJ, et al. PLoS One, 2008 Jan 30. PMID 18231586, Free PMC Article
  3. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
  4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC153719

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables histone H4K20 methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H4K20 methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4K20 monomethyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within dorsal/ventral pattern formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within dorsal/ventral pattern formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA damage response, signal transduction by p53 class mediator IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in polytene chromosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
N-lysine methyltransferase KMT5A-A
Names
N-lysine methyltransferase SETD8-A
PR/SET domain containing protein 8a
SET domain containing (lysine methyltransferase) 8a
SET domain-containing 8
SET domain-containing protein 8-A
histone-lysine N-methyltransferase KMT5A-A
histone-lysine N-methyltransferase SETD8-A
lysine-specific methylase 5A-A
NP_001038814.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045349.2 → NP_001038814.2  N-lysine methyltransferase KMT5A-A

    See identical proteins and their annotated locations for NP_001038814.2

    Status: PROVISIONAL

    Source sequence(s)
    DQ343297
    UniProtKB/Swiss-Prot
    Q071E0, Q0P3X5
    Related
    ENSDARP00000140543.1, ENSDART00000161744.3
    Conserved Domains (1) summary
    smart00317
    Location:212 → 334
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    44363180..44372381
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q071E0.1 GenPept UniProtKB/Swiss-Prot:Q071E0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.