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Cfap210 cilia and flagella associated protein 210 [ Mus musculus (house mouse) ]

Gene ID: 75051, updated on 27-Nov-2024

Summary

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Official Symbol
Cfap210provided by MGI
Official Full Name
cilia and flagella associated protein 210provided by MGI
Primary source
MGI:MGI:1923100
See related
Ensembl:ENSMUSG00000070883 AllianceGenome:MGI:1923100
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ccdc173; 4930525K21Rik; 4930578N16Rik
Summary
Involved in flagellated sperm motility. Is active in axonemal B tubule inner sheath and sperm flagellum. Orthologous to human CFAP210 (cilia and flagella associated protein 210). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 3.4), CNS E11.5 (RPKM 1.2) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Cfap210 in Genome Data Viewer
Location:
2 C2; 2 40.95 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (69587736..69619873, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (69757392..69789617, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene FAST kinase domains 1 Neighboring gene STARR-seq mESC enhancer starr_04743 Neighboring gene STARR-positive B cell enhancer ABC_E10110 Neighboring gene peptidyl-prolyl isomerase G (cyclophilin G) Neighboring gene STARR-positive B cell enhancer mm9_chr2:69582878-69583179 Neighboring gene 60S ribosomal protein L13-like Neighboring gene STARR-seq mESC enhancer starr_04744 Neighboring gene STARR-positive B cell enhancer ABC_E4461 Neighboring gene phosphatase, orphan 2 Neighboring gene predicted gene 13624

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. De novo protein identification in mammalian sperm using in situ cryoelectron tomography and AlphaFold2 docking. Chen Z, et al. Cell, 2023 Nov 9. PMID 37865089, Free PMC Article
  2. In-cell structural insight into the stability of sperm microtubule doublet. Tai L, et al. Cell Discov, 2023 Nov 21. PMID 37989994, Free PMC Article
  3. Structures of sperm flagellar doublet microtubules expand the genetic spectrum of male infertility. Zhou L, et al. Cell, 2023 Jun 22. PMID 37295417
  4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in flagellated sperm motility IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in axonemal B tubule inner sheath IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in axonemal microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axonemal microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in axonemal microtubule ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in sperm flagellum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cilia- and flagella- associated protein 210
Names
coiled-coil domain containing 173
coiled-coil domain-containing protein 173
protein CFAP210

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077684.2 → NP_001071152.1  cilia- and flagella- associated protein 210 isoform 1

    See identical proteins and their annotated locations for NP_001071152.1

    Status: VALIDATED

    Source sequence(s)
    AL845261
    Consensus CDS
    CCDS38138.1
    UniProtKB/Swiss-Prot
    A0JLY1
    UniProtKB/TrEMBL
    B7ZN54
    Related
    ENSMUSP00000092548.4, ENSMUST00000094942.4
    Conserved Domains (1) summary
    pfam13868
    Location:142 → 466
    TPH; Trichohyalin-plectin-homology domain

  2. NM_001418782.1 → NP_001405711.1  cilia- and flagella- associated protein 210 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL845261

RNA

  1. NR_184817.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL845261

  2. NR_184818.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL845261

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    69587736..69619873 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239823.1 → XP_011238125.1  cilia- and flagella- associated protein 210 isoform X1

    See identical proteins and their annotated locations for XP_011238125.1

    Conserved Domains (1) summary
    pfam13868
    Location:62 → 295
    TPH; Trichohyalin-plectin-homology domain

  2. XM_006500324.3 → XP_006500387.1  cilia- and flagella- associated protein 210 isoform X2

    Conserved Domains (1) summary
    pfam13868
    Location:1 → 230
    TPH; Trichohyalin-plectin-homology domain

  3. XM_006500322.3 → XP_006500385.1  cilia- and flagella- associated protein 210 isoform X1

    See identical proteins and their annotated locations for XP_006500385.1

    Conserved Domains (1) summary
    pfam13868
    Location:62 → 295
    TPH; Trichohyalin-plectin-homology domain

  4. XM_006500325.5 → XP_006500388.1  cilia- and flagella- associated protein 210 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0JLY1.1 GenPept UniProtKB/Swiss-Prot:A0JLY1

Gene LinkOut

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