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Iqca1 IQ motif containing with AAA domain 1 [ Mus musculus (house mouse) ]

Gene ID: 74918, updated on 27-Nov-2024

Summary

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Official Symbol
Iqca1provided by MGI
Official Full Name
IQ motif containing with AAA domain 1provided by MGI
Primary source
MGI:MGI:1922168
See related
Ensembl:ENSMUSG00000026301 AllianceGenome:MGI:1922168
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Iqca; 4930465P12Rik; 4930585L22Rik
Summary
Predicted to enable ATP binding activity and ATP hydrolysis activity. Predicted to be located in cytoplasm; cytoskeleton; and motile cilium. Is expressed in lung. Orthologous to human IQCA1 (IQ motif containing with AAA domain 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 3.5), lung adult (RPKM 0.8) and 2 other tissues See more
Orthologs
human all
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Genomic context

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See Iqca1 in Genome Data Viewer
Location:
1 D; 1 45.08 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (89969854..90081158, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (90042132..90153436, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and SOCS box-containing 18 Neighboring gene predicted gene, 41915 Neighboring gene predicted gene, 34616 Neighboring gene STARR-seq mESC enhancer starr_01676 Neighboring gene RIKEN cDNA 4930434B07 gene Neighboring gene STARR-seq mESC enhancer starr_01677 Neighboring gene atypical chemokine receptor 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CRISPR/Cas9-based genome editing in mice uncovers 13 testis- or epididymis-enriched genes individually dispensable for male reproduction†. Sun J, et al. Biol Reprod, 2020 Aug 4. PMID 32588039, Free PMC Article
  2. Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Stauber M, et al. Dev Biol, 2017 Mar 15. PMID 27914912
  3. Single-cell transcriptomic analysis of mouse neocortical development. Loo L, et al. Nat Commun, 2019 Jan 11. PMID 30635555, Free PMC Article
  4. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dynein regulatory complex protein 11
Names
IQ and AAA domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368722.1 → NP_001355651.1  dynein regulatory complex protein 11 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC110261, AC124227
    UniProtKB/Swiss-Prot
    Q3UT65, Q9CUL5, Q9D4P1
    Related
    ENSMUSP00000148643.2, ENSMUST00000212394.2
    Conserved Domains (1) summary
    COG0464
    Location:578 → 797
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]

  2. NM_029122.3 → NP_083398.2  dynein regulatory complex protein 11 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC110261, AC124227
    Consensus CDS
    CCDS48317.1
    UniProtKB/Swiss-Prot
    Q3UT65, Q9CUL5, Q9D4P1
    UniProtKB/TrEMBL
    E9QMY8
    Related
    ENSMUSP00000108717.3, ENSMUST00000113094.9
    Conserved Domains (2) summary
    COG0464
    Location:569 → 788
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
    pfam00004
    Location:571 → 704
    AAA; ATPase family associated with various cellular activities (AAA)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    89969854..90081158 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001033777.1: Suppressed sequence

    Description
    NM_001033777.1: This RefSeq was removed because the CDS is partial.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CUL5.2 GenPept UniProtKB/Swiss-Prot:Q9CUL5

Gene LinkOut

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