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Rab3il1 RAB3A interacting protein (rabin3)-like 1 [ Mus musculus (house mouse) ]

Gene ID: 74760, updated on 27-Nov-2024

Summary

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Official Symbol
Rab3il1provided by MGI
Official Full Name
RAB3A interacting protein (rabin3)-like 1provided by MGI
Primary source
MGI:MGI:1922010
See related
Ensembl:ENSMUSG00000024663 AllianceGenome:MGI:1922010
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rab3ail1; 1200014K04Rik
Summary
Predicted to enable guanyl-nucleotide exchange factor activity; identical protein binding activity; and kinase binding activity. Predicted to be involved in exocytosis. Predicted to be active in Golgi to plasma membrane transport vesicle. Is expressed in cerebral cortex ventricular layer; cortical plate; and embryo. Orthologous to human RAB3IL1 (RAB3A interacting protein like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 100.1), liver E14.5 (RPKM 29.4) and 10 other tissues See more
Orthologs
human all
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Genomic context

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See Rab3il1 in Genome Data Viewer
Location:
19 A; 19 6.26 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (9979033..10015744)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (10001669..10038380)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36913 Neighboring gene ferritin heavy polypeptide 1 Neighboring gene STARR-positive B cell enhancer mm9_chr19:10074872-10075172 Neighboring gene bestrophin 1 Neighboring gene fatty acid desaturase 3 Neighboring gene predicted gene, 29917 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:10138709-10138947 Neighboring gene fatty acid desaturase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. GRAB is a binding partner for the Rab11a and Rab11b GTPases. Horgan CP, et al. Biochem Biophys Res Commun, 2013 Nov 8. PMID 24140058
  2. A Phosphoproteomic Screen Identifies a Guanine Nucleotide Exchange Factor for Rab3A Protein as a Mitogen-activated Protein (MAP) Kinase Phosphatase-5-regulated MAP Kinase Target in Interleukin 6 (IL-6) Secretion and Myogenesis. Lee H, et al. J Biol Chem, 2017 Mar 3. PMID 28096466, Free PMC Article
  3. Identification of a heterogeneous and dynamic ciliome during embryonic development and cell differentiation. Elliott KH, et al. Development, 2023 Apr 15. PMID 36971348, Free PMC Article
  4. Grab regulates transferrin receptor recycling and iron uptake in developing erythroblasts. Chen M, et al. Blood, 2022 Sep 8. PMID 35820059
  5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Grab regulates transferrin receptor recycling and iron uptake in developing erythroblasts.
    Title: Grab regulates transferrin receptor recycling and iron uptake in developing erythroblasts.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
guanine nucleotide exchange factor for Rab-3A
Names
guanine nucleotide exchange factor for Rab3A
rab-3A-interacting-like protein 1
rab3A-interacting-like protein 1
rabin3-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347429.1 → NP_001334358.1  guanine nucleotide exchange factor for Rab-3A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC134437, AK161298
    Consensus CDS
    CCDS84417.1
    UniProtKB/Swiss-Prot
    Q8VDV3
    Related
    ENSMUSP00000113828.2, ENSMUST00000121418.8
    Conserved Domains (2) summary
    pfam06428
    Location:23 → 91
    Sec2p; GDP/GTP exchange factor Sec2p
    cl41767
    Location:148 → 310
    Rab11BD_RAB3IP_like; Rab11 binding domain of Rab-3A-interacting protein (RAB3IP), Rab-3A-interacting-like protein 1 (RAB3IL1) and similar proteins

  2. NM_001347430.1 → NP_001334359.1  guanine nucleotide exchange factor for Rab-3A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC134437, AK004767
    Consensus CDS
    CCDS84416.1
    UniProtKB/TrEMBL
    D3Z585
    Related
    ENSMUSP00000113551.2, ENSMUST00000117641.8

  3. NM_001378857.1 → NP_001365786.1  guanine nucleotide exchange factor for Rab-3A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC134437
    Conserved Domains (2) summary
    pfam06428
    Location:23 → 91
    Sec2p; GDP/GTP exchange factor Sec2p
    cl41767
    Location:148 → 310
    Rab11BD_RAB3IP_like; Rab11 binding domain of Rab-3A-interacting protein (RAB3IP), Rab-3A-interacting-like protein 1 (RAB3IL1) and similar proteins

  4. NM_001378858.1 → NP_001365787.1  guanine nucleotide exchange factor for Rab-3A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC134437
    Conserved Domains (2) summary
    pfam06428
    Location:23 → 91
    Sec2p; GDP/GTP exchange factor Sec2p
    cl41767
    Location:148 → 310
    Rab11BD_RAB3IP_like; Rab11 binding domain of Rab-3A-interacting protein (RAB3IP), Rab-3A-interacting-like protein 1 (RAB3IL1) and similar proteins

  5. NM_001378859.1 → NP_001365788.1  guanine nucleotide exchange factor for Rab-3A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC134437
    UniProtKB/TrEMBL
    A0A571BDP7
    Related
    ENSMUSP00000158807.2, ENSMUST00000238672.2
    Conserved Domains (2) summary
    pfam06428
    Location:92 → 160
    Sec2p; GDP/GTP exchange factor Sec2p
    cl41767
    Location:267 → 428
    Rab11BD_RAB3IP_like; Rab11 binding domain of Rab-3A-interacting protein (RAB3IP), Rab-3A-interacting-like protein 1 (RAB3IL1) and similar proteins

  6. NM_001378860.1 → NP_001365789.1  guanine nucleotide exchange factor for Rab-3A isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC134437
    Conserved Domains (2) summary
    pfam06428
    Location:139 → 190
    Sec2p; GDP/GTP exchange factor Sec2p
    cl41767
    Location:194 → 353
    Rab11BD_RAB3IP_like; Rab11 binding domain of Rab-3A-interacting protein (RAB3IP), Rab-3A-interacting-like protein 1 (RAB3IL1) and similar proteins

  7. NM_001378861.1 → NP_001365790.1  guanine nucleotide exchange factor for Rab-3A isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC134437
    Conserved Domains (2) summary
    pfam06428
    Location:23 → 73
    Sec2p; GDP/GTP exchange factor Sec2p
    cl41767
    Location:78 → 237
    Rab11BD_RAB3IP_like; Rab11 binding domain of Rab-3A-interacting protein (RAB3IP), Rab-3A-interacting-like protein 1 (RAB3IL1) and similar proteins

  8. NM_144538.3 → NP_653121.1  guanine nucleotide exchange factor for Rab-3A isoform 1

    See identical proteins and their annotated locations for NP_653121.1

    Status: VALIDATED

    Source sequence(s)
    AC134437, AK161298, BB733894
    Consensus CDS
    CCDS29569.1
    UniProtKB/Swiss-Prot
    Q3TTM0, Q8VDV3
    Related
    ENSMUSP00000108786.3, ENSMUST00000113161.10
    Conserved Domains (1) summary
    pfam06428
    Location:92 → 160
    Sec2p; GDP/GTP exchange factor Sec2p

RNA

  1. NR_153790.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC134437

  2. NR_166144.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC134437

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    9979033..10015744
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161717.1 → XP_036017610.1  guanine nucleotide exchange factor for Rab-3A isoform X6

    Conserved Domains (2) summary
    pfam06428
    Location:139 → 190
    Sec2p; GDP/GTP exchange factor Sec2p
    cl41767
    Location:194 → 353
    Rab11BD_RAB3IP_like; Rab11 binding domain of Rab-3A-interacting protein (RAB3IP), Rab-3A-interacting-like protein 1 (RAB3IL1) and similar proteins

  2. XM_030251119.1 → XP_030106979.1  guanine nucleotide exchange factor for Rab-3A isoform X5

    Conserved Domains (1) summary
    pfam06428
    Location:23 → 91
    Sec2p; GDP/GTP exchange factor Sec2p

  3. XM_030251123.1 → XP_030106983.1  guanine nucleotide exchange factor for Rab-3A isoform X7

    Conserved Domains (2) summary
    pfam06428
    Location:23 → 91
    Sec2p; GDP/GTP exchange factor Sec2p
    cl41767
    Location:148 → 310
    Rab11BD_RAB3IP_like; Rab11 binding domain of Rab-3A-interacting protein (RAB3IP), Rab-3A-interacting-like protein 1 (RAB3IL1) and similar proteins

  4. XM_006527414.1 → XP_006527477.1  guanine nucleotide exchange factor for Rab-3A isoform X2

    Conserved Domains (2) summary
    pfam06428
    Location:98 → 166
    Sec2p; GDP/GTP exchange factor Sec2p
    pfam16046
    Location:30 → 164
    FAM76; FAM76 protein

  5. XM_036161716.1 → XP_036017609.1  guanine nucleotide exchange factor for Rab-3A isoform X4

    Conserved Domains (2) summary
    pfam06428
    Location:98 → 166
    Sec2p; GDP/GTP exchange factor Sec2p
    cl41767
    Location:223 → 385
    Rab11BD_RAB3IP_like; Rab11 binding domain of Rab-3A-interacting protein (RAB3IP), Rab-3A-interacting-like protein 1 (RAB3IL1) and similar proteins

  6. XM_030251120.2 → XP_030106980.1  guanine nucleotide exchange factor for Rab-3A isoform X5

    Conserved Domains (1) summary
    pfam06428
    Location:23 → 91
    Sec2p; GDP/GTP exchange factor Sec2p

  7. XM_006527412.1 → XP_006527475.1  guanine nucleotide exchange factor for Rab-3A isoform X1

    Conserved Domains (2) summary
    pfam06428
    Location:139 → 207
    Sec2p; GDP/GTP exchange factor Sec2p
    pfam16046
    Location:71 → 205
    FAM76; FAM76 protein

  8. XM_036161715.1 → XP_036017608.1  guanine nucleotide exchange factor for Rab-3A isoform X3

    UniProtKB/TrEMBL
    D3YZ86
    Related
    ENSMUSP00000120401.3, ENSMUST00000149967.9
    Conserved Domains (2) summary
    pfam06428
    Location:139 → 207
    Sec2p; GDP/GTP exchange factor Sec2p
    cl41767
    Location:264 → 426
    Rab11BD_RAB3IP_like; Rab11 binding domain of Rab-3A-interacting protein (RAB3IP), Rab-3A-interacting-like protein 1 (RAB3IL1) and similar proteins

  9. XM_011247385.4 → XP_011245687.1  guanine nucleotide exchange factor for Rab-3A isoform X5

    Conserved Domains (1) summary
    pfam06428
    Location:23 → 91
    Sec2p; GDP/GTP exchange factor Sec2p

RNA

  1. XR_877692.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VDV3.1 GenPept UniProtKB/Swiss-Prot:Q8VDV3

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