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Ptchd3 patched domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 74675, updated on 27-Nov-2024

Summary

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Official Symbol
Ptchd3provided by MGI
Official Full Name
patched domain containing 3provided by MGI
Primary source
MGI:MGI:1921925
See related
Ensembl:ENSMUSG00000039198 AllianceGenome:MGI:1921925
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RNDEu-3; 4930451E13Rik; 4933440L20Rik
Summary
Located in sperm midpiece. Orthologous to human PTCHD3 (patched domain containing 3 (gene/pseudogene)). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis adult (RPKM 19.1) See more
Orthologs
human all
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Genomic context

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See Ptchd3 in Genome Data Viewer
Location:
11 E2; 11 87.9 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (121721050..121734259)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (121830218..121843438)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene meteorin, glial cell differentiation regulator-like Neighboring gene predicted gene 12589 Neighboring gene predicted gene, 30338 Neighboring gene STARR-seq mESC enhancer starr_31386 Neighboring gene predicted gene, 57581 Neighboring gene predicted gene 12586 Neighboring gene STARR-seq mESC enhancer starr_31389 Neighboring gene predicted gene, 53212

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse Ptchd3 is a non-essential gene. González Morales SR, et al. Gene, 2020 Dec. PMID 34493359
  2. Mouse Ptchd3 is a non-essential gene. González Morales SR, et al. Gene X, 2020 Dec. PMID 32550558, Free PMC Article
  3. Male germ cell-specific expression of a novel Patched-domain containing gene Ptchd3. Fan J, et al. Biochem Biophys Res Commun, 2007 Nov 23. PMID 17904097
  4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in sperm midpiece IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm midpiece ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
patched domain-containing protein 3
Names
RND-type protein RNDEu-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029049.2 → NP_083325.1  patched domain-containing protein 3

    See identical proteins and their annotated locations for NP_083325.1

    Status: VALIDATED

    Source sequence(s)
    AL663041
    Consensus CDS
    CCDS49014.1
    UniProtKB/Swiss-Prot
    A2AC39, Q0EEE2, Q9CUM1, Q9D3R2
    Related
    ENSMUSP00000035709.7, ENSMUST00000036690.7
    Conserved Domains (2) summary
    pfam02460
    Location:127 → 906
    Patched; Patched family
    cl21543
    Location:363 → 503
    MMPL; MMPL family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    121721050..121734259
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534383.4 → XP_006534446.1  patched domain-containing protein 3 isoform X1

    UniProtKB/TrEMBL
    B7ZN87
    Conserved Domains (1) summary
    cl25655
    Location:127 → 409
    Patched; Patched family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0EEE2.1 GenPept UniProtKB/Swiss-Prot:Q0EEE2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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