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Magec2 MAGE family member C2 [ Mus musculus (house mouse) ]

Gene ID: 74437, updated on 27-Nov-2024

Summary

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Official Symbol
Magec2provided by MGI
Official Full Name
MAGE family member C2provided by MGI
Primary source
MGI:MGI:1921687
See related
Ensembl:ENSMUSG00000045330 AllianceGenome:MGI:1921687
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4933402E13Rik
Summary
Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in cranial ganglion and lung. Orthologous to human MAGEC1 (MAGE family member C1) and MAGEC2 (MAGE family member C2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward placenta adult (RPKM 43.6) See more
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Genomic context

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See Magec2 in Genome Data Viewer
Location:
X A6; X 34.57 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (61326566..61335690)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (62282960..62292084)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene crumbs homolog 1 pseudogene Neighboring gene melanoma antigen family A pseudogene Neighboring gene STARR-seq mESC enhancer starr_47257 Neighboring gene STARR-seq mESC enhancer starr_47258 Neighboring gene N-myristoyltransferase 1 pseudogene Neighboring gene RIKEN cDNA 4931400O07 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RBPJ in mouse Sertoli cells is required for proper regulation of the testis stem cell niche. Garcia TX, et al. Development, 2014 Dec. PMID 25406395, Free PMC Article
  2. Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network. Shalom-Barak T, et al. Dev Biol, 2012 Dec 1. PMID 22967998, Free PMC Article
  3. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
melanoma-associated antigen 11-like
Names
Novel transcript similar to melanoma-associated antigen 11 (MAGE-11 antigen)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199996.1 → NP_001186925.1  melanoma-associated antigen 11-like

    See identical proteins and their annotated locations for NP_001186925.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK016614
    Consensus CDS
    CCDS53078.1
    UniProtKB/TrEMBL
    Q9D4D2
    Related
    ENSMUSP00000056260.2, ENSMUST00000051414.2
    Conserved Domains (1) summary
    pfam01454
    Location:224 → 379
    MAGE; MAGE family

  2. NM_001199997.1 → NP_001186926.1  melanoma-associated antigen 11-like

    See identical proteins and their annotated locations for NP_001186926.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL831775, BY074679
    Consensus CDS
    CCDS53078.1
    UniProtKB/TrEMBL
    Q9D4D2
    Related
    ENSMUSP00000136235.2, ENSMUST00000178085.8
    Conserved Domains (1) summary
    pfam01454
    Location:224 → 379
    MAGE; MAGE family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    61326566..61335690
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528321.2 → XP_006528384.1  melanoma-associated antigen 11-like isoform X1

    See identical proteins and their annotated locations for XP_006528384.1

    UniProtKB/TrEMBL
    Q9D4D2
    Conserved Domains (1) summary
    pfam01454
    Location:224 → 379
    MAGE; MAGE family
Nucleotide Protein Strain
Heading Accession and Version

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