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Tktl2 transketolase-like 2 [ Mus musculus (house mouse) ]

Gene ID: 74419, updated on 27-Nov-2024

Summary

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Official Symbol
Tktl2provided by MGI
Official Full Name
transketolase-like 2provided by MGI
Primary source
MGI:MGI:1921669
See related
Ensembl:ENSMUSG00000025519 AllianceGenome:MGI:1921669
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4933401I19Rik
Summary
Predicted to enable thiamine pyrophosphate binding activity and transketolase activity. Predicted to be located in cytoplasm. Orthologous to human TKTL2 (transketolase like 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis adult (RPKM 7.0) See more
Orthologs
human all
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Genomic context

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See Tktl2 in Genome Data Viewer
Location:
8 B3.1; 8 33.14 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (66964392..66971851)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (66511740..66519199)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:69010363-69010546 Neighboring gene STARR-seq mESC enhancer starr_21673 Neighboring gene translation machinery associated 16 Neighboring gene predicted gene, 32568 Neighboring gene STARR-seq mESC enhancer starr_21675 Neighboring gene STARR-seq mESC enhancer starr_21676 Neighboring gene STARR-seq mESC enhancer starr_21677 Neighboring gene neuropeptide Y receptor Y5 Neighboring gene neuropeptide Y receptor Y1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice†. Lu Y, et al. Biol Reprod, 2019 Aug 1. PMID 31201419, Free PMC Article
  2. Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development. Bulusu V, et al. Dev Cell, 2017 Feb 27. PMID 28245920, Free PMC Article
  3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables thiamine pyrophosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transketolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transketolase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transketolase-like protein 2
NP_001258503.1
NP_083203.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271574.1 → NP_001258503.1  transketolase-like protein 2

    See identical proteins and their annotated locations for NP_001258503.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon structure in the 3' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC122800, AK029871, AV271587, BY090827
    Consensus CDS
    CCDS22334.1
    UniProtKB/Swiss-Prot
    A2RSH3, Q9D4D4
    UniProtKB/TrEMBL
    A0A0R4J2A3
    Related
    ENSMUSP00000138388.2, ENSMUST00000183187.2
    Conserved Domains (4) summary
    cd07033
    Location:324 → 479
    TPP_PYR_DXS_TK_like; Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins
    PRK05899
    Location:17 → 623
    PRK05899; transketolase; Reviewed
    cd02012
    Location:22 → 270
    TPP_TK; Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the ...
    pfam02780
    Location:495 → 617
    Transketolase_C; Transketolase, C-terminal domain

  2. NM_028927.3 → NP_083203.2  transketolase-like protein 2

    See identical proteins and their annotated locations for NP_083203.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK016603, BB019593, BY090827
    Consensus CDS
    CCDS22334.1
    UniProtKB/Swiss-Prot
    A2RSH3, Q9D4D4
    UniProtKB/TrEMBL
    A0A0R4J2A3
    Related
    ENSMUSP00000002025.4, ENSMUST00000002025.5
    Conserved Domains (4) summary
    cd07033
    Location:324 → 479
    TPP_PYR_DXS_TK_like; Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins
    PRK05899
    Location:17 → 623
    PRK05899; transketolase; Reviewed
    cd02012
    Location:22 → 270
    TPP_TK; Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the ...
    pfam02780
    Location:495 → 617
    Transketolase_C; Transketolase, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    66964392..66971851
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D4D4.1 GenPept UniProtKB/Swiss-Prot:Q9D4D4

Gene LinkOut

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