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Ranbp10 RAN binding protein 10 [ Mus musculus (house mouse) ]

Gene ID: 74334, updated on 27-Nov-2024

Summary

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Official Symbol
Ranbp10provided by MGI
Official Full Name
RAN binding protein 10provided by MGI
Primary source
MGI:MGI:1921584
See related
Ensembl:ENSMUSG00000037415 AllianceGenome:MGI:1921584
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4432417N03Rik
Summary
Enables beta-tubulin binding activity; guanyl-nucleotide exchange factor activity; and small GTPase binding activity. Acts upstream of or within microtubule cytoskeleton organization. Located in cytoplasm and microtubule cytoskeleton. Is expressed in several structures, including adrenal gland; genitourinary system; gut; liver; and nervous system. Orthologous to human RANBP10 (RAN binding protein 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in liver E14.5 (RPKM 43.4), liver E14 (RPKM 37.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ranbp10 in Genome Data Viewer
Location:
8 D3; 8 53.04 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106494940..106560463, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105768308..105833831, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4933405L10 gene Neighboring gene STARR-positive B cell enhancer ABC_E6678 Neighboring gene enkurin domain containing 1 Neighboring gene glucose-fructose oxidoreductase domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E8850 Neighboring gene STARR-positive B cell enhancer ABC_E2272 Neighboring gene translin-associated factor X (Tsnax) interacting protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E2875 Neighboring gene centromere protein T Neighboring gene THAP domain containing 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The microtubule modulator RanBP10 plays a critical role in regulation of platelet discoid shape and degranulation. Kunert S, et al. Blood, 2009 Dec 24. PMID 19801445
  2. Altered microtubule equilibrium and impaired thrombus stability in mice lacking RanBP10. Meyer I, et al. Blood, 2012 Oct 25. PMID 22936655
  3. A novel MET-interacting protein shares high sequence similarity with RanBPM, but fails to stimulate MET-induced Ras/Erk signaling. Wang D, et al. Biochem Biophys Res Commun, 2004 Jan 9. PMID 14684163
  4. Activation of Ras/Erk pathway by a novel MET-interacting protein RanBPM. Wang D, et al. J Biol Chem, 2002 Sep 27. PMID 12147692
  5. RanBP10 is a cytoplasmic guanine nucleotide exchange factor that modulates noncentrosomal microtubules. Schulze H, et al. J Biol Chem, 2008 May 16. PMID 18347012, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RanBP10 inhibits premature microtubule polymerization of beta1-tubulin and plays a pivotal role in thrombus stabilization.
    Title: Altered microtubule equilibrium and impaired thrombus stability in mice lacking RanBP10.
  2. Data suggest that RanBP10 plays an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function.
    Title: The microtubule modulator RanBP10 plays a critical role in regulation of platelet discoid shape and degranulation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-tubulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ran-binding protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145824.5 → NP_665823.3  ran-binding protein 10

    Status: VALIDATED

    Source sequence(s)
    AC152826
    Consensus CDS
    CCDS22613.1
    UniProtKB/Swiss-Prot
    Q69ZJ1, Q6VN19, Q8C328, Q8R1E6
    UniProtKB/TrEMBL
    A0A0R4J0G4, A9UGK3
    Related
    ENSMUSP00000159340.2, ENSMUST00000239468.2
    Conserved Domains (4) summary
    smart00667
    Location:257 → 284
    LisH; Lissencephaly type-1-like homology motif
    smart00668
    Location:291 → 347
    CTLH; C-terminal to LisH motif
    smart00757
    Location:507 → 604
    CRA; CT11-RanBPM
    cd12909
    Location:77 → 219
    SPRY_RanBP9_10; SPRY domain in Ran binding proteins 9 and 10

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    106494940..106560463 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243813.1 → XP_030099673.1  ran-binding protein 10 isoform X1

    Conserved Domains (4) summary
    smart00667
    Location:150 → 177
    LisH; Lissencephaly type-1-like homology motif
    smart00757
    Location:400 → 497
    CRA; CT11-RanBPM
    cd12909
    Location:10 → 112
    SPRY_RanBP9_10; SPRY domain in Ran binding proteins 9 and 10
    pfam10607
    Location:184 → 238
    CLTH; CTLH/CRA C-terminal to LisH motif domain

  2. XM_030243815.1 → XP_030099675.1  ran-binding protein 10 isoform X3

    Conserved Domains (3) summary
    smart00667
    Location:28 → 55
    LisH; Lissencephaly type-1-like homology motif
    smart00668
    Location:62 → 118
    CTLH; C-terminal to LisH motif
    smart00757
    Location:278 → 375
    CRA; CT11-RanBPM

  3. XM_030243814.1 → XP_030099674.1  ran-binding protein 10 isoform X2

    Conserved Domains (4) summary
    smart00667
    Location:125 → 152
    LisH; Lissencephaly type-1-like homology motif
    smart00757
    Location:375 → 472
    CRA; CT11-RanBPM
    pfam10607
    Location:159 → 213
    CLTH; CTLH/CRA C-terminal to LisH motif domain
    cl02614
    Location:2 → 87
    SPRY; SPRY domain

  4. XM_006531426.1 → XP_006531489.1  ran-binding protein 10 isoform X3

    See identical proteins and their annotated locations for XP_006531489.1

    Conserved Domains (3) summary
    smart00667
    Location:28 → 55
    LisH; Lissencephaly type-1-like homology motif
    smart00668
    Location:62 → 118
    CTLH; C-terminal to LisH motif
    smart00757
    Location:278 → 375
    CRA; CT11-RanBPM

  5. XM_011248526.1 → XP_011246828.1  ran-binding protein 10 isoform X3

    See identical proteins and their annotated locations for XP_011246828.1

    Conserved Domains (3) summary
    smart00667
    Location:28 → 55
    LisH; Lissencephaly type-1-like homology motif
    smart00668
    Location:62 → 118
    CTLH; C-terminal to LisH motif
    smart00757
    Location:278 → 375
    CRA; CT11-RanBPM

  6. XM_006531428.5 → XP_006531491.1  ran-binding protein 10 isoform X4

    Conserved Domains (3) summary
    smart00668
    Location:32 → 88
    CTLH; C-terminal to LisH motif
    smart00757
    Location:248 → 345
    CRA; CT11-RanBPM
    cl26729
    Location:1 → 20
    LisH
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6VN19.2 GenPept UniProtKB/Swiss-Prot:Q6VN19

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