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Ankrd45 ankyrin repeat domain 45 [ Mus musculus (house mouse) ]

Gene ID: 73844, updated on 27-Nov-2024

Summary

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Official Symbol
Ankrd45provided by MGI
Official Full Name
ankyrin repeat domain 45provided by MGI
Primary source
MGI:MGI:1921094
See related
Ensembl:ENSMUSG00000044835 AllianceGenome:MGI:1921094
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4933409K03Rik
Summary
Predicted to be involved in cell population proliferation. Predicted to be located in cleavage furrow; cytoplasm; and midbody. Orthologous to human ANKRD45 (ankyrin repeat domain 45). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in frontal lobe adult (RPKM 11.2), CNS E18 (RPKM 7.8) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Ankrd45 in Genome Data Viewer
Location:
1 H2.1; 1 69.75 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (160970017..160998077)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (161142447..161170510)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:163000837-163001115 Neighboring gene STARR-positive B cell enhancer ABC_E11097 Neighboring gene centromere protein L Neighboring gene kelch-like 20 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:163061431-163061751 Neighboring gene STARR-seq mESC enhancer starr_02813 Neighboring gene STARR-seq mESC enhancer starr_02814 Neighboring gene STARR-seq mESC enhancer starr_02815 Neighboring gene STARR-seq mESC enhancer starr_02817 Neighboring gene testis expressed 50 Neighboring gene predicted gene, 51252 Neighboring gene solute carrier family 9, member C2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
  2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Flemming body IEA
Inferred from Electronic Annotation
more info
  
located_in cleavage furrow ISO
Inferred from Sequence Orthology
more info
  
located_in cleavage furrow ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in midbody ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
ankyrin repeat domain-containing protein 45

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368766.1 → NP_001355695.1  ankyrin repeat domain-containing protein 45 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC138640
    Consensus CDS
    CCDS87902.1
    UniProtKB/Swiss-Prot
    Q810N6
    UniProtKB/TrEMBL
    D3YVW9
    Conserved Domains (3) summary
    PTZ00009
    Location:185 → 239
    PTZ00009; heat shock 70 kDa protein; Provisional
    sd00045
    Location:76 → 106
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:62 → 139
    Ank_2; Ankyrin repeats (3 copies)

  2. NM_028664.1 → NP_082940.1  ankyrin repeat domain-containing protein 45 isoform 1

    See identical proteins and their annotated locations for NP_082940.1

    Status: VALIDATED

    Source sequence(s)
    AC138640, BC049713, BY125708
    Consensus CDS
    CCDS48414.1
    UniProtKB/TrEMBL
    G3X9E0
    Related
    ENSMUSP00000059923.9, ENSMUST00000052245.9
    Conserved Domains (3) summary
    cd00204
    Location:96 → 195
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam13637
    Location:110 → 163
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:110 → 140
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    160970017..160998077
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243188.2 → XP_030099048.1  ankyrin repeat domain-containing protein 45 isoform X3

    UniProtKB/TrEMBL
    D3YVW9
    Related
    ENSMUSP00000117977.2, ENSMUST00000125018.8
    Conserved Domains (3) summary
    PTZ00009
    Location:185 → 239
    PTZ00009; heat shock 70 kDa protein; Provisional
    sd00045
    Location:76 → 106
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:62 → 139
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_030243192.2 → XP_030099052.1  ankyrin repeat domain-containing protein 45 isoform X4

    UniProtKB/Swiss-Prot
    Q810N6
    UniProtKB/TrEMBL
    D3YVW9
    Related
    ENSMUSP00000107235.2, ENSMUST00000111608.8
    Conserved Domains (3) summary
    PTZ00009
    Location:185 → 239
    PTZ00009; heat shock 70 kDa protein; Provisional
    sd00045
    Location:76 → 106
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:62 → 139
    Ank_2; Ankyrin repeats (3 copies)

  3. XM_030243184.2 → XP_030099044.2  ankyrin repeat domain-containing protein 45 isoform X1

    Conserved Domains (3) summary
    PTZ00009
    Location:246 → 300
    PTZ00009; heat shock 70 kDa protein; Provisional
    sd00045
    Location:137 → 167
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:123 → 200
    Ank_2; Ankyrin repeats (3 copies)

  4. XM_006496995.5 → XP_006497058.3  ankyrin repeat domain-containing protein 45 isoform X2

    Conserved Domains (3) summary
    PTZ00009
    Location:197 → 251
    PTZ00009; heat shock 70 kDa protein; Provisional
    sd00045
    Location:88 → 118
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:74 → 151
    Ank_2; Ankyrin repeats (3 copies)

  5. XM_030243189.2 → XP_030099049.1  ankyrin repeat domain-containing protein 45 isoform X3

    UniProtKB/TrEMBL
    D3YVW9
    Conserved Domains (3) summary
    PTZ00009
    Location:185 → 239
    PTZ00009; heat shock 70 kDa protein; Provisional
    sd00045
    Location:76 → 106
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:62 → 139
    Ank_2; Ankyrin repeats (3 copies)

  6. XM_030243190.2 → XP_030099050.1  ankyrin repeat domain-containing protein 45 isoform X3

    UniProtKB/TrEMBL
    D3YVW9
    Conserved Domains (3) summary
    PTZ00009
    Location:185 → 239
    PTZ00009; heat shock 70 kDa protein; Provisional
    sd00045
    Location:76 → 106
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:62 → 139
    Ank_2; Ankyrin repeats (3 copies)

  7. XM_017312486.3 → XP_017167975.1  ankyrin repeat domain-containing protein 45 isoform X4

    UniProtKB/Swiss-Prot
    Q810N6
    UniProtKB/TrEMBL
    D3YVW9
    Conserved Domains (3) summary
    PTZ00009
    Location:185 → 239
    PTZ00009; heat shock 70 kDa protein; Provisional
    sd00045
    Location:76 → 106
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:62 → 139
    Ank_2; Ankyrin repeats (3 copies)

  8. XM_030243191.2 → XP_030099051.1  ankyrin repeat domain-containing protein 45 isoform X3

    UniProtKB/TrEMBL
    D3YVW9
    Conserved Domains (3) summary
    PTZ00009
    Location:185 → 239
    PTZ00009; heat shock 70 kDa protein; Provisional
    sd00045
    Location:76 → 106
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:62 → 139
    Ank_2; Ankyrin repeats (3 copies)

  9. XM_017312485.3 → XP_017167974.1  ankyrin repeat domain-containing protein 45 isoform X3

    UniProtKB/TrEMBL
    D3YVW9
    Conserved Domains (3) summary
    PTZ00009
    Location:185 → 239
    PTZ00009; heat shock 70 kDa protein; Provisional
    sd00045
    Location:76 → 106
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:62 → 139
    Ank_2; Ankyrin repeats (3 copies)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q810N6.1 GenPept UniProtKB/Swiss-Prot:Q810N6

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