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Zfp433 zinc finger protein 433 [ Mus musculus (house mouse) ]

Gene ID: 73610, updated on 27-Nov-2024

Summary

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Official Symbol
Zfp433provided by MGI
Official Full Name
zinc finger protein 433provided by MGI
Primary source
MGI:MGI:1920860
See related
Ensembl:ENSMUSG00000096795 AllianceGenome:MGI:1920860
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700123A16Rik
Summary
Predicted to enable DNA binding activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and protein-macromolecule adaptor activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to several human genes including ZNF234 (zinc finger protein 234); ZNF254 (zinc finger protein 254); and ZNF28 (zinc finger protein 28). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E14 (RPKM 1.9), CNS E11.5 (RPKM 1.8) and 24 other tissues See more
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Genomic context

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See Zfp433 in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (81540581..81562021)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (81704747..81721976)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6889 Neighboring gene STARR-seq mESC enhancer starr_27348 Neighboring gene predicted gene 10778 Neighboring gene predicted gene, 51792 Neighboring gene predicted gene 8112 Neighboring gene 60S ribosomal protein L23a pseudogene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene 3055

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  2. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables damaged DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger protein 433

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243067.1 → NP_001229996.1  zinc finger protein 433 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC167202, BC064812, CN539577
    Consensus CDS
    CCDS78872.1
    UniProtKB/TrEMBL
    A0A0J9YUD4
    Related
    ENSMUSP00000144123.2, ENSMUST00000200889.4
    Conserved Domains (5) summary
    smart00349
    Location:4 → 52
    KRAB; krueppel associated box
    COG5048
    Location:160 → 575
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:164 → 184
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 43
    KRAB; KRAB box
    pfam13465
    Location:512 → 537
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001379378.1 → NP_001366307.1  zinc finger protein 433 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC167202
    Related
    ENSMUSP00000082807.6, ENSMUST00000085664.6
    Conserved Domains (2) summary
    COG5048
    Location:128 → 543
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132 → 152
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    81540581..81562021
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156045.1 → XP_036011938.1  zinc finger protein 433 isoform X1

    Conserved Domains (4) summary
    COG5048
    Location:179 → 594
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:183 → 203
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:23 → 63
    KRAB; KRAB box
    pfam13465
    Location:139 → 164
    zf-H2C2_2; Zinc-finger double domain

  2. XM_011243587.4 → XP_011241889.1  zinc finger protein 433 isoform X1

    See identical proteins and their annotated locations for XP_011241889.1

    Conserved Domains (4) summary
    COG5048
    Location:179 → 594
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:183 → 203
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:23 → 63
    KRAB; KRAB box
    pfam13465
    Location:139 → 164
    zf-H2C2_2; Zinc-finger double domain

  3. XM_011243588.4 → XP_011241890.1  zinc finger protein 433 isoform X1

    See identical proteins and their annotated locations for XP_011241890.1

    Conserved Domains (4) summary
    COG5048
    Location:179 → 594
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:183 → 203
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:23 → 63
    KRAB; KRAB box
    pfam13465
    Location:139 → 164
    zf-H2C2_2; Zinc-finger double domain

  4. XM_017314124.3 → XP_017169613.1  zinc finger protein 433 isoform X2

    Conserved Domains (2) summary
    COG5048
    Location:128 → 543
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132 → 152
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. XM_036156046.1 → XP_036011939.1  zinc finger protein 433 isoform X2

    Conserved Domains (2) summary
    COG5048
    Location:128 → 543
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132 → 152
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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