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CG42342 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 7354466, updated on 4-Jan-2025

Summary

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Official Symbol
CG42342provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0259244
Locus tag
Dmel_CG42342
See related
AllianceGenome:FB:FBgn0259244
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11769; CG14888; CG14889; CG14890; CG42243; Dmel\CG42342
Old locus tag
Dmel_CG11769; Dmel_CG14888; Dmel_CG14889; Dmel_CG14890
Summary
Predicted to be an extracellular matrix structural constituent conferring tensile strength. Predicted to be involved in extracellular matrix organization. Predicted to be part of collagen type IX trimer. Predicted to be active in basement membrane and extracellular space. Is expressed in several structures, including adult brain cell body rind; anlage in statu nascendi; epidermis; ganglia; and head epidermis primordium. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 19. Orthologous to human COL13A1 (collagen type XIII alpha 1 chain). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG42342 in Genome Data Viewer
Location:
89B18-89B20; 3-58 cM
Exon count:
19
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16502770..16571363)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12328492..12397085)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Gustatory receptor 89a Neighboring gene Death executioner caspase related to Apopain/Yama Neighboring gene long non-coding RNA:CR46030 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Protein retention in the endoplasmic reticulum rescues Aβ toxicity in Drosophila. Catterson JH, et al. Neurobiol Aging, 2023 Dec. PMID 37837732, Free PMC Article
  2. Target genes of Dpp/BMP signaling pathway revealed by transcriptome profiling in the early D.melanogaster embryo. Dominguez C, et al. Gene, 2016 Oct 10. PMID 27397649
  3. Selective maintenance of Drosophila tandemly arranged duplicated genes during evolution. Quijano C, et al. Genome Biol, 2008. PMID 19087263, Free PMC Article
  4. Measuring passive myocardial stiffness in Drosophila melanogaster to investigate diastolic dysfunction. Kaushik G, et al. J Cell Mol Med, 2012 Aug. PMID 22225769, Free PMC Article
  5. The female-specific doublesex isoform regulates pleiotropic transcription factors to pattern genital development in Drosophila. Chatterjee SS, et al. Development, 2011 Mar. PMID 21343364

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables extracellular matrix structural constituent conferring tensile strength IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in basement membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of collagen type IX trimer IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG42342-PD
CG42342-PH
CG42342-PK
CG42342-PL
CG42342-PM
CG42342-PN
CG42342-PO
CG42342-PP
CG42342-PQ
CG42342-PR
CG42342-PS
CG42342-PT

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    16502770..16571363
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001202305.2 → NP_001189234.1  uncharacterized protein Dmel_CG42342, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189234.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4JDF5
    Conserved Domains (2) summary
    pfam01391
    Location:660 → 718
    Collagen; Collagen triple helix repeat (20 copies)
    pfam15960
    Location:130 → 210
    DUF4763; Domain of unknown function (DUF4763)

  2. NM_001144589.3 → NP_001138061.1  uncharacterized protein Dmel_CG42342, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138061.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B7Z0K6, B7Z0K7, B7Z0K8, B7Z0K9, Q86NZ7
    Conserved Domains (2) summary
    pfam01391
    Location:660 → 717
    Collagen; Collagen triple helix repeat (20 copies)
    pfam15960
    Location:130 → 210
    DUF4763; Domain of unknown function (DUF4763)

  3. NM_001275712.1 → NP_001262641.1  uncharacterized protein Dmel_CG42342, isoform T [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262641.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGA1
    Conserved Domains (2) summary
    pfam01391
    Location:642 → 700
    Collagen; Collagen triple helix repeat (20 copies)
    pfam15960
    Location:130 → 210
    DUF4763; Domain of unknown function (DUF4763)

  4. NM_001260214.2 → NP_001247143.1  uncharacterized protein Dmel_CG42342, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247143.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K7C8
    Conserved Domains (2) summary
    pfam01391
    Location:642 → 699
    Collagen; Collagen triple helix repeat (20 copies)
    pfam15960
    Location:130 → 210
    DUF4763; Domain of unknown function (DUF4763)

  5. NM_001202306.2 → NP_001189235.2  uncharacterized protein Dmel_CG42342, isoform P [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189235.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4JDA4
    Conserved Domains (2) summary
    pfam01391
    Location:642 → 699
    Collagen; Collagen triple helix repeat (20 copies)
    pfam15960
    Location:130 → 210
    DUF4763; Domain of unknown function (DUF4763)

  6. NM_001170160.2 → NP_001163631.2  uncharacterized protein Dmel_CG42342, isoform Q [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163631.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JIM8
    Conserved Domains (2) summary
    pfam01391
    Location:460 → 518
    Collagen; Collagen triple helix repeat (20 copies)
    pfam15960
    Location:130 → 210
    DUF4763; Domain of unknown function (DUF4763)

  7. NM_001260212.2 → NP_001247141.2  uncharacterized protein Dmel_CG42342, isoform S [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247141.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K668
    Conserved Domains (2) summary
    pfam01391
    Location:637 → 695
    Collagen; Collagen triple helix repeat (20 copies)
    pfam15960
    Location:130 → 210
    DUF4763; Domain of unknown function (DUF4763)

  8. NM_001260213.2 → NP_001247142.1  uncharacterized protein Dmel_CG42342, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247142.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K6A0
    Conserved Domains (2) summary
    pfam01391
    Location:637 → 694
    Collagen; Collagen triple helix repeat (20 copies)
    pfam15960
    Location:130 → 210
    DUF4763; Domain of unknown function (DUF4763)

  9. NM_001144592.3 → NP_001138064.2  uncharacterized protein Dmel_CG42342, isoform O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138064.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B7Z0K8
    Conserved Domains (2) summary
    pfam01391
    Location:637 → 694
    Collagen; Collagen triple helix repeat (20 copies)
    pfam15960
    Location:130 → 210
    DUF4763; Domain of unknown function (DUF4763)

  10. NM_001275711.1 → NP_001262640.1  uncharacterized protein Dmel_CG42342, isoform R [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262640.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KH90
    Conserved Domains (2) summary
    pfam01391
    Location:455 → 513
    Collagen; Collagen triple helix repeat (20 copies)
    pfam15960
    Location:130 → 210
    DUF4763; Domain of unknown function (DUF4763)

  11. NM_001144591.3 → NP_001138063.2  uncharacterized protein Dmel_CG42342, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138063.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B7Z0K8
    Conserved Domains (2) summary
    pfam01391
    Location:348 → 395
    Collagen; Collagen triple helix repeat (20 copies)
    pfam15960
    Location:130 → 210
    DUF4763; Domain of unknown function (DUF4763)

  12. NM_001144590.3 → NP_001138062.2  uncharacterized protein Dmel_CG42342, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138062.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B7Z0K8
    Conserved Domains (2) summary
    pfam01391
    Location:343 → 390
    Collagen; Collagen triple helix repeat (20 copies)
    pfam15960
    Location:130 → 210
    DUF4763; Domain of unknown function (DUF4763)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4JDA4 A0A0B4JDA4
A0A0B4JDF5 A0A0B4JDF5
A0A0B4K668 A0A0B4K668
A0A0B4K6A0 A0A0B4K6A0
A0A0B4K7C8 A0A0B4K7C8
A0A0B4KGA1 A0A0B4KGA1
A0A0B4KH90 A0A0B4KH90
B7Z0K8.1 B7Z0K8
E1JIM8 E1JIM8

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