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Spmip8 sperm microtubule inner protein 8 [ Mus musculus (house mouse) ]

Gene ID: 73407, updated on 27-Nov-2024

Summary

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Official Symbol
Spmip8provided by MGI
Official Full Name
sperm microtubule inner protein 8provided by MGI
Primary source
MGI:MGI:1920657
See related
Ensembl:ENSMUSG00000090206 AllianceGenome:MGI:1920657
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tepp; 1700055M20Rik
Summary
Involved in flagellated sperm motility. Is active in axonemal A tubule inner sheath and sperm flagellum. Orthologous to human SPMIP8 (sperm microtubule inner protein 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 72.3) and whole brain E14.5 (RPKM 2.2) See more
Orthologs
human all
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Genomic context

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See Spmip8 in Genome Data Viewer
Location:
8 C5; 8 47.12 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (96038148..96053239)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (95311569..95326211)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:97769227-97769421 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:97771323-97771506 Neighboring gene cyclic nucleotide gated channel beta 1 Neighboring gene STARR-positive B cell enhancer ABC_E3796 Neighboring gene microtubule-associated protein 1 light chain 3 pseudogene copy 6 Neighboring gene STARR-positive B cell enhancer ABC_E8259 Neighboring gene zinc finger protein 319 Neighboring gene U6 snRNA biogenesis 1 Neighboring gene matrix metallopeptidase 15

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TEPP, a new gene specifically expressed in testis, prostate, and placenta and well conserved in chordates. Bera TK, et al. Biochem Biophys Res Commun, 2003 Dec 26. PMID 14652002
  2. Structures of sperm flagellar doublet microtubules expand the genetic spectrum of male infertility. Zhou L, et al. Cell, 2023 Jun 22. PMID 37295417
  3. Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice. Miyata H, et al. Proc Natl Acad Sci U S A, 2016 Jul 12. PMID 27357688, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • MGC107117

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in flagellated sperm motility IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in axonemal A tubule inner sheath IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in axonemal A tubule inner sheath IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in sperm flagellum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
sperm microtubule inner protein 8
Names
testis, prostate and placenta expressed
testis, prostate and placenta-expressed protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028532.3 → NP_082808.1  sperm microtubule inner protein 8 isoform 2

    See identical proteins and their annotated locations for NP_082808.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region and uses a downstream start codon compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC102518, AK006802, BY706785
    Consensus CDS
    CCDS22558.1
    UniProtKB/Swiss-Prot
    Q6IMH0
    Related
    ENSMUSP00000096080.3, ENSMUST00000098480.9

  2. NM_199455.2 → NP_955534.1  sperm microtubule inner protein 8 isoform 1

    See identical proteins and their annotated locations for NP_955534.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC102518, BC087870, BY706785
    Consensus CDS
    CCDS22557.1
    UniProtKB/Swiss-Prot
    Q3SXB6, Q6IMH0, Q9D9K7
    UniProtKB/TrEMBL
    D3YY82
    Related
    ENSMUSP00000125362.2, ENSMUST00000161029.9

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    96038148..96053239
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154321.1 → XP_036010214.1  sperm microtubule inner protein 8 isoform X3

    UniProtKB/Swiss-Prot
    Q3SXB6, Q6IMH0, Q9D9K7
    UniProtKB/TrEMBL
    D3YY82

  2. XM_036154322.1 → XP_036010215.1  sperm microtubule inner protein 8 isoform X3

    UniProtKB/Swiss-Prot
    Q3SXB6, Q6IMH0, Q9D9K7
    UniProtKB/TrEMBL
    D3YY82

  3. XM_036154323.1 → XP_036010216.1  sperm microtubule inner protein 8 isoform X4

  4. XM_036154317.1 → XP_036010210.1  sperm microtubule inner protein 8 isoform X1

  5. XM_036154316.1 → XP_036010209.1  sperm microtubule inner protein 8 isoform X1

  6. XM_036154319.1 → XP_036010212.1  sperm microtubule inner protein 8 isoform X1

  7. XM_036154318.1 → XP_036010211.1  sperm microtubule inner protein 8 isoform X1

  8. XM_036154320.1 → XP_036010213.1  sperm microtubule inner protein 8 isoform X2

  9. XM_006531402.3 → XP_006531465.1  sperm microtubule inner protein 8 isoform X2

    See identical proteins and their annotated locations for XP_006531465.1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6IMH0.1 GenPept UniProtKB/Swiss-Prot:Q6IMH0

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