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UBE2V2 ubiquitin conjugating enzyme E2 V2 [ Homo sapiens (human) ]

Gene ID: 7336, updated on 27-Nov-2024

Summary

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Official Symbol
UBE2V2provided by HGNC
Official Full Name
ubiquitin conjugating enzyme E2 V2provided by HGNC
Primary source
HGNC:HGNC:12495
See related
Ensembl:ENSG00000169139 MIM:603001; AllianceGenome:HGNC:12495
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MMS2; UEV2; EDPF1; UEV-2; DDVIT1; EDAF-1; EDPF-1; DDVit-1
Summary
Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene also shares homology with ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. It may be involved in the differentiation of monocytes and enterocytes. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 22.2), adrenal (RPKM 12.6) and 25 other tissues See more
Orthologs
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Genomic context

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See UBE2V2 in Genome Data Viewer
Location:
8q11.21
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (47997437..48064708)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (48374223..48441494)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (48920991..48977268)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19178 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19179 Neighboring gene minichromosome maintenance complex component 4 Neighboring gene RNA, U6 small nuclear 519, pseudogene Neighboring gene UBE2V2 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:48909281-48909780 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19180 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19181 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:48947276-48947776 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:48947777-48948277 Neighboring gene MPRA-validated peak7010 silencer Neighboring gene uncharacterized LOC107986941 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:49017963-49018613 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:49042982-49043566 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:49091401-49091902 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:49091903-49092402 Neighboring gene cell division cycle associated 8 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. UBE2V2 promotes metastasis by regulating EMT and predicts a poor prognosis in lung adenocarcinoma. Yang Z, et al. Cancer Med, 2023 Oct. PMID 37755128, Free PMC Article
  2. Molecular cloning of a 1alpha,25-dihydroxyvitamin D3-inducible transcript (DDVit 1) in human blood monocytes. Fritsche J, et al. Biochem Biophys Res Commun, 1997 Jun 18. PMID 9199207
  3. UBE2V2 (MMS2) is not required for effective immunoglobulin gene conversion or DNA damage tolerance in DT40. Simpson LJ, et al. DNA Repair (Amst), 2005 Apr 4. PMID 15725630
  4. Main chain and side chain dynamics of the ubiquitin conjugating enzyme variant human Mms2 in the free and ubiquitin-bound States. Spyracopoulos L, et al. Biochemistry, 2005 Jun 21. PMID 15952783
  5. [Roles of hMMS2 gene in reversing the oxaliplatin tolerance of human colon carcinoma cells]. Zhang L, et al. Yi Chuan, 2014 Apr. PMID 24846979

See all (91) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. UBE2V2 promotes metastasis by regulating EMT and predicts a poor prognosis in lung adenocarcinoma.
    Title: UBE2V2 promotes metastasis by regulating EMT and predicts a poor prognosis in lung adenocarcinoma.
  2. UBE2V2 Positively Correlates With PD-L1 Expression and Confers Poor Patient Survival in Lung Adenocarcinoma.
    Title: UBE2V2 Positively Correlates With PD-L1 Expression and Confers Poor Patient Survival in Lung Adenocarcinoma.
  3. Uev1A amino terminus stimulates poly-ubiquitin chain assembly and is required for NF-kappaB activation.
    Title: Uev1A amino terminus stimulates poly-ubiquitin chain assembly and is required for NF-κB activation.
  4. Ubc13-Mms2 cooperates with a family of RING E3 proteins in budding yeast membrane protein sorting.
    Title: Ubc13-Mms2 cooperates with a family of RING E3 proteins in budding yeast membrane protein sorting.
  5. Data suggest that ubiquitin-conjugating enzyme E2 variant 2 (Ube2V2) and ring finger protein 4 (RNF4) together induce an active conformation of the ubiquitin-conjugating enzyme Ubc13-ubiquitin (Ubc13~Ub) thioester.
    Title: Structural basis for the RING-catalyzed synthesis of K63-linked ubiquitin chains.
  6. Functional analysis of selected regulated proteins revealed that knockdown of HNRPD, PHB2 and UB2V2 can increase HCMV replication, while knockdown of A4 and KSRP resulted in decreased HCMV replication.
    Title: Subcellular quantitative proteomic analysis reveals host proteins involved in human cytomegalovirus infection.
  7. suppression of hMMS2 reverses L-OHP tolerance in differentiated human colorectal carcinoma cells by promoting apoptosis
    Title: [Roles of hMMS2 gene in reversing the oxaliplatin tolerance of human colon carcinoma cells].
  8. Data show RING finger (RNF) E3 ubiquitin ligase RNF8 dimerizes and binds to E2 ubiquitin-conjugating complex Ubc13/Mms2 with formation of Lys-63 ubiquitin chains, whereas the RNF168 RING domain is a monomer and does not catalyze Lys-6 ubiquitylation.
    Title: Molecular insights into the function of RING finger (RNF)-containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylation.
  9. the crystal structure of human OTUB1 in complex with human UBC13 and MMS2
    Title: Molecular basis of Lys-63-linked polyubiquitination inhibition by the interaction between human deubiquitinating enzyme OTUB1 and ubiquitin-conjugating enzyme UBC13.
  10. entire coding region and splice junctions of RNF8, UBC13 and MMS2 genes were screened for mutations in affected index cases from 123 Northern Finnish breast cancer families
    Title: Mutation screening of the RNF8, UBC13 and MMS2 genes in Northern Finnish breast cancer families.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA double-strand break processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of double-strand break repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of protein K63-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in postreplication repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K63-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein polyubiquitination TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein ubiquitination TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of DNA repair TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of UBC13-MMS2 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of UBC13-MMS2 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ubiquitin conjugating enzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquitin-conjugating enzyme E2 variant 2
Names
1 alpha,25-dihydroxyvitamin D3-inducible
DDVit 1
MMS2 homolog
enterocyte differentiation promoting factor
enterocyte differentiation-associated factor 1
enterocyte differentiation-associated factor EDAF-1
enterocyte differentiation-promoting factor 1
methyl methanesulfonate sensitive 2, S. cerevisiae, homolog of
vitamin D3-inducible protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003350.3 → NP_003341.1  ubiquitin-conjugating enzyme E2 variant 2

    See identical proteins and their annotated locations for NP_003341.1

    Status: REVIEWED

    Source sequence(s)
    AC021236
    Consensus CDS
    CCDS43738.1
    UniProtKB/Swiss-Prot
    Q15819
    UniProtKB/TrEMBL
    A0M8W4
    Related
    ENSP00000428209.1, ENST00000523111.7
    Conserved Domains (1) summary
    smart00212
    Location:14 → 145
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    47997437..48064708
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013808.3 → XP_016869297.2  ubiquitin-conjugating enzyme E2 variant 2 isoform X2

  2. XM_011517583.4 → XP_011515885.1  ubiquitin-conjugating enzyme E2 variant 2 isoform X1

    Conserved Domains (1) summary
    smart00212
    Location:42 → 173
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    48374223..48441494
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054361177.1 → XP_054217152.1  ubiquitin-conjugating enzyme E2 variant 2 isoform X2

  2. XM_054361176.1 → XP_054217151.1  ubiquitin-conjugating enzyme E2 variant 2 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15819.4 GenPept UniProtKB/Swiss-Prot:Q15819

Gene LinkOut

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