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Prrc1 proline-rich coiled-coil 1 [ Mus musculus (house mouse) ]

Gene ID: 73137, updated on 27-Nov-2024

Summary

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Official Symbol
Prrc1provided by MGI
Official Full Name
proline-rich coiled-coil 1provided by MGI
Primary source
MGI:MGI:1916106
See related
Ensembl:ENSMUSG00000024594 AllianceGenome:MGI:1916106
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1190002C06Rik; 2310058D16Rik; 3110038B19Rik; 9430085A19Rik
Summary
Predicted to enable protein kinase A regulatory subunit binding activity. Predicted to be involved in epithelial structure maintenance. Predicted to be located in Golgi apparatus. Predicted to be active in cytoplasm. Is expressed in Meckel's cartilage; chondrocranium; and olfactory epithelium. Orthologous to human PRRC1 (proline rich coiled-coil 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 24.1), limb E14.5 (RPKM 22.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Prrc1 in Genome Data Viewer
Location:
18 D3; 18 31.92 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (57487805..57526028)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (57354733..57392956)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 4, regulatory subunit 1 pseudogene Neighboring gene predicted gene, 57649 Neighboring gene predicted gene, 19500 Neighboring gene predicted gene, 34982

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Rearrangement of the Protein Phosphatase 1 Interactome During Heart Failure Progression. Chiang DY, et al. Circulation, 2018 Oct 9. PMID 29669786, Free PMC Article
  2. Protein-protein interaction panel using mouse full-length cDNAs. Suzuki H, et al. Genome Res, 2001 Oct. PMID 11591653, Free PMC Article
  3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein kinase A regulatory subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in epithelial structure maintenance IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
protein PRRC1
Names
proline-rich and coiled-coil-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028447.3 → NP_082723.2  protein PRRC1

    See identical proteins and their annotated locations for NP_082723.2

    Status: VALIDATED

    Source sequence(s)
    AC122117, AK143537, BY292301
    Consensus CDS
    CCDS37825.1
    UniProtKB/Swiss-Prot
    Q3UPH1, Q91YT1
    Related
    ENSMUSP00000025490.9, ENSMUST00000025490.10
    Conserved Domains (2) summary
    PHA03247
    Location:10 → 208
    PHA03247; large tegument protein UL36; Provisional
    cl00866
    Location:261 → 374
    NTPase_I-T; Protein of unknown function DUF84

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    57487805..57526028
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526289.2 → XP_006526352.1  protein PRRC1 isoform X1

    See identical proteins and their annotated locations for XP_006526352.1

    UniProtKB/Swiss-Prot
    Q3UPH1, Q91YT1
    Conserved Domains (2) summary
    PHA03247
    Location:10 → 208
    PHA03247; large tegument protein UL36; Provisional
    cl00866
    Location:261 → 374
    NTPase_I-T; Protein of unknown function DUF84

  2. XM_006526288.3 → XP_006526351.1  protein PRRC1 isoform X1

    See identical proteins and their annotated locations for XP_006526351.1

    UniProtKB/Swiss-Prot
    Q3UPH1, Q91YT1
    Conserved Domains (2) summary
    PHA03247
    Location:10 → 208
    PHA03247; large tegument protein UL36; Provisional
    cl00866
    Location:261 → 374
    NTPase_I-T; Protein of unknown function DUF84

  3. XM_030250618.1 → XP_030106478.1  protein PRRC1 isoform X1

    UniProtKB/Swiss-Prot
    Q3UPH1, Q91YT1
    Conserved Domains (2) summary
    PHA03247
    Location:10 → 208
    PHA03247; large tegument protein UL36; Provisional
    cl00866
    Location:261 → 374
    NTPase_I-T; Protein of unknown function DUF84

  4. XM_030250617.1 → XP_030106477.1  protein PRRC1 isoform X1

    UniProtKB/Swiss-Prot
    Q3UPH1, Q91YT1
    Conserved Domains (2) summary
    PHA03247
    Location:10 → 208
    PHA03247; large tegument protein UL36; Provisional
    cl00866
    Location:261 → 374
    NTPase_I-T; Protein of unknown function DUF84
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UPH1.1 GenPept UniProtKB/Swiss-Prot:Q3UPH1

Gene LinkOut

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