Emc7 ER membrane protein complex subunit 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Emc7provided by MGI
Official Full Name: ER membrane protein complex subunit 7provided by MGI
Primary source: MGI:MGI:1920274
See related: Ensembl:ENSMUSG00000055943 AllianceGenome:MGI:1920274
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ORF3; c11orf3; 2900064A13Rik
Summary: Predicted to enable carbohydrate binding activity. Predicted to contribute to membrane insertase activity. Predicted to be involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of EMC complex. Is expressed in central nervous system; liver; lung; retina nuclear layer; and skeletal muscle. Orthologous to human EMC7 (ER membrane protein complex subunit 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in cerebellum adult (RPKM 15.8), placenta adult (RPKM 15.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E3; 2 57.02 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (112285332..112302507)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (112455014..112472163)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI709542 (e-PCR)
- UniSTS:260633

AI451465 (e-PCR)
- UniSTS:165189

RH136583 (e-PCR)
- UniSTS:210563

NoName (e-PCR)
- UniSTS:488878

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
contributes_to membrane insertase activity	ISO Inferred from Sequence Orthology more info
contributes_to membrane insertase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in protein insertion into ER membrane by stop-transfer membrane-anchor sequence	ISO Inferred from Sequence Orthology more info
involved_in protein insertion into ER membrane by stop-transfer membrane-anchor sequence	ISS Inferred from Sequence or Structural Similarity more info
involved_in tail-anchored membrane protein insertion into ER membrane	ISO Inferred from Sequence Orthology more info
involved_in tail-anchored membrane protein insertion into ER membrane	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of EMC complex	IBA Inferred from Biological aspect of Ancestor more info
part_of EMC complex	ISO Inferred from Sequence Orthology more info
part_of EMC complex	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	NAS Non-traceable Author Statement more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: endoplasmic reticulum membrane protein complex subunit 7; ER membrane protein complex subunit 7

Names: UPF0480 protein C15orf24 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133749.2 → NP_598510.1 endoplasmic reticulum membrane protein complex subunit 7 precursor

See identical proteins and their annotated locations for NP_598510.1

Status: PROVISIONAL

Source sequence(s)

AL683897, AL731840

Consensus CDS

CCDS16555.1

UniProtKB/Swiss-Prot

Q9EP72

UniProtKB/TrEMBL

Q14C26

Related

ENSMUSP00000068610.6, ENSMUST00000069747.6

Conserved Domains (1) summary

pfam09430
Location:56 → 167

DUF2012; Protein of unknown function (DUF2012)