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CDK11A cyclin dependent kinase 11A [ Homo sapiens (human) ]

Gene ID: 728642, updated on 27-Nov-2024

Summary

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Official Symbol
CDK11Aprovided by HGNC
Official Full Name
cyclin dependent kinase 11Aprovided by HGNC
Primary source
HGNC:HGNC:1730
See related
Ensembl:ENSG00000008128 MIM:116951; AllianceGenome:HGNC:1730
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDC2L2; CDC2L3; p58GTA; PITSLRE; CDK11-p46; CDK11-p58; CDK11-p110
Summary
This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Expression
Ubiquitous expression in bone marrow (RPKM 22.4), small intestine (RPKM 18.4) and 25 other tissues See more
Orthologs
all
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Genomic context

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See CDK11A in Genome Data Viewer
Location:
1p36.33
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (1702379..1724357, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (1136811..1158725, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1633818..1655796, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 35 member E2B Neighboring gene ribosomal protein S7 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 31 Neighboring gene Sharpr-MPRA regulatory region 10763 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:1618619-1618776 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1619919-1620419 Neighboring gene Sharpr-MPRA regulatory region 15043 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 88 Neighboring gene matrix metallopeptidase 23A (pseudogene) Neighboring gene ATAC-STARR-seq lymphoblastoid active region 32 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1655889-1656728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1660738-1661238 Neighboring gene solute carrier family 35 member E2A (pseudogene) Neighboring gene ribosomal protein S7 pseudogene Neighboring gene uncharacterized LOC112268218 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 89 Neighboring gene NAD kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. CDK11(p58) is required for the maintenance of sister chromatid cohesion. Hu D, et al. J Cell Sci, 2007 Jul 15. PMID 17606997
  2. Genetic variations of the CDC2L2 gene are associated with type 2 diabetes in a Han Chinese cohort. Li Y, et al. Diabetes Metab Res Rev, 2007 Sep. PMID 17177267
  3. Death-signal-induced relocalization of cyclin-dependent kinase 11 to mitochondria. Feng Y, et al. Biochem J, 2005 Nov 15. PMID 16004605, Free PMC Article
  4. Structure and expression of the human p58clk-1 protein kinase chromosomal gene. Eipers PG, et al. Genomics, 1992 Jul. PMID 1639388
  5. The emerging roles and therapeutic potential of cyclin-dependent kinase 11 (CDK11) in human cancer. Zhou Y, et al. Oncotarget, 2016 Jun 28. PMID 27049727, Free PMC Article

See all (110) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Galactosyltransferase B4GALT1 confers chemoresistance in pancreatic ductal adenocarcinomas by upregulating N-linked glycosylation of CDK11(p110).
    Title: Galactosyltransferase B4GALT1 confers chemoresistance in pancreatic ductal adenocarcinomas by upregulating N-linked glycosylation of CDK11(p110).
  2. These results provided evidence that CDK11(p110) play a critical role in the tumorigenicity of esophageal squamous cell carcinoma cells, which suggests that CDK11(p110) may be a promising therapeutic target in esophageal squamous cell carcinoma.
    Title: CDK11(p110) plays a critical role in the tumorigenicity of esophageal squamous cell carcinoma cells and is a potential drug target.
  3. CDK11 has a role in human cancers [review]
    Title: The emerging roles and therapeutic potential of cyclin-dependent kinase 11 (CDK11) in human cancer.
  4. study identified p21 activated kinase 1 (PAK1) as a new CDK11(p58) substrate; mapped a new phosphorylation site of Ser174 on PAK1; results indicated PAK1 may serve as a downstream effector of CDK11(p58) during mitosis progression
    Title: CDK11p58 phosphorylation of PAK1 Ser174 promotes DLC2 binding and roles on cell cycle progression.
  5. These data identified a new negative regulatory protein of ERalpha and provided a new pathway by which CDK11(p58) negatively regulated cells.
    Title: Repression of estrogen receptor alpha by CDK11p58 through promoting its ubiquitin-proteasome degradation.
  6. Phosphorylation of the eukaryotic initiation factor 3f by cyclin-dependent kinase 11 during apoptosis.
    Title: Phosphorylation of the eukaryotic initiation factor 3f by cyclin-dependent kinase 11 during apoptosis.
  7. Observational study of gene-disease association. (HuGE Navigator)
    Title: Centrosome-related genes, genetic variation, and risk of breast cancer.
  8. CDC2L2 gene may contribute to the susceptibility of type 2 diabetes in the northern Han Chinese population.
    Title: Genetic variations of the CDC2L2 gene are associated with type 2 diabetes in a Han Chinese cohort.
  9. findings show that, in addition to playing a role in spindle formation and structure, CDK11(p58) is also required for sister chromatid cohesion and the completion of mitosis
    Title: CDK11(p58) is required for the maintenance of sister chromatid cohesion.
  10. mitotic CDK11(p58) isoform, but not the CDK11(p110) isoform, associates with mitotic centrosomes
    Title: The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ55257, FLJ56415, FLJ56557, MGC131975

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitotic cell cycle NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of RNA splicing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of apoptotic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell cycle NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of cell growth IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in regulation of centrosome cycle NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of mRNA processing IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of cyclin-dependent protein kinase holoenzyme complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cyclin-dependent kinase 11A
Names
PITSLRE B
PITSLRE serine/threonine-protein kinase CDC2L2
cell division cycle 2-like 2 (PITSLRE proteins)
cell division cycle 2-like protein kinase 2
cell division protein kinase 11A
galactosyltransferase-associated protein kinase p58/GTA
NP_001300825.1
NP_001300911.1
NP_076916.2
NP_277071.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029414.1 RefSeqGene

    Range
    4996..26974
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001313896.2 → NP_001300825.1  cyclin-dependent kinase 11A isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the central coding region compared to variant 1. The encoded isoform (5) is longer than isoform 1.
    Source sequence(s)
    AF067522, AL031282, BC073855
    Consensus CDS
    CCDS81253.1
    UniProtKB/Swiss-Prot
    O95227, O95228, O96012, Q12821, Q12853, Q12854, Q2TAJ0, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ88, Q9UQ89
    UniProtKB/TrEMBL
    B4E3D9
    Related
    ENSP00000367900.1, ENST00000378633.5
    Conserved Domains (2) summary
    cd07843
    Location:420 → 711
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
    PLN00009
    Location:423 → 713
    PLN00009; cyclin-dependent kinase A; Provisional

  2. NM_001313982.2 → NP_001300911.1  cyclin-dependent kinase 11A isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses two alternate splice sites in 5' coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AF067520, AL031282, BC073855
    Consensus CDS
    CCDS81254.1
    UniProtKB/TrEMBL
    B4E3D9, Q5QPR3
    Related
    ENSP00000350403.2, ENST00000357760.6
    Conserved Domains (2) summary
    cd07843
    Location:416 → 707
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
    PLN00009
    Location:419 → 709
    PLN00009; cyclin-dependent kinase A; Provisional

  3. NM_024011.4 → NP_076916.2  cyclin-dependent kinase 11A isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform (1).
    Source sequence(s)
    AF067519, AL031282, AL043340, BC073855, BC094827, DC388505
    Consensus CDS
    CCDS44042.1
    UniProtKB/TrEMBL
    B4E3D9
    Related
    ENSP00000384442.3, ENST00000404249.8
    Conserved Domains (2) summary
    cd07843
    Location:417 → 708
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
    PLN00009
    Location:420 → 710
    PLN00009; cyclin-dependent kinase A; Provisional

  4. NM_033529.4 → NP_277071.2  cyclin-dependent kinase 11A isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AF067521, AL031282, AL043340, BC073855, BC094827, DC388505
    Consensus CDS
    CCDS44043.1
    UniProtKB/TrEMBL
    B4E3D9
    Related
    ENSP00000351629.5, ENST00000358779.9
    Conserved Domains (2) summary
    cd07843
    Location:407 → 698
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
    PLN00009
    Location:410 → 700
    PLN00009; cyclin-dependent kinase A; Provisional

RNA

  1. NR_132739.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF067518, AL031282, BC073855
    Related
    ENST00000460465.5

  2. NR_132740.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses two alternate internal splice sites compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF067523, AL031282, BC073855

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    1702379..1724357 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    1136811..1158725 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_033527.1: Suppressed sequence

    Description
    NM_033527.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

  2. NM_033532.1: Suppressed sequence

    Description
    NM_033532.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

  3. NM_033534.1: Suppressed sequence

    Description
    NM_033534.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UQ88.4 GenPept UniProtKB/Swiss-Prot:Q9UQ88

Gene LinkOut

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