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TSPY8 testis specific protein Y-linked 8 [ Homo sapiens (human) ]

Gene ID: 728403, updated on 27-Nov-2024

Summary

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Official Symbol
TSPY8provided by HGNC
Official Full Name
testis specific protein Y-linked 8provided by HGNC
Primary source
HGNC:HGNC:37471
See related
Ensembl:ENSG00000229549 AllianceGenome:HGNC:37471
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in several processes, including gonadal mesoderm development; nucleosome assembly; and spermatogenesis. Predicted to be located in cytoplasm. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis (RPKM 34.5) See more
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Genomic context

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See TSPY8 in Genome Data Viewer
Location:
Yp11.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) Y NC_000024.10 (9357797..9360593)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) Y NC_060948.1 (8963923..8966719)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (9195406..9198202)

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene testis specific protein Y-linked 4 Neighboring gene family with sequence similarity 197 Y-linked member 8 Neighboring gene family with sequence similarity 197 Y-linked member 7 Neighboring gene testis specific protein Y-linked 7, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. Skaletsky H, et al. Nature, 2003 Jun 19. PMID 12815422
  2. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in gonadal mesoderm development IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleosome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
testis-specific Y-encoded protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243721.2 → NP_001230650.1  testis-specific Y-encoded protein 8

    See identical proteins and their annotated locations for NP_001230650.1

    Status: VALIDATED

    Source sequence(s)
    AC006158
    Consensus CDS
    CCDS59533.1
    UniProtKB/Swiss-Prot
    H7BXJ3, P0CW00
    UniProtKB/TrEMBL
    Q540R4
    Related
    ENSP00000287721.9, ENST00000287721.13
    Conserved Domains (1) summary
    cl08298
    Location:126 → 288
    NAP; Nucleosome assembly protein (NAP)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p14 Primary Assembly

    Range
    9357797..9360593
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005272744.5 → XP_005272801.1  testis-specific Y-encoded protein 8 isoform X1

    UniProtKB/TrEMBL
    A6NGL4, Q540R4
    Related
    ENSP00000372462.1, ENST00000383000.1
    Conserved Domains (1) summary
    cl08298
    Location:103 → 273
    NAP; Nucleosome assembly protein (NAP)

  2. XM_011544005.3 → XP_011542307.1  testis-specific Y-encoded protein 8 isoform X2

    Conserved Domains (1) summary
    cl08298
    Location:112 → 223
    NAP; Nucleosome assembly protein (NAP)

RNA

  1. XR_949064.3 RNA Sequence

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791821.1 Reference GRCh38.p14 PATCHES

    Range
    225079..227875
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054333422.1 → XP_054189397.1  testis-specific Y-encoded protein 8 isoform X1

    UniProtKB/TrEMBL
    A6NGL4

  2. XM_054333423.1 → XP_054189398.1  testis-specific Y-encoded protein 8 isoform X2

RNA

  1. XR_008485841.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060948.1 Alternate T2T-CHM13v2.0

    Range
    8963923..8966719
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054328331.1 → XP_054184306.1  testis-specific Y-encoded protein 8 isoform X1

  2. XM_054328332.1 → XP_054184307.1  testis-specific Y-encoded protein 8 isoform X2

RNA

  1. XR_008485527.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CW00.2 GenPept UniProtKB/Swiss-Prot:P0CW00

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