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Veph1 ventricular zone expressed PH domain-containing 1 [ Mus musculus (house mouse) ]

Gene ID: 72789, updated on 27-Nov-2024

Summary

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Official Symbol
Veph1provided by MGI
Official Full Name
ventricular zone expressed PH domain-containing 1provided by MGI
Primary source
MGI:MGI:1920039
See related
Ensembl:ENSMUSG00000027831 AllianceGenome:MGI:1920039
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Veph; 2810471M23Rik
Summary
Predicted to enable phosphatidylinositol-5-phosphate binding activity. Predicted to be involved in negative regulation of SMAD protein signal transduction and negative regulation of transforming growth factor beta receptor signaling pathway. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; eye; gonad; gut; and immune system. Orthologous to human VEPH1 (ventricular zone expressed PH domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in kidney adult (RPKM 2.2), CNS E11.5 (RPKM 0.8) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Veph1 in Genome Data Viewer
Location:
3 E1; 3 30.25 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (65960979..66204370, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (66053558..66296974, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_07874 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene predicted gene, 26442 Neighboring gene triosephosphate isomerase related sequence 2 Neighboring gene predicted gene, 54199 Neighboring gene pentraxin related gene Neighboring gene STARR-seq mESC enhancer starr_07875 Neighboring gene STARR-seq mESC enhancer starr_07876 Neighboring gene predicted gene, 35184 Neighboring gene predicted gene, 35236

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MiR-126-5p promotes contractile switching of aortic smooth muscle cells by targeting VEPH1 and alleviates Ang II-induced abdominal aortic aneurysm in mice. Shi X, et al. Lab Invest, 2020 Dec. PMID 32612287
  2. Human ortholog of Drosophila Melted impedes SMAD2 release from TGF-β receptor I to inhibit TGF-β signaling. Shathasivam P, et al. Proc Natl Acad Sci U S A, 2015 Jun 9. PMID 26039994, Free PMC Article
  3. Identification and characterization of Veph, a novel gene encoding a PH domain-containing protein expressed in the developing central nervous system of vertebrates. Muto E, et al. Biochimie, 2004 Aug. PMID 15388229
  4. PRDM16 regulates a temporal transcriptional program to promote progression of cortical neural progenitors. He L, et al. Development, 2021 Mar 17. PMID 33597191, Free PMC Article
  5. Molecular patterning of the embryonic cranial mesenchyme revealed by genome-wide transcriptional profiling. Dasgupta K, et al. Dev Biol, 2019 Nov 15. PMID 31351040, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MiR-126-5p promotes contractile switching of aortic smooth muscle cells by targeting VEPH1 and alleviates Ang II-induced abdominal aortic aneurysm in mice.
    Title: MiR-126-5p promotes contractile switching of aortic smooth muscle cells by targeting VEPH1 and alleviates Ang II-induced abdominal aortic aneurysm in mice.
  2. Veph was strongly expressed in the ventricular zone of the embryonic brain, and its expression level gradually decreased in later stages.
    Title: Identification and characterization of Veph, a novel gene encoding a PH domain-containing protein expressed in the developing central nervous system of vertebrates.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphatidylinositol-5-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of SMAD protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ventricular zone-expressed PH domain-containing protein 1
Names
protein melted homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145820.3 → NP_665819.2  ventricular zone-expressed PH domain-containing protein 1

    See identical proteins and their annotated locations for NP_665819.2

    Status: VALIDATED

    Source sequence(s)
    AC098705, AC121312, BC075649
    Consensus CDS
    CCDS17391.1
    UniProtKB/Swiss-Prot
    A1A535, E9QP23, Q8K4P5, Q8K4P6, Q9CYR8
    Related
    ENSMUSP00000029419.7, ENSMUST00000029419.8
    Conserved Domains (2) summary
    cd01264
    Location:716 → 824
    PH_MELT_VEPH1; Melted pleckstrin homology (PH) domain
    pfam00169
    Location:717 → 819
    PH; PH domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    65960979..66204370 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502143.5 → XP_006502206.1  ventricular zone-expressed PH domain-containing protein 1 isoform X2

    Conserved Domains (1) summary
    cd01264
    Location:680 → 788
    PH_MELT_VEPH1; Melted pleckstrin homology (PH) domain

  2. XM_006502142.5 → XP_006502205.1  ventricular zone-expressed PH domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006502205.1

    Conserved Domains (1) summary
    cd01264
    Location:750 → 858
    PH_MELT_VEPH1; Melted pleckstrin homology (PH) domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_028357.4: Suppressed sequence

    Description
    NM_028357.4: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1A535.2 GenPept UniProtKB/Swiss-Prot:A1A535

Gene LinkOut

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