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Serp2 stress-associated endoplasmic reticulum protein family member 2 [ Mus musculus (house mouse) ]

Gene ID: 72661, updated on 27-Nov-2024

Summary

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Official Symbol
Serp2provided by MGI
Official Full Name
stress-associated endoplasmic reticulum protein family member 2provided by MGI
Primary source
MGI:MGI:1919911
See related
Ensembl:ENSMUSG00000052584 AllianceGenome:MGI:1919911
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810032E02Rik
Summary
Predicted to be involved in endoplasmic reticulum unfolded protein response. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human SERP2 (stress associated endoplasmic reticulum protein family member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E18 (RPKM 32.4), cortex adult (RPKM 27.7) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See Serp2 in Genome Data Viewer
Location:
14 D3; 14 40.44 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (76770252..76794518, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (76532812..76557074, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene TSC22 domain family, member 1 Neighboring gene STARR-seq mESC enhancer starr_37176 Neighboring gene STARR-seq mESC enhancer starr_37178 Neighboring gene STARR-seq mESC enhancer starr_37179 Neighboring gene STARR-positive B cell enhancer ABC_E2428 Neighboring gene STARR-seq mESC enhancer starr_37180 Neighboring gene RIKEN cDNA 4930444M15 gene Neighboring gene STARR-seq mESC enhancer starr_37182 Neighboring gene predicted gene, 36845 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:76966575-76966812 Neighboring gene STARR-seq mESC enhancer starr_37187 Neighboring gene RIKEN cDNA 1700105F02 gene Neighboring gene FK506 binding protein 1a, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_37190 Neighboring gene STARR-seq mESC enhancer starr_37191

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
  2. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
  3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC118314

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to unfolded protein IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
stress-associated endoplasmic reticulum protein 2
Names
ribosome-associated membrane protein RAMP4-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160326.1 → NP_001153798.1  stress-associated endoplasmic reticulum protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001153798.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the protein coding transcript.
    Source sequence(s)
    BU057067, CF728547
    Consensus CDS
    CCDS49546.1
    UniProtKB/Swiss-Prot
    Q497L0, Q6TAW2
    Related
    ENSMUSP00000068508.8, ENSMUST00000064517.9
    Conserved Domains (1) summary
    pfam06624
    Location:2 → 58
    RAMP4; Ribosome associated membrane protein RAMP4

  2. NM_001360046.2 → NP_001346975.1  stress-associated endoplasmic reticulum protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC142266
    Conserved Domains (1) summary
    pfam06624
    Location:55 → 111
    RAMP4; Ribosome associated membrane protein RAMP4

  3. NM_001360047.1 → NP_001346976.1  stress-associated endoplasmic reticulum protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AV495881, BU057067, CF728547
    Conserved Domains (1) summary
    pfam06624
    Location:2 → 28
    RAMP4; Ribosome associated membrane protein RAMP4

  4. NM_001360048.2 → NP_001346977.1  stress-associated endoplasmic reticulum protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC142266
    Conserved Domains (1) summary
    pfam06624
    Location:55 → 81
    RAMP4; Ribosome associated membrane protein RAMP4

RNA

  1. NR_027699.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains alternate exons at the 5' end and an additional internal exon compared to variant 1. This results in translational start from an in-frame upstream AUG, and early translation termination, rendering this transcript a candidate for nonsense-mediated mRNA decay (NMD). The transcript is sufficiently abundant to represent as a RefSeq record.
    Source sequence(s)
    AC142266
    Related
    ENSMUST00000227076.2

  2. NR_153389.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AV495881, BU057067, CF728547

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    76770252..76794518 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248046.2 → XP_030103906.1  stress-associated endoplasmic reticulum protein 2 isoform X1

    Conserved Domains (1) summary
    pfam06624
    Location:56 → 81
    RAMP4; Ribosome associated membrane protein RAMP4
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6TAW2.2 GenPept UniProtKB/Swiss-Prot:Q6TAW2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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