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Pdzd11 PDZ domain containing 11 [ Mus musculus (house mouse) ]

Gene ID: 72621, updated on 27-Nov-2024

Summary

Official Symbol
Pdzd11provided by MGI
Official Full Name
PDZ domain containing 11provided by MGI
Primary source
MGI:MGI:1919871
See related
Ensembl:ENSMUSG00000015668 AllianceGenome:MGI:1919871
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pdzk11; 1810012H22Rik; 2310079D11Rik; 2700099C19Rik
Summary
Predicted to enable enzyme activator activity; protein-macromolecule adaptor activity; and transporter activator activity. Involved in pore complex assembly. Part of pore complex. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human PDZD11 (PDZ domain containing 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 23.4), placenta adult (RPKM 20.4) and 28 other tissues See more
Orthologs
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Genomic context

See Pdzd11 in Genome Data Viewer
Location:
X C3; X 43.72 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (99665949..99673667, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (100622871..100625948, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47635 Neighboring gene pyrimidinergic receptor P2Y, G-protein coupled, 4 Neighboring gene arrestin 3, retinal Neighboring gene kinesin family member 4 Neighboring gene predicted gene, 52438 Neighboring gene STARR-seq mESC enhancer starr_47636 Neighboring gene glycerophosphodiester phosphodiesterase domain containing 2 Neighboring gene predicted gene 14866

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme activator activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein-macromolecule adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transporter activator activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
involved_in biotin metabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in neurotransmitter secretion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in pore complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in pore complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pore complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synaptic assembly at neuromuscular junction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in synaptic vesicle transport IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in adherens junction IEA
Inferred from Electronic Annotation
more info
 
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of pore complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of pore complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
PDZ domain-containing protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356384.1NP_001343313.1  PDZ domain-containing protein 11

    Status: VALIDATED

    Source sequence(s)
    AK007454, BP772832, BX276129, CB316786
    Consensus CDS
    CCDS30304.1
    UniProtKB/Swiss-Prot
    Q9CZG9
    Related
    ENSMUSP00000015812.6, ENSMUST00000015812.12
    Conserved Domains (1) summary
    cd00992
    Location:45125
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  2. NM_028303.4NP_082579.1  PDZ domain-containing protein 11

    See identical proteins and their annotated locations for NP_082579.1

    Status: VALIDATED

    Source sequence(s)
    AK012624, BP772832, BX276129
    Consensus CDS
    CCDS30304.1
    UniProtKB/Swiss-Prot
    Q9CZG9
    Related
    ENSMUSP00000051068.7, ENSMUST00000059099.7
    Conserved Domains (1) summary
    cd00992
    Location:45125
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    99665949..99673667 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162102.1XP_036017995.1  PDZ domain-containing protein 11 isoform X1

    UniProtKB/Swiss-Prot
    Q9CZG9
    Conserved Domains (1) summary
    cd00992
    Location:45125
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  2. XM_011247685.2XP_011245987.1  PDZ domain-containing protein 11 isoform X1

    See identical proteins and their annotated locations for XP_011245987.1

    UniProtKB/Swiss-Prot
    Q9CZG9
    Conserved Domains (1) summary
    cd00992
    Location:45125
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...