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TRPC5 transient receptor potential cation channel subfamily C member 5 [ Homo sapiens (human) ]

Gene ID: 7224, updated on 27-Nov-2024

Summary

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Official Symbol
TRPC5provided by HGNC
Official Full Name
transient receptor potential cation channel subfamily C member 5provided by HGNC
Primary source
HGNC:HGNC:12337
See related
Ensembl:ENSG00000072315 MIM:300334; AllianceGenome:HGNC:12337
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRP5; PPP1R159
Summary
This gene belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor potential channel) proteins. The encoded protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1). [provided by RefSeq, May 2010]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

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See TRPC5 in Genome Data Viewer
Location:
Xq23
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (111768011..112082776, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (110216352..110531119, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (111011239..111326004, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:110924066-110924785 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29860 Neighboring gene RNA, 5S ribosomal pseudogene 512 Neighboring gene ALG13 UDP-N-acetylglucosaminyltransferase subunit Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20944 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:111155775-111156274 Neighboring gene TRPC5 opposite strand Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29861 Neighboring gene retrotransposon Gag like 4 Neighboring gene divergent-paired related homeobox pseudogene 7 Neighboring gene CCDC121 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Inhibition of TRPC5 channels by intracellular ATP. Dattilo M, et al. Mol Pharmacol, 2008 Jan. PMID 17925457
  2. Transient receptor potential channel TRPC5 is essential for P-glycoprotein induction in drug-resistant cancer cells. Ma X, et al. Proc Natl Acad Sci U S A, 2012 Oct 2. PMID 22988121, Free PMC Article
  3. Gs cascade regulates canonical transient receptor potential 5 (TRPC5) through cAMP mediated intracellular Ca2+ release and ion channel trafficking. Hong C, et al. Biochem Biophys Res Commun, 2012 Apr 27. PMID 22490661
  4. G protein-coupled receptor signalling potentiates the osmo-mechanical activation of TRPC5 channels. Jemal I, et al. Pflugers Arch, 2014 Aug. PMID 24177920
  5. Essential role for TrpC5-containing extracellular vesicles in breast cancer with chemotherapeutic resistance. Ma X, et al. Proc Natl Acad Sci U S A, 2014 Apr 29. PMID 24733904, Free PMC Article

See all (85) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dynamic remodeling of TRPC5 channel-caveolin-1-eNOS protein assembly potentiates the positive feedback interaction between Ca[2+] and NO signals.
    Title: Dynamic remodeling of TRPC5 channel-caveolin-1-eNOS protein assembly potentiates the positive feedback interaction between Ca(2+) and NO signals.
  2. Thermosensing ability of TRPC5: current knowledge and unsettled questions.
    Title: Thermosensing ability of TRPC5: current knowledge and unsettled questions.
  3. MiR-138-5p Inhibits Thyroid Cancer Cell Growth and Stemness by Targeting TRPC5/Wnt/beta-Catenin Pathway.
    Title: MiR-138-5p Inhibits Thyroid Cancer Cell Growth and Stemness by Targeting TRPC5/Wnt/β-Catenin Pathway.
  4. Cellular context determines primary characteristics of human TRPC5 as a cold-activated channel.
    Title: Cellular context determines primary characteristics of human TRPC5 as a cold-activated channel.
  5. Structural basis for human TRPC5 channel inhibition by two distinct inhibitors.
    Title: Structural basis for human TRPC5 channel inhibition by two distinct inhibitors.
  6. Downregulation of TRPC4 and TRPC5 Inhibits Smooth Muscle Cell Proliferation without Affecting Endothelial Cell Proliferation.
    Title: Downregulation of TRPC4 and TRPC5 Inhibits Smooth Muscle Cell Proliferation without Affecting Endothelial Cell Proliferation.
  7. Transient Receptor Potential C 1/4/5 Is a Determinant of MTI-101 Induced Calcium Influx and Cell Death in Multiple Myeloma.
    Title: Transient Receptor Potential C 1/4/5 Is a Determinant of MTI-101 Induced Calcium Influx and Cell Death in Multiple Myeloma.
  8. TRPC5 in cardiovascular diseases.
    Title: TRPC5 in cardiovascular diseases.
  9. Involvement of TRPC5 channels, inwardly rectifying K(+) channels, PLCbeta and PIP2 in vasopressin-mediated excitation of medial central amygdala neurons.
    Title: Involvement of TRPC5 channels, inwardly rectifying K(+) channels, PLCβ and PIP(2) in vasopressin-mediated excitation of medial central amygdala neurons.
  10. PIP2 regulation of TRPC5 channel activation and desensitization.
    Title: PIP(2) regulation of TRPC5 channel activation and desensitization.
Submit: New GeneRIF Correction See all GeneRIFs (61)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide and candidate gene association study of cigarette smoking behaviors.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATPase binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actinin binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables calcium channel activity TAS
Traceable Author Statement
more info
  
enables clathrin binding IEA
Inferred from Electronic Annotation
more info
  
enables inositol 1,4,5 trisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables store-operated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium ion transmembrane transport TAS
Traceable Author Statement
more info
  
involved_in calcium ion transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of dendrite morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in nervous system development TAS
Traceable Author Statement
more info
 PubMed 
involved_in neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neuron differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylserine exposure on apoptotic cell surface ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of axon extension IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of membrane hyperpolarization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of calcium channel complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cation channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in growth cone IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in presynapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
short transient receptor potential channel 5
Names
TRP-5
hTRP5
protein phosphatase 1, regulatory subunit 159
transient receptor potential channel 5
transient receptor protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021215.2 RefSeqGene

    Range
    5001..313463
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_012471.3 → NP_036603.1  short transient receptor potential channel 5

    See identical proteins and their annotated locations for NP_036603.1

    Status: REVIEWED

    Source sequence(s)
    AF054568, AL031388, AL049563
    Consensus CDS
    CCDS14561.1
    UniProtKB/Swiss-Prot
    B2RP53, O75233, Q5JXY8, Q9UL62, Q9Y514
    Related
    ENSP00000262839.2, ENST00000262839.3
    Conserved Domains (2) summary
    TIGR00870
    Location:17 → 756
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:35 → 67
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    111768011..112082776 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029774.2 → XP_016885263.1  short transient receptor potential channel 5 isoform X1

    UniProtKB/Swiss-Prot
    B2RP53, O75233, Q5JXY8, Q9UL62, Q9Y514
    Conserved Domains (2) summary
    TIGR00870
    Location:17 → 756
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:35 → 67
    ANK; ANK repeat [structural motif]

  2. XM_047442413.1 → XP_047298369.1  short transient receptor potential channel 5 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    110216352..110531119 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054327673.1 → XP_054183648.1  short transient receptor potential channel 5 isoform X1

    UniProtKB/Swiss-Prot
    B2RP53, O75233, Q5JXY8, Q9UL62, Q9Y514

  2. XM_054327674.1 → XP_054183649.1  short transient receptor potential channel 5 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UL62.1 GenPept UniProtKB/Swiss-Prot:Q9UL62

Gene LinkOut

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