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Ppp1r14d protein phosphatase 1, regulatory inhibitor subunit 14D [ Mus musculus (house mouse) ]

Gene ID: 72112, updated on 4-Jan-2025

Summary

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Official Symbol
Ppp1r14dprovided by MGI
Official Full Name
protein phosphatase 1, regulatory inhibitor subunit 14Dprovided by MGI
Primary source
MGI:MGI:1919362
See related
Ensembl:ENSMUSG00000027317 AllianceGenome:MGI:1919362
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GBPI-1; Ppp1r14; 2010107K19Rik
Summary
Predicted to enable protein serine/threonine phosphatase inhibitor activity. Predicted to be located in cytoplasm. Orthologous to human PPP1R14D (protein phosphatase 1 regulatory inhibitor subunit 14D). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in large intestine adult (RPKM 112.3), small intestine adult (RPKM 50.9) and 2 other tissues See more
Orthologs
human all
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Genomic context

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See Ppp1r14d in Genome Data Viewer
Location:
2 E5; 2 59.97 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (119048600..119060557, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (119218119..119230076, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C17 Neighboring gene STARR-positive B cell enhancer ABC_E5968 Neighboring gene 40S ribosomal protein S6 (Phosphoprotein NP33) Neighboring gene STARR-seq mESC enhancer starr_05476 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:119034498-119034685 Neighboring gene zinc finger, FYVE domain containing 19 Neighboring gene serine protease inhibitor, Kunitz type 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:119076669-119076852 Neighboring gene STARR-seq mESC enhancer starr_05478 Neighboring gene ras homolog family member V

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. GBPI, a novel gastrointestinal- and brain-specific PP1-inhibitory protein, is activated by PKC and inactivated by PKA. Liu QR, et al. Biochem J, 2004 Jan 1. PMID 12974676, Free PMC Article
  2. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein serine/threonine phosphatase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine phosphatase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine phosphatase inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein phosphatase 1 regulatory subunit 14D
Names
PKC-dependent PP1 inhibitory protein subunit 14
gastrointestinal and brain-specific PP1-inhibitory protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290796.1 → NP_001277725.1  protein phosphatase 1 regulatory subunit 14D isoform a

    See identical proteins and their annotated locations for NP_001277725.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK008348, AL929318, AY179331
    Consensus CDS
    CCDS71118.1
    UniProtKB/Swiss-Prot
    Q7TT52
    Related
    ENSMUSP00000106444.3, ENSMUST00000110820.3
    Conserved Domains (1) summary
    pfam05361
    Location:53 → 85
    PP1_inhibitor; PKC-activated protein phosphatase-1 inhibitor

  2. NM_028104.4 → NP_082380.1  protein phosphatase 1 regulatory subunit 14D isoform b

    See identical proteins and their annotated locations for NP_082380.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AK008348, AL929318
    Consensus CDS
    CCDS16596.1
    UniProtKB/Swiss-Prot
    A2AV57, Q7TT52, Q9D878
    Related
    ENSMUSP00000075453.6, ENSMUST00000076084.6
    Conserved Domains (1) summary
    pfam05361
    Location:53 → 140
    PP1_inhibitor; PKC-activated protein phosphatase-1 inhibitor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    119048600..119060557 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239782.3 → XP_011238084.1  protein phosphatase 1 regulatory subunit 14D isoform X1

    Conserved Domains (1) summary
    pfam05361
    Location:53 → 85
    PP1_inhibitor; PKC-activated protein phosphatase-1 inhibitor

  2. XM_011239783.3 → XP_011238085.1  protein phosphatase 1 regulatory subunit 14D isoform X2

    Conserved Domains (2) summary
    COG2936
    Location:21 → 97
    COG2936; Predicted acyl esterase [General function prediction only]
    pfam05361
    Location:53 → 85
    PP1_inhibitor; PKC-activated protein phosphatase-1 inhibitor
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TT52.2 GenPept UniProtKB/Swiss-Prot:Q7TT52

Gene LinkOut

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