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Phf10 PHD finger protein 10 [ Mus musculus (house mouse) ]

Gene ID: 72057, updated on 27-Nov-2024

Summary

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Official Symbol
Phf10provided by MGI
Official Full Name
PHD finger protein 10provided by MGI
Primary source
MGI:MGI:1919307
See related
Ensembl:ENSMUSG00000023883 AllianceGenome:MGI:1919307
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810055P05Rik
Summary
Predicted to enable chromatin binding activity; histone acetyltransferase activity; and transcription coregulator activity. Involved in nervous system development. Part of npBAF complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; retina; and tooth. Orthologous to human PHF10 (PHD finger protein 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in liver E14 (RPKM 29.8), liver E14.5 (RPKM 23.5) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Phf10 in Genome Data Viewer
Location:
17 8.95 cM; 17 A2
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (15165269..15181550, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (14944994..14961260, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_41895 Neighboring gene predicted gene, 23352 Neighboring gene WD repeat domain 27 Neighboring gene STARR-seq mESC enhancer starr_41897 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:15046536-15046719 Neighboring gene RIKEN cDNA 1600012H06 gene Neighboring gene STARR-positive B cell enhancer ABC_E9166 Neighboring gene dynein light chain Tctex-type 2A3 Neighboring gene STARR-seq mESC enhancer starr_41898 Neighboring gene ER membrane associated RNA degradation like 2 Neighboring gene predicted gene 3255

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Baf45a Mediated Chromatin Remodeling Promotes Transcriptional Activation for Osteogenesis and Odontogenesis. Busby T, et al. Front Endocrinol (Lausanne), 2021. PMID 35046892, Free PMC Article
  2. The BAF45a/PHF10 subunit of SWI/SNF-like chromatin remodeling complexes is essential for hematopoietic stem cell maintenance. Krasteva V, et al. Exp Hematol, 2017 Apr. PMID 27931852
  3. Neuronal and Muscle Differentiation of Mammalian Cells Is Accompanied by a Change in PHF10 Isoform Expression. Bayramova DO, et al. Dokl Biochem Biophys, 2024 Feb. PMID 38189889, Free PMC Article
  4. A Genome-wide CRISPR Screen Reveals a Role for the Non-canonical Nucleosome-Remodeling BAF Complex in Foxp3 Expression and Regulatory T Cell Function. Loo CS, et al. Immunity, 2020 Jul 14. PMID 32640256, Free PMC Article
  5. Role of the Pbrm1 subunit and the PBAF complex in Schwann cell development. Polanetzki V, et al. Sci Rep, 2022 Feb 16. PMID 35173232, Free PMC Article

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Neuronal and Muscle Differentiation of Mammalian Cells Is Accompanied by a Change in PHF10 Isoform Expression.
    Title: Neuronal and Muscle Differentiation of Mammalian Cells Is Accompanied by a Change in PHF10 Isoform Expression.
  2. these studies suggest that the BAF45a subunit of SWI/SNF-like chromatin remodeling complexes plays nonredundant and specialized roles within the developing hemopoietic tissue.
    Title: The BAF45a/PHF10 subunit of SWI/SNF-like chromatin remodeling complexes is essential for hematopoietic stem cell maintenance.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in nervous system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of T cell differentiation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of cell differentiation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of double-strand break repair NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of myoblast differentiation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of stem cell population maintenance NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of G0 to G1 transition NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of G1/S transition of mitotic cell cycle NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of mitotic metaphase/anaphase transition NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of nucleotide-excision repair NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of RSC-type complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of SWI/SNF complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromatin NAS
Non-traceable Author Statement
more info
 PubMed 
located_in kinetochore NAS
Non-traceable Author Statement
more info
 PubMed 
part_of npBAF complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of npBAF complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nuclear matrix NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
PHD finger protein 10
Names
BAF45a
BRG1-associated factor 45a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360983.2 → NP_001347912.1  PHD finger protein 10 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC182749

  2. NM_024250.5 → NP_077212.3  PHD finger protein 10 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC182749
    Consensus CDS
    CCDS28407.2
    UniProtKB/Swiss-Prot
    E9QLI2, Q99LV5, Q9D8M7
    UniProtKB/TrEMBL
    K4DI61
    Related
    ENSMUSP00000024657.6, ENSMUST00000024657.12
    Conserved Domains (2) summary
    cd15528
    Location:379 → 432
    PHD1_PHF10; PHD finger 1 found in PHD finger protein 10 (PHF10) and similar proteins
    cd15529
    Location:434 → 477
    PHD2_PHF10; PHD finger 2 found in PHD finger protein 10 (PHF10) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    15165269..15181550 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D8M7.4 GenPept UniProtKB/Swiss-Prot:Q9D8M7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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