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Nkiras2 NFKB inhibitor interacting Ras-like protein 2 [ Mus musculus (house mouse) ]

Gene ID: 71966, updated on 27-Nov-2024

Summary

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Official Symbol
Nkiras2provided by MGI
Official Full Name
NFKB inhibitor interacting Ras-like protein 2provided by MGI
Primary source
MGI:MGI:1919216
See related
Ensembl:ENSMUSG00000017837 AllianceGenome:MGI:1919216
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KBRAS2; 2410003M04Rik; 4930527H08Rik; D630018G21Rik
Summary
Enables GTPase activating protein binding activity. Acts upstream of or within several processes, including Ral protein signal transduction; regulation of signal transduction; and surfactant homeostasis. Predicted to be located in cytoplasm. Is expressed in cerebral cortex; dorsal root ganglion; and nose. Orthologous to human NKIRAS2 (NFKB inhibitor interacting Ras like 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 90.6), colon adult (RPKM 42.0) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Nkiras2 in Genome Data Viewer
Location:
11 D; 11 63.47 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100510007..100518436)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100619181..100627610)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5277 Neighboring gene outer dynein arm complex subunit 4 Neighboring gene STARR-positive B cell enhancer ABC_E8995 Neighboring gene STARR-positive B cell enhancer ABC_E7060 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:100443371-100443554 Neighboring gene 2',3'-cyclic nucleotide 3' phosphodiesterase Neighboring gene DnaJ heat shock protein family (Hsp40) member C7 Neighboring gene STARR-positive B cell enhancer ABC_E4000 Neighboring gene STARR-positive B cell enhancer ABC_E7061 Neighboring gene STARR-positive B cell enhancer ABC_E2369 Neighboring gene STARR-positive B cell enhancer ABC_E7062 Neighboring gene zinc finger protein 385C Neighboring gene chromosome 11 C17orf113 homolog Neighboring gene predicted gene, 38483 Neighboring gene DExH-box helicase 58

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. K15 promoter-driven enforced expression of NKIRAS exhibits tumor suppressive activity against the development of DMBA/TPA-induced skin tumors. Tago K, et al. Sci Rep, 2021 Oct 19. PMID 34667224, Free PMC Article
  2. κB-Ras and Ral GTPases regulate acinar to ductal metaplasia during pancreatic adenocarcinoma development and pancreatitis. Beel S, et al. Nat Commun, 2020 Jul 8. PMID 32641778, Free PMC Article
  3. KappaB-Ras is a nuclear-cytoplasmic small GTPase that inhibits NF-kappaB activation through the suppression of transcriptional activation of p65/RelA. Tago K, et al. J Biol Chem, 2010 Oct 1. PMID 20639196, Free PMC Article
  4. A pan-cancer analysis implicates human NKIRAS1 as a tumor-suppressor gene. Postler TS, et al. Proc Natl Acad Sci U S A, 2023 Nov 14. PMID 37931099, Free PMC Article
  5. RelA/p65 regulation of IkappaBbeta. Hertlein E, et al. Mol Cell Biol, 2005 Jun. PMID 15923614, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. K15 promoter-driven enforced expression of NKIRAS exhibits tumor suppressive activity against the development of DMBA/TPA-induced skin tumors.
    Title: K15 promoter-driven enforced expression of NKIRAS exhibits tumor suppressive activity against the development of DMBA/TPA-induced skin tumors.
  2. KappaB-Ras2 is a nuclear-cytoplasmic small GTPase that inhibits NF-kappaB activation through the suppression of transcriptional activation of p65/RelA.
    Title: KappaB-Ras is a nuclear-cytoplasmic small GTPase that inhibits NF-kappaB activation through the suppression of transcriptional activation of p65/RelA.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activating protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activating protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Ral protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within Ral protein signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within inflammatory response IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lung alveolus development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of canonical NF-kappaB signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of tumor necrosis factor-mediated signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within surfactant homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
NF-kappa-B inhibitor-interacting Ras-like protein 2
Names
I-kappa-B-interacting Ras-like protein 2
kappa B-Ras protein 2
kappaB-Ras2
NP_082300.1
XP_030102201.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028024.2 → NP_082300.1  NF-kappa-B inhibitor-interacting Ras-like protein 2

    See identical proteins and their annotated locations for NP_082300.1

    Status: PROVISIONAL

    Source sequence(s)
    AL591469
    Consensus CDS
    CCDS25429.1
    UniProtKB/Swiss-Prot
    Q8BWG0, Q9CR56
    UniProtKB/TrEMBL
    F6XZA4
    Related
    ENSMUSP00000017981.4, ENSMUST00000017981.10
    Conserved Domains (1) summary
    cl38936
    Location:6 → 168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    100510007..100518436
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246341.1 → XP_030102201.1  NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q8BWG0, Q9CR56
    UniProtKB/TrEMBL
    F6XZA4
    Related
    ENSMUSP00000059559.4, ENSMUST00000051947.10
    Conserved Domains (1) summary
    cl38936
    Location:6 → 168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CR56.1 GenPept UniProtKB/Swiss-Prot:Q9CR56

Gene LinkOut

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