U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ces2f carboxylesterase 2F [ Mus musculus (house mouse) ]

Gene ID: 71903, updated on 13-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Ces2fprovided by MGI
Official Full Name
carboxylesterase 2Fprovided by MGI
Primary source
MGI:MGI:1919153
See related
Ensembl:ENSMUSG00000062826 AllianceGenome:MGI:1919153
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A430088E12; 2310038E17Rik
Summary
Predicted to enable carboxylesterase activity and retinyl-palmitate esterase activity. Predicted to be involved in prostaglandin metabolic process. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to human CES2 (carboxylesterase 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Low expression observed in reference dataset See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Ces2f in Genome Data Viewer
Location:
8 D3; 8 53.04 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (105673987..105688264)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (104947355..104961130)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33141 Neighboring gene carboxylesterase 2 pseudogene Neighboring gene carboxylesterase 2E Neighboring gene carboxylesterase 2G Neighboring gene STARR-seq mESC enhancer starr_22518 Neighboring gene carboxylesterase 2E pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. Holmes RS, et al. Mamm Genome, 2010 Oct. PMID 20931200, Free PMC Article
  2. Novel gene function revealed by mouse mutagenesis screens for models of age-related disease. Potter PK, et al. Nat Commun, 2016 Aug 18. PMID 27534441, Free PMC Article
  3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (2) 
  • Targeted (2) 

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxylesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables carboxylic ester hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables retinyl-palmitate esterase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in prostaglandin metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
carboxylesterase 2F

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079865.2 → NP_001073334.2  carboxylesterase 2F isoform 1 precursor

    See identical proteins and their annotated locations for NP_001073334.2

    Status: VALIDATED

    Source sequence(s)
    BC117742
    Consensus CDS
    CCDS40453.1
    UniProtKB/TrEMBL
    Q08ED5
    Related
    ENSMUSP00000075722.6, ENSMUST00000076384.6
    Conserved Domains (1) summary
    pfam00135
    Location:32 → 540
    COesterase; Carboxylesterase family

  2. NM_001357269.1 → NP_001344198.1  carboxylesterase 2F isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    BC117743
    Consensus CDS
    CCDS90446.1
    UniProtKB/TrEMBL
    Q149K3
    Related
    ENSMUSP00000148840.2, ENSMUST00000212926.2
    Conserved Domains (1) summary
    cl21494
    Location:32 → 409
    Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    105673987..105688264
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154298.1 → XP_036010191.1  carboxylesterase 2F isoform X1

    UniProtKB/TrEMBL
    Q08ED5
    Conserved Domains (1) summary
    pfam00135
    Location:32 → 540
    COesterase; Carboxylesterase family

  2. XM_006531382.2 → XP_006531445.1  carboxylesterase 2F isoform X1

    See identical proteins and their annotated locations for XP_006531445.1

    UniProtKB/TrEMBL
    Q08ED5
    Related
    ENSMUSP00000148278.2, ENSMUST00000212820.2
    Conserved Domains (1) summary
    pfam00135
    Location:32 → 540
    COesterase; Carboxylesterase family

  3. XM_006531384.1 → XP_006531447.1  carboxylesterase 2F isoform X2

    Conserved Domains (1) summary
    pfam00135
    Location:34 → 430
    COesterase; Carboxylesterase family
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools