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ARHGEF11 Rho guanine nucleotide exchange factor 11 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 718727, updated on 17-Aug-2024

Summary

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Official Symbol
ARHGEF11provided by VGNC
Official Full Name
Rho guanine nucleotide exchange factor 11provided by VGNC
Primary source
VGNC:VGNC:69829
See related
Ensembl:ENSMMUG00000012436
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See ARHGEF11 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
44
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 1 NC_041754.1 (93919826..94030441)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 1 NC_027893.1 (131578718..131687875, complement)

Chromosome 1 - NC_041754.1Genomic Context describing neighboring genes Neighboring gene ETS variant transcription factor 3 Neighboring gene ETS variant transcription factor 3 like Neighboring gene microRNA mir-765 Neighboring gene leucine rich repeat containing 71 Neighboring gene platelet endothelial aggregation receptor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables G protein-coupled receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 11
Names
Rho guanine nucleotide exchange factor (GEF) 11

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041754.1 Reference Mmul_10 Primary Assembly

    Range
    93919826..94030441
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_028827374.1 → XP_028683207.1  rho guanine nucleotide exchange factor 11 isoform X1

    UniProtKB/TrEMBL
    A0A8J8XRX4, G7ME17, H9G2I5
    Conserved Domains (5) summary
    cd08753
    Location:346 → 490
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    PHA03307
    Location:1256 → 1579
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00160
    Location:792 → 978
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00992
    Location:62 → 136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:996 → 1138
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

  2. XM_001116843.4 → XP_001116843.1  rho guanine nucleotide exchange factor 11 isoform X7

    UniProtKB/TrEMBL
    A0A1D5QFZ2, A0A8J8XRX4, G7ME17, H9G2I5
    Related
    ENSMMUP00000046962.2, ENSMMUT00000069935.2
    Conserved Domains (6) summary
    cd08753
    Location:330 → 474
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    COG0265
    Location:61 → 120
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00992
    Location:46 → 120
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:979 → 1121
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00169
    Location:1039 → 1119
    PH; PH domain
    pfam00621
    Location:778 → 962
    RhoGEF; RhoGEF domain

  3. XM_001116835.4 → XP_001116835.1  rho guanine nucleotide exchange factor 11 isoform X12

    UniProtKB/TrEMBL
    H9G2I3
    Related
    ENSMMUP00000016333.4, ENSMMUT00000017440.4
    Conserved Domains (6) summary
    cd08753
    Location:290 → 434
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    COG0265
    Location:61 → 120
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00992
    Location:46 → 120
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:939 → 1081
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00169
    Location:999 → 1079
    PH; PH domain
    pfam00621
    Location:738 → 922
    RhoGEF; RhoGEF domain

  4. XM_015112394.2 → XP_014967880.1  rho guanine nucleotide exchange factor 11 isoform X1

    UniProtKB/TrEMBL
    A0A8J8XRX4, G7ME17, H9G2I5
    Conserved Domains (5) summary
    cd08753
    Location:346 → 490
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    PHA03307
    Location:1256 → 1579
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00160
    Location:792 → 978
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00992
    Location:62 → 136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:996 → 1138
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

  5. XM_015112387.2 → XP_014967873.1  rho guanine nucleotide exchange factor 11 isoform X1

    UniProtKB/TrEMBL
    A0A8J8XRX4, G7ME17, H9G2I5
    Conserved Domains (5) summary
    cd08753
    Location:346 → 490
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    PHA03307
    Location:1256 → 1579
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00160
    Location:792 → 978
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00992
    Location:62 → 136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:996 → 1138
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

  6. XM_028827395.1 → XP_028683228.1  rho guanine nucleotide exchange factor 11 isoform X8

    UniProtKB/TrEMBL
    A0A8J8XRX4, G7ME17, H9G2I5
    Conserved Domains (5) summary
    cd08753
    Location:346 → 490
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    PHA03307
    Location:1256 → 1547
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00160
    Location:792 → 978
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00992
    Location:62 → 136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:996 → 1138
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

  7. XM_015112439.2 → XP_014967925.1  rho guanine nucleotide exchange factor 11 isoform X10

    UniProtKB/TrEMBL
    A0A8J8XRX4, G7ME17, H9G2I5
    Conserved Domains (6) summary
    cd08753
    Location:346 → 490
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    COG0265
    Location:77 → 136
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00992
    Location:62 → 136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:996 → 1138
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00169
    Location:1056 → 1136
    PH; PH domain
    pfam00621
    Location:795 → 979
    RhoGEF; RhoGEF domain

  8. XM_015112411.2 → XP_014967897.1  rho guanine nucleotide exchange factor 11 isoform X4

    UniProtKB/TrEMBL
    H9G2I4
    Conserved Domains (6) summary
    cd08753
    Location:346 → 490
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    COG0265
    Location:77 → 136
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00992
    Location:62 → 136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:986 → 1128
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00169
    Location:1046 → 1126
    PH; PH domain
    pfam00621
    Location:785 → 969
    RhoGEF; RhoGEF domain

  9. XM_015112403.2 → XP_014967889.1  rho guanine nucleotide exchange factor 11 isoform X2

    UniProtKB/TrEMBL
    A0A8J8XRX4, G7ME17, H9G2I5
    Conserved Domains (6) summary
    cd08753
    Location:346 → 490
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    COG0265
    Location:77 → 136
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00992
    Location:62 → 136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:995 → 1137
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00169
    Location:1055 → 1135
    PH; PH domain
    pfam00621
    Location:794 → 978
    RhoGEF; RhoGEF domain

  10. XM_015112419.2 → XP_014967905.1  rho guanine nucleotide exchange factor 11 isoform X5

    UniProtKB/TrEMBL
    H9G2I4
    Conserved Domains (6) summary
    cd08753
    Location:346 → 490
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    COG0265
    Location:77 → 136
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00992
    Location:62 → 136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:985 → 1127
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00169
    Location:1045 → 1125
    PH; PH domain
    pfam00621
    Location:784 → 968
    RhoGEF; RhoGEF domain

  11. XM_015112434.2 → XP_014967920.1  rho guanine nucleotide exchange factor 11 isoform X9

    UniProtKB/TrEMBL
    H9G2I3
    Conserved Domains (6) summary
    cd08753
    Location:306 → 450
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    COG0265
    Location:77 → 136
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00992
    Location:62 → 136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:956 → 1098
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00169
    Location:1016 → 1096
    PH; PH domain
    pfam00621
    Location:755 → 939
    RhoGEF; RhoGEF domain

  12. XM_015112446.2 → XP_014967932.1  rho guanine nucleotide exchange factor 11 isoform X11

    UniProtKB/TrEMBL
    H9G2I3
    Conserved Domains (6) summary
    cd08753
    Location:306 → 450
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    COG0265
    Location:77 → 136
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00992
    Location:62 → 136
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:955 → 1097
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00169
    Location:1015 → 1095
    PH; PH domain
    pfam00621
    Location:754 → 938
    RhoGEF; RhoGEF domain

  13. XM_015112408.2 → XP_014967894.1  rho guanine nucleotide exchange factor 11 isoform X3

    UniProtKB/TrEMBL
    A0A8J8XRX4, G7ME17, H9G2I5
    Conserved Domains (6) summary
    cd08753
    Location:341 → 485
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    COG0265
    Location:72 → 131
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00992
    Location:57 → 131
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:991 → 1133
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00169
    Location:1051 → 1131
    PH; PH domain
    pfam00621
    Location:790 → 974
    RhoGEF; RhoGEF domain

  14. XM_015112426.2 → XP_014967912.1  rho guanine nucleotide exchange factor 11 isoform X6

    UniProtKB/TrEMBL
    A0A8J8XRX4, G7ME17, H9G2I5
    Conserved Domains (6) summary
    cd08753
    Location:330 → 474
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    COG0265
    Location:61 → 120
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00992
    Location:46 → 120
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13391
    Location:980 → 1122
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00169
    Location:1040 → 1120
    PH; PH domain
    pfam00621
    Location:779 → 963
    RhoGEF; RhoGEF domain

  15. XM_015112457.2 → XP_014967943.1  rho guanine nucleotide exchange factor 11 isoform X13

    UniProtKB/TrEMBL
    F7FKU2
    Conserved Domains (4) summary
    cd08753
    Location:278 → 422
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    PHA03307
    Location:1188 → 1511
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00160
    Location:724 → 910
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13391
    Location:928 → 1070
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

  16. XM_015112464.2 → XP_014967950.1  rho guanine nucleotide exchange factor 11 isoform X14

    UniProtKB/TrEMBL
    F7FKT2
    Conserved Domains (4) summary
    cd08753
    Location:238 → 382
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    cd13391
    Location:888 → 1030
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    pfam00169
    Location:948 → 1028
    PH; PH domain
    pfam00621
    Location:687 → 871
    RhoGEF; RhoGEF domain

  17. XM_028827418.1 → XP_028683251.1  rho guanine nucleotide exchange factor 11 isoform X13

    UniProtKB/TrEMBL
    F7FKU2
    Related
    ENSMMUP00000047671.2, ENSMMUT00000069454.2
    Conserved Domains (4) summary
    cd08753
    Location:278 → 422
    RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
    PHA03307
    Location:1188 → 1511
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00160
    Location:724 → 910
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13391
    Location:928 → 1070
    PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
Nucleotide Protein
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