U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SMURF1 SMAD specific E3 ubiquitin protein ligase 1 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 718616, updated on 17-Aug-2024

Summary

Official Symbol
SMURF1provided by VGNC
Official Full Name
SMAD specific E3 ubiquitin protein ligase 1provided by VGNC
Primary source
VGNC:VGNC:77726
See related
Ensembl:ENSMMUG00000009183
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See SMURF1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
19
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 3 NC_041756.1 (41125533..41247955, complement)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 3 NC_027895.1 (124449745..124572085, complement)

Chromosome 3 - NC_041756.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene transformation/transcription domain associated protein Neighboring gene E3 ubiquitin-protein ligase RNF14 pseudogene Neighboring gene uncharacterized LOC114676870 Neighboring gene karyopherin subunit alpha 7 Neighboring gene myosin heavy chain 16

Genomic regions, transcripts, and products

General gene information

Markers

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase SMURF1
NP_001244560.1
XP_014989809.1
XP_014989810.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001257631.1NP_001244560.1  E3 ubiquitin-protein ligase SMURF1

    See identical proteins and their annotated locations for NP_001244560.1

    Status: PROVISIONAL

    Source sequence(s)
    JU335584
    UniProtKB/TrEMBL
    F7HPB0, H9FXH8
    Related
    ENSMMUP00000072089.1, ENSMMUT00000106848.1
    Conserved Domains (4) summary
    cd08382
    Location:14138
    C2_Smurf-like; C2 domain present in Smad ubiquitination-related factor (Smurf)-like proteins
    smart00456
    Location:281313
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:397725
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:373725
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041756.1 Reference Mmul_10 Primary Assembly

    Range
    41125533..41247955 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015134323.2XP_014989809.1  E3 ubiquitin-protein ligase SMURF1 isoform X1

    UniProtKB/TrEMBL
    F7HPB0, H9EPZ4
    Related
    ENSMMUP00000012038.4, ENSMMUT00000012841.4
    Conserved Domains (4) summary
    cd08382
    Location:14138
    C2_Smurf-like; C2 domain present in Smad ubiquitination-related factor (Smurf)-like proteins
    smart00456
    Location:281313
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:397728
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:373728
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
  2. XM_015134324.2XP_014989810.1  E3 ubiquitin-protein ligase SMURF1 isoform X2

    UniProtKB/TrEMBL
    A0A5F7ZW63, G7MNQ4
    Related
    ENSMMUP00000068857.1, ENSMMUT00000108535.1
    Conserved Domains (4) summary
    cd08382
    Location:14138
    C2_Smurf-like; C2 domain present in Smad ubiquitination-related factor (Smurf)-like proteins
    smart00456
    Location:307339
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:423754
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:399754
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...