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Pdilt protein disulfide isomerase-like, testis expressed [ Mus musculus (house mouse) ]

Gene ID: 71830, updated on 27-Nov-2024

Summary

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Official Symbol
Pdiltprovided by MGI
Official Full Name
protein disulfide isomerase-like, testis expressedprovided by MGI
Primary source
MGI:MGI:1919080
See related
Ensembl:ENSMUSG00000030968 AllianceGenome:MGI:1919080
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700007B13Rik
Summary
Enables protein disulfide isomerase activity. Acts upstream of or within germ cell migration and spermatid development. Predicted to be active in endoplasmic reticulum. Orthologous to human PDILT (protein disulfide isomerase like, testis expressed). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis adult (RPKM 52.2) See more
Orthologs
human all
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Genomic context

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See Pdilt in Genome Data Viewer
Location:
7 F2; 7 63.9 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (119085809..119128259, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (119486586..119529036, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene glycoprotein 2 zymogen granule membrane Neighboring gene uromodulin Neighboring gene acyl-CoA synthetase medium-chain family member 5 Neighboring gene acyl-CoA synthetase medium-chain family member 2 Neighboring gene predicted gene, 39078

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A developmentally regulated chaperone complex for the endoplasmic reticulum of male haploid germ cells. van Lith M, et al. Mol Biol Cell, 2007 Aug. PMID 17507649, Free PMC Article
  2. PDILT, a divergent testis-specific protein disulfide isomerase with a non-classical SXXC motif that engages in disulfide-dependent interactions in the endoplasmic reticulum. van Lith M, et al. J Biol Chem, 2005 Jan 14. PMID 15475357
  3. Protein disulfide isomerase homolog PDILT is required for quality control of sperm membrane protein ADAM3 and male fertility [corrected]. Tokuhiro K, et al. Proc Natl Acad Sci U S A, 2012 Mar 6. PMID 22357757, Free PMC Article
  4. GPI-anchored protein complex, LY6K/TEX101, is required for sperm migration into the oviduct and male fertility in mice. Fujihara Y, et al. Biol Reprod, 2014 Mar. PMID 24501175
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Protein disulfide isomerase homolog PDILT is required for quality control of sperm membrane protein ADAM3 and male infertility
    Title: Protein disulfide isomerase homolog PDILT is required for quality control of sperm membrane protein ADAM3 and male fertility [corrected].
  2. The expression of PDILT, in addition to PDI in the testis, suggests that PDILT performs a specialized chaperone function in testicular cells. [PDILT]
    Title: PDILT, a divergent testis-specific protein disulfide isomerase with a non-classical SXXC motif that engages in disulfide-dependent interactions in the endoplasmic reticulum.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein disulfide isomerase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein folding chaperone ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within germ cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sperm motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spermatid development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein disulfide-isomerase-like protein of the testis

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027943.1 → NP_082219.1  protein disulfide-isomerase-like protein of the testis precursor

    See identical proteins and their annotated locations for NP_082219.1

    Status: VALIDATED

    Source sequence(s)
    AK005692
    Consensus CDS
    CCDS52378.1
    UniProtKB/Swiss-Prot
    Q9DAN1
    Related
    ENSMUSP00000033267.3, ENSMUST00000033267.4
    Conserved Domains (1) summary
    TIGR01130
    Location:44 → 498
    ER_PDI_fam; protein disulfide isomerase, eukaryotic

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    119085809..119128259 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242994.1 → XP_030098854.1  protein disulfide-isomerase-like protein of the testis isoform X1

    UniProtKB/Swiss-Prot
    Q9DAN1
    Conserved Domains (1) summary
    TIGR01130
    Location:44 → 498
    ER_PDI_fam; protein disulfide isomerase, eukaryotic

  2. XM_030242995.1 → XP_030098855.1  protein disulfide-isomerase-like protein of the testis isoform X1

    UniProtKB/Swiss-Prot
    Q9DAN1
    Conserved Domains (1) summary
    TIGR01130
    Location:44 → 498
    ER_PDI_fam; protein disulfide isomerase, eukaryotic

  3. XM_006508214.3 → XP_006508277.1  protein disulfide-isomerase-like protein of the testis isoform X1

    See identical proteins and their annotated locations for XP_006508277.1

    UniProtKB/Swiss-Prot
    Q9DAN1
    Conserved Domains (1) summary
    TIGR01130
    Location:44 → 498
    ER_PDI_fam; protein disulfide isomerase, eukaryotic

RNA

  1. XR_001777999.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DAN1.2 GenPept UniProtKB/Swiss-Prot:Q9DAN1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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