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Anxa9 annexin A9 [ Mus musculus (house mouse) ]

Gene ID: 71790, updated on 27-Nov-2024

Summary

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Official Symbol
Anxa9provided by MGI
Official Full Name
annexin A9provided by MGI
Primary source
MGI:MGI:1923711
See related
Ensembl:ENSMUSG00000015702 AllianceGenome:MGI:1923711
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110003P15Rik; 2310069F17Rik
Summary
Predicted to enable acetylcholine receptor activity; calcium-dependent phospholipid binding activity; and phosphatidylserine binding activity. Predicted to be involved in cell-cell adhesion. Located in collagen-containing extracellular matrix. Is expressed in several structures, including ganglia; trigeminal nerve; urinary system; vertebral axis musculature; and vibrissa. Orthologous to human ANXA9 (annexin A9). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in genital fat pad adult (RPKM 7.5), stomach adult (RPKM 4.5) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Anxa9 in Genome Data Viewer
Location:
3 F2.1; 3 40.74 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95203404..95222491, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95296093..95315180, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene 128 Neighboring gene BCL2/adenovirus E1B 19kD interacting protein like Neighboring gene prune exopolyphosphatase Neighboring gene STARR-positive B cell enhancer ABC_E2672 Neighboring gene MINDY lysine 48 deubiquitinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E9560 Neighboring gene predicted gene, 53243 Neighboring gene ceramide synthase 2 Neighboring gene SET domain, bifurcated 1 Neighboring gene STARR-seq mESC enhancer starr_08380 Neighboring gene STARR-positive B cell enhancer mm9_chr3:95161130-95161430 Neighboring gene predicted gene, 37500 Neighboring gene cortexin domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Structural and functional characterisation of the mouse annexin A9 promoter. Chlystun M, et al. Biochim Biophys Acta, 2004 Dec 6. PMID 15590064
  2. Annexin A9 is a periplakin interacting partner in membrane-targeted cytoskeletal linker protein complexes. Boczonadi V, et al. FEBS Lett, 2012 Sep 21. PMID 22841549
  3. The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Naba A, et al. Mol Cell Proteomics, 2012 Apr. PMID 22159717, Free PMC Article
  4. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
  5. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetylcholine receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables acetylcholine receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipid binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylserine binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylserine binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phospholipid binding ISO
Inferred from Sequence Orthology
more info
  
enables phospholipid binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in cell-cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in synaptic transmission, cholinergic IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in collagen-containing extracellular matrix HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
annexin A9
Names
annexin XXXI
annexin-31
annexin-9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085383.1 → NP_001078852.1  annexin A9 isoform a

    See identical proteins and their annotated locations for NP_001078852.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1), as well as variants 2 and 3, encodes the longer isoform (a).
    Source sequence(s)
    BC062140, BY781208
    Consensus CDS
    CCDS50989.1
    UniProtKB/Swiss-Prot
    Q9CQS1, Q9JHQ0
    Related
    ENSMUSP00000102801.2, ENSMUST00000107183.8
    Conserved Domains (2) summary
    pfam00191
    Location:46 → 110
    Annexin
    cl02574
    Location:222 → 264
    Annexin

  2. NM_001379545.1 → NP_001366474.1  annexin A9 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (a). Variants 1-3 all encode the same isoform (a).
    Source sequence(s)
    AC140190
    UniProtKB/Swiss-Prot
    Q9CQS1, Q9JHQ0
    Conserved Domains (2) summary
    pfam00191
    Location:46 → 110
    Annexin
    cl02574
    Location:222 → 264
    Annexin

  3. NM_001379546.1 → NP_001366475.1  annexin A9 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC140190
    Conserved Domains (2) summary
    pfam00191
    Location:236 → 301
    Annexin
    cl02574
    Location:184 → 226
    Annexin

  4. NM_023628.3 → NP_076117.2  annexin A9 isoform a

    See identical proteins and their annotated locations for NP_076117.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), as well as variants 1 and 3, encodes the longer isoform (a).
    Source sequence(s)
    AC140190
    Consensus CDS
    CCDS50989.1
    UniProtKB/Swiss-Prot
    Q9CQS1, Q9JHQ0
    Related
    ENSMUSP00000015846.3, ENSMUST00000015846.9
    Conserved Domains (2) summary
    pfam00191
    Location:46 → 110
    Annexin
    cl02574
    Location:222 → 264
    Annexin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    95203404..95222491 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163335.1 → XP_036019228.1  annexin A9 isoform X1

    Conserved Domains (2) summary
    pfam00191
    Location:236 → 301
    Annexin
    cl02574
    Location:184 → 226
    Annexin

RNA

  1. XR_375584.4 RNA Sequence

  2. XR_004941397.1 RNA Sequence

  3. XR_004941398.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JHQ0.2 GenPept UniProtKB/Swiss-Prot:Q9JHQ0

Gene LinkOut

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