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Etnppl ethanolamine phosphate phospholyase [ Mus musculus (house mouse) ]

Gene ID: 71760, updated on 27-Nov-2024

Summary

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Official Symbol
Etnpplprovided by MGI
Official Full Name
ethanolamine phosphate phospholyaseprovided by MGI
Primary source
MGI:MGI:1919010
See related
Ensembl:ENSMUSG00000019232 AllianceGenome:MGI:1919010
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Agxt2l1; 1300019H02Rik
Summary
Predicted to enable ethanolamine-phosphate phospho-lyase activity. Acts upstream of or within several processes, including cellular response to glucocorticoid stimulus; ceramide phosphoethanolamine catabolic process; and phospholipid transfer to membrane. Predicted to be located in mitochondrion. Orthologous to human ETNPPL (ethanolamine-phosphate phospho-lyase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver adult (RPKM 16.0), liver E18 (RPKM 8.2) and 4 other tissues See more
Orthologs
human all
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Genomic context

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See Etnppl in Genome Data Viewer
Location:
3 G3; 3 60.47 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (130411097..130429399)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (130617448..130635750)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene makorin, ring finger protein, 1 pseudogene Neighboring gene collagen, type XXV, alpha 1 Neighboring gene STARR-seq mESC enhancer starr_08983 Neighboring gene predicted gene, 22682 Neighboring gene STARR-seq mESC enhancer starr_08984 Neighboring gene STARR-seq mESC enhancer starr_08985 Neighboring gene predicted gene, 36322 Neighboring gene predicted gene, 36373 Neighboring gene STARR-positive B cell enhancer ABC_E4590 Neighboring gene STARR-positive B cell enhancer ABC_E4591 Neighboring gene oligosaccharyltransferase complex subunit (non-catalytic)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Utilization of ethanolamine phosphate phospholyase as a unique astrocytic marker. Tsujioka H, et al. Front Cell Neurosci, 2023. PMID 36794261, Free PMC Article
  2. The role of ethanolamine phosphate phospholyase in regulation of astrocyte lipid homeostasis. White CJ, et al. J Biol Chem, 2021 Jul. PMID 34048714, Free PMC Article
  3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The role of ethanolamine phosphate phospholyase in regulation of astrocyte lipid homeostasis.
    Title: The role of ethanolamine phosphate phospholyase in regulation of astrocyte lipid homeostasis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (7)  1 citation
  • Targeted (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ethanolamine-phosphate phospho-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ethanolamine-phosphate phospho-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables ethanolamine-phosphate phospho-lyase activity ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables transaminase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within cellular response to glucocorticoid stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within ceramide phosphoethanolamine catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lipid homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phospholipid transfer to membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to food IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ethanolamine-phosphate phospho-lyase
Names
alanine--glyoxylate aminotransferase 2-like 1
NP_001157059.1
NP_082183.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163587.1 → NP_001157059.1  ethanolamine-phosphate phospho-lyase

    See identical proteins and their annotated locations for NP_001157059.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK049937, BC058592
    Consensus CDS
    CCDS38638.1
    UniProtKB/Swiss-Prot
    Q811K4, Q8BWU8, Q9DBB3
    UniProtKB/TrEMBL
    E9PYH3
    Related
    ENSMUSP00000131294.2, ENSMUST00000166187.8
    Conserved Domains (2) summary
    cd00610
    Location:26 → 433
    OAT_like; Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase, ...
    COG0160
    Location:11 → 437
    GabT; 4-aminobutyrate aminotransferase or related aminotransferase [Amino acid transport and metabolism]

  2. NM_027907.3 → NP_082183.2  ethanolamine-phosphate phospho-lyase

    See identical proteins and their annotated locations for NP_082183.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK005060, BC058592
    Consensus CDS
    CCDS38638.1
    UniProtKB/Swiss-Prot
    Q811K4, Q8BWU8, Q9DBB3
    UniProtKB/TrEMBL
    E9PYH3
    Related
    ENSMUSP00000072121.7, ENSMUST00000072271.13
    Conserved Domains (2) summary
    cd00610
    Location:26 → 433
    OAT_like; Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase, ...
    COG0160
    Location:11 → 437
    GabT; 4-aminobutyrate aminotransferase or related aminotransferase [Amino acid transport and metabolism]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    130411097..130429399
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BWU8.1 GenPept UniProtKB/Swiss-Prot:Q8BWU8

Gene LinkOut

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