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Lrrcc1 leucine rich repeat and coiled-coil domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 71710, updated on 27-Nov-2024

Summary

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Official Symbol
Lrrcc1provided by MGI
Official Full Name
leucine rich repeat and coiled-coil domain containing 1provided by MGI
Primary source
MGI:MGI:1918960
See related
Ensembl:ENSMUSG00000027550 AllianceGenome:MGI:1918960
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1200008A14Rik; 4932441F23Rik
Summary
Predicted to be involved in cell division. Predicted to be located in centriole. Predicted to be active in centrosome and cytoplasm. Is expressed in several structures, including alimentary system; cranium; genitourinary system; heart valve; and nervous system. Orthologous to human LRRCC1 (leucine rich repeat and coiled-coil centrosomal protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis adult (RPKM 4.8), CNS E11.5 (RPKM 3.7) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Lrrcc1 in Genome Data Viewer
Location:
3 A1; 3 3.08 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (14595512..14637718)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (14533762..14572658)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 7 (cationic amino acid transporter, y+ system), member 12 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene E2F transcription factor 5 Neighboring gene STARR-positive B cell enhancer ABC_E2065 Neighboring gene STARR-seq mESC enhancer starr_07000 Neighboring gene ribosomal biogenesis factor Neighboring gene STARR-seq mESC enhancer starr_07001 Neighboring gene predicted gene, 54191

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. In vitro selection of Jun-associated proteins using mRNA display. Horisawa K, et al. Nucleic Acids Res, 2004 Dec 2. PMID 15576676, Free PMC Article
  2. The transcription factor GATA-6 regulates pathological cardiac hypertrophy. van Berlo JH, et al. Circ Res, 2010 Oct 15. PMID 20705924, Free PMC Article
  3. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  5. KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility. Gu J, et al. Cell Death Differ, 2023 Jul. PMID 37142655, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC106275

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in centriole IEA
Inferred from Electronic Annotation
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
leucine-rich repeat and coiled-coil domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163579.1 → NP_001157051.1  leucine-rich repeat and coiled-coil domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001157051.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC140350, BC138734
    Consensus CDS
    CCDS50866.1
    UniProtKB/Swiss-Prot
    B2RS58, Q4FZD6, Q69ZB0, Q6P8L1, Q9CUE1, Q9DC06
    UniProtKB/TrEMBL
    G5E8Y2
    Related
    ENSMUSP00000126560.2, ENSMUST00000169079.8
    Conserved Domains (9) summary
    COG0419
    Location:421 → 952
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG4886
    Location:30 → 115
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:43 → 61
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:158 → 188
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:61 → 101
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:82 → 142
    LRR_8; Leucine rich repeat
    pfam15665
    Location:793 → 1026
    FAM184; Family with sequence similarity 184, A and B
    cl00240
    Location:915 → 969
    RRF; Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another round of ...
    cl19219
    Location:817 → 894
    DUF342; Protein of unknown function (DUF342)

  2. NM_001163580.1 → NP_001157052.1  leucine-rich repeat and coiled-coil domain-containing protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC140350, BC138734
    Consensus CDS
    CCDS50865.1
    UniProtKB/Swiss-Prot
    B2RS58, Q4FZD6, Q69ZB0, Q6P8L1, Q9CUE1, Q9DC06
    UniProtKB/TrEMBL
    E9QNC6
    Related
    ENSMUSP00000088875.4, ENSMUST00000091325.10
    Conserved Domains (9) summary
    COG0419
    Location:405 → 936
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG4886
    Location:30 → 115
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:43 → 61
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:158 → 188
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:61 → 101
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:82 → 142
    LRR_8; Leucine rich repeat
    pfam15665
    Location:777 → 1010
    FAM184; Family with sequence similarity 184, A and B
    cl00240
    Location:899 → 953
    RRF; Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another round of ...
    cl19219
    Location:801 → 878
    DUF342; Protein of unknown function (DUF342)

  3. NM_028915.3 → NP_083191.2  leucine-rich repeat and coiled-coil domain-containing protein 1 isoform 3

    See identical proteins and their annotated locations for NP_083191.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC140350, AI646154, BC138734
    Consensus CDS
    CCDS38390.1
    UniProtKB/Swiss-Prot
    B2RS58, Q4FZD6, Q69ZB0, Q6P8L1, Q9CUE1, Q9DC06
    UniProtKB/TrEMBL
    A0A9L6HJP5
    Related
    ENSMUSP00000104007.3, ENSMUST00000108370.9
    Conserved Domains (8) summary
    COG4886
    Location:30 → 115
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:43 → 61
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:158 → 188
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:61 → 101
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:82 → 142
    LRR_8; Leucine rich repeat
    pfam15665
    Location:793 → 981
    FAM184; Family with sequence similarity 184, A and B
    cl00240
    Location:915 → 969
    RRF; Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another round of ...
    cl19219
    Location:817 → 894
    DUF342; Protein of unknown function (DUF342)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    14595512..14637718
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163334.1 → XP_036019227.1  leucine-rich repeat and coiled-coil domain-containing protein 1 isoform X4

    UniProtKB/Swiss-Prot
    B2RS58, Q4FZD6, Q69ZB0, Q6P8L1, Q9CUE1, Q9DC06
    Conserved Domains (2) summary
    COG0419
    Location:299 → 830
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd21340
    Location:2 → 75
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  2. XM_030252826.1 → XP_030108686.1  leucine-rich repeat and coiled-coil domain-containing protein 1 isoform X3

    UniProtKB/Swiss-Prot
    B2RS58, Q4FZD6, Q69ZB0, Q6P8L1, Q9CUE1, Q9DC06
    Conserved Domains (3) summary
    COG0419
    Location:340 → 871
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    sd00031
    Location:25 → 50
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:24 → 91
    LRR_8; Leucine rich repeat

  3. XM_006530089.3 → XP_006530152.1  leucine-rich repeat and coiled-coil domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RS58, Q4FZD6, Q69ZB0, Q6P8L1, Q9CUE1, Q9DC06
    Conserved Domains (3) summary
    COG0419
    Location:340 → 871
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    sd00031
    Location:25 → 50
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:24 → 91
    LRR_8; Leucine rich repeat

  4. XM_036163333.1 → XP_036019226.1  leucine-rich repeat and coiled-coil domain-containing protein 1 isoform X2

    UniProtKB/Swiss-Prot
    B2RS58, Q4FZD6, Q69ZB0, Q6P8L1, Q9CUE1, Q9DC06
    Conserved Domains (3) summary
    COG0419
    Location:324 → 855
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    sd00031
    Location:25 → 50
    LRR_1; leucine-rich repeat [structural motif]
    cd21340
    Location:25 → 116
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  5. XM_006530090.4 → XP_006530153.1  leucine-rich repeat and coiled-coil domain-containing protein 1 isoform X5

    UniProtKB/TrEMBL
    F7ANC5
    Related
    ENSMUSP00000129368.2, ENSMUST00000167858.8
    Conserved Domains (2) summary
    COG1196
    Location:400 → 653
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:65 → 637
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RNA

  1. XR_003954391.2 RNA Sequence

  2. XR_004941396.1 RNA Sequence

  3. XR_387522.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q69ZB0.2 GenPept UniProtKB/Swiss-Prot:Q69ZB0

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