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LOC716834 alpha-2-macroglobulin [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 716834, updated on 9-Nov-2023

Summary

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Gene symbol
LOC716834
Gene description
alpha-2-macroglobulin
See related
Ensembl:ENSMMUG00000003238
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Also known as
A2M
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Genomic context

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See LOC716834 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
36
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 11 NC_041764.1 (10640881..10687521)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 11 NC_027903.1 (9372682..9419285, complement)

Chromosome 11 - NC_041764.1Genomic Context describing neighboring genes Neighboring gene pregnancy zone protein Neighboring gene translationally-controlled tumor protein pseudogene Neighboring gene protein BTG1 pseudogene Neighboring gene putative uncharacterized protein encoded by LINC00612 Neighboring gene voltage-dependent anion-selective channel protein 2 pseudogene Neighboring gene heterogeneous nuclear ribonucleoprotein A1-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
alpha-2-macroglobulin

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041764.1 Reference Mmul_10 Primary Assembly

    Range
    10640881..10687521
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001114328.4 → XP_001114328.2  alpha-2-macroglobulin isoform X2

    UniProtKB/TrEMBL
    F6TNV9, H9YYI2, I0FKF5
    Related
    ENSMMUP00000019581.3, ENSMMUT00000020932.4
    Conserved Domains (6) summary
    COG2373
    Location:124 → 1071
    YfaS; Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only]
    cd02897
    Location:958 → 1264
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam01835
    Location:129 → 221
    A2M_N; MG2 domain
    pfam00207
    Location:738 → 828
    A2M; Alpha-2-macroglobulin family
    pfam07677
    Location:1376 → 1463
    A2M_recep; A-macroglobulin receptor
    pfam07703
    Location:459 → 607
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region

  2. XM_015151038.2 → XP_015006524.2  alpha-2-macroglobulin isoform X1

    UniProtKB/TrEMBL
    H9YYI2, I0FKF5
    Conserved Domains (6) summary
    COG2373
    Location:124 → 1071
    YfaS; Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only]
    cd02897
    Location:958 → 1264
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam01835
    Location:129 → 221
    A2M_N; MG2 domain
    pfam00207
    Location:738 → 828
    A2M; Alpha-2-macroglobulin family
    pfam07677
    Location:1376 → 1463
    A2M_recep; A-macroglobulin receptor
    pfam07703
    Location:459 → 607
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
Nucleotide Protein
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